Design and characterization of neurodurable gellan-xanthan pH-responsive hydrogels for controlled drug delivery

Ramburrun, Poornima; Kumar, Pradeep; Choonara, Yahya E.; Toit, Lisa C. du; Pillay, Viness

doi:10.1080/17425247.2017.1266331

Cited by 27 publications

(4 citation statements)

References 35 publications

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“…Furthermore, GG is a water-soluble anionic polysaccharide secreted by bacteria of the genus Sphingomonas ( 21 ) and has been demonstrated to form stable network structures in hydrogel solutions ( 22 ). GG has been widely used as an immobilization matrix in the food industry and for drug delivery ( 23 ). Data in the present study revealed that at very low concentrations (0.03% w/v), GG inhibited the sedimentation of tumorspheres and maintained them in suspension without additional devices.…”

Section: Discussionmentioning

confidence: 99%

A novel three‑dimensional tumorsphere culture system for the efficient and low‑cost enrichment of cancer stem cells with natural polymers

et al. 2017

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Cancer stem cells (CSCs) are considered to serve a key role in tumor progression, recurrence and metastasis. Tumorsphere culture is the most important method for enriching CSCs and is widely used in basic research and drug screening. However, the traditional suspension cell culture system has several disadvantages, including low efficiency, high cost and difficult procedure, making it difficult to produce tumorspheres on a large scale. In the present study, two biomaterials, methylcellulose (MC) and gellan gum (GG), were used to construct a novel culture system based on the traditional system. Subsequently, the characteristics of the novel three-dimensional (3D) culture system were evaluated, the design scheme was optimized, and the morphological and biological features of the tumorspheres cultured in this 3D system were compared with the traditional system. The results revealed that the tumorspheres cultured in the novel 3D system presented a higher seeding density and improved morphology, while maintaining stem-like properties. This evidence suggests that a simple, efficient and low-cost culture system that produces tumorspheres on a large scale was successfully constructed, which can be widely used in various aspects of stem cell research.

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Section: Discussionmentioning

confidence: 99%

A novel three‑dimensional tumorsphere culture system for the efficient and low‑cost enrichment of cancer stem cells with natural polymers

et al. 2017

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“…This result was obtained due to the combination of a pH-responsive (pH 7.4) dissolution of the PMMA particles and the distinct gelling and degradation properties due to the presence of xanthan gum. The variation of the gellan–xanthan ratio and the pore-inducing properties of intercalated PMMA enabled fine-tuning of the mechanical properties of the hydrogel matrices, particularly the matrix rigidity and flexibility [ 89 ].…”

Section: Gellan Gum (Gg)mentioning

confidence: 99%

Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair

et al. 2023

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Neurological disorders affecting both CNS and PNS still represent one of the most critical and challenging pathologies, therefore many researchers have been focusing on this field in recent decades. Spinal cord injury (SCI) and peripheral nerve injury (PNI) are severely disabling diseases leading to dramatic and, in most cases, irreversible sensory, motor, and autonomic impairments. The challenging pathophysiologic consequences involved in SCI and PNI are demanding the development of more effective therapeutic strategies since, as yet, a therapeutic strategy that can effectively lead to a complete recovery from such pathologies is not available. Drug delivery systems (DDSs) based on polysaccharides have been receiving more and more attention for a wide range of applications, due to their outstanding physical-chemical properties. This review aims at providing an overview of the most studied polysaccharides used for the development of DDSs intended for the repair and regeneration of a damaged nervous system, with particular attention to spinal cord and peripheral nerve injury treatments. In particular, DDSs based on chitosan and their association with alginate, dextran, agarose, cellulose, and gellan were thoroughly revised.

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“…Xanthan gum is a microbial polysaccharide produced by Xanthomonas bacteria; it is negatively charged and widely used for tissue engineering (A. Kumar, Rao, & Han, ) and drug delivery (Salamanca, Yarce, Moreno, Prieto, & Recalde, ). Xanthan gum‐chitosan nanofibers (Shekarforoush, Ajalloueian, Zeng, Mendes, & Chronakis, ), gellan‐xanthan systems (Ramburrun, Kumar, Choonara, du Toit, & Pillay, ; Sehgal, Roohani‐Esfahani, Zreiqat, & Banerjee, ), and ‐xanthan gum hydrogels perform great in biomedical applications (R. Zhang et al, ).…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Design and characterization of neurodurable gellan-xanthan pH-responsive hydrogels for controlled drug delivery

Cited by 27 publications

References 35 publications

A novel three‑dimensional tumorsphere culture system for the efficient and low‑cost enrichment of cancer stem cells with natural polymers

A novel three‑dimensional tumorsphere culture system for the efficient and low‑cost enrichment of cancer stem cells with natural polymers

Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair

Carbohydrate‐based nanomaterials for biomedical applications

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