Design and characterization of dual drug delivery based on in-situ assembled PVA/PAN core-shell nanofibers for wound dressing application

Abstract

Core-shell nanofibers with the ability to carry multiple drugs are attracting the attention to develop appropriate drug delivery systems for wounds dressing applications. In this study, biocompatible core-shell nanofibers have been designed as a promising dual-drug carrier with the capability of delivering both water-soluble and organic solvent-soluble drugs simultaneously. With the aim of fabricating the core-shell nanofibers, the dipping method has been employed. For this propose, core nanofibers made from polyvinyl alcohol (PVA) were immersed in various concentrations of polyacrylonitrile (PAN) and cross-linked by dipping into ethanol. Diclofenac sodium salt (DSs) and gentamicin sulfate (GENs) have been loaded into the core and shell nanofibers as models of the drug, respectively. The morphology study of core-shell nanofibers showed that the concentrations between 1% w/w up to 2% w/w PAN/GENs, with deep penetration into the internal layers of PAV/DSs nanofibers could lead to the core-shell structure. The cytotoxicity results showed the competency of designed core-shell nanofibers for wound dressing application. Also, the release profile exhibits the controllable behavior of drug release.

Fabrication and characterization of wound dressings containing gentamicin/silver for wounds in diabetes mellitus patients

“…XPS study was done to investigate the presence of Ag nanoparticles in the chemical structure of the CA/Ge/Ag nanofibers. It was confirmed that nanoparticles of Ag were present in form of Ag was chemically interacted at Ag3d 5/2 & Ag3d 3/2 with binding energy 366 eV and 372 eV [15], respectively as shown in figure 5(B). Similarly, Ag was interacted at S2p with binding energy 165 eV as shown in figure 5.…”

Electrospinning: A promising technique for drug delivery systems

“…For triaxial needle electrospinning, a third polymer solution can be incorporated into the system, it can be used to supply and release two different drugs with the dual delivery system [45][46][47][48], the intermediate layer can act as an isolation layer between the sheath and core materials. Furthermore, triaxial fiber can be formed with varying hydrophobicity and mechanical strength.…”

Development of Moringa oleifera Standardized Leaf Extract Nanofibers Impregnated onto Hydrocolloid Film as A Potential Chronic Wound Dressing

“…The protocol of nanofiber fabrication via electrospinning method was adapted from Krstic et al [10] with slight modification. PEO (4-6 % w/w) was dissolved in sterile deionised water and stirred homogeneously with magnetic stirrer at 80 °C for 60 mins.…”

“…Hence it is an ideal platform for wound delivery of therapeutic agents. Currently, various types of polymers were studied to produce nanofibers for wounds especially delayed chronic or burn wounds, these include polyvinyl alcohol (PVA), polyacrylonitrile (PAN), cellulose acetate, chitosan and polyethylene oxide (PEO) [8][9][10][11][12][13]. PEO is a biodegradable and non-toxic hydrophilic polymer which has been widely utilised in nanofiber fabrication process.…”