Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents

Calvo, Natalia Lorena; Sreekumar, Sruthi; Svetaz, Laura; Lamas, María Celina; Moerschbacher, Bruno M.; Leonardi, Darío

doi:10.3390/ijms20153686

Cited by 31 publications

(15 citation statements)

References 49 publications

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“…Both drug-loaded nanocapsules presented fungicidal activity at non-toxic concentration (12 µg/mL) as both showed excellent time-to-kill profile with complete eradication of C. albicans culture in three days. Therefore, these results displayed the feasibility of this system for local treatment of vaginal candidiasis [ 78 ]. Finally, it is evident to mention that the exploration of delivering therapeutics against vaginal infection could effectively be monitored and controlled using this polymeric nanoparticular platform.…”

Section: Novel Approaches For Vaginal Drug Delivery For Microbial mentioning

confidence: 96%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

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Section: Novel Approaches For Vaginal Drug Delivery For Microbial mentioning

confidence: 96%

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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“…Chaichanasak et al prepared the chitosan-based nanoparticles with damnacanthal (DAM). DAM increased the levels of the tumour suppressor non-steroidal anti-inflammatory drugs-activated gene 1 in the nucleus, therefore causing improved anticancer effects [ 118 ].…”

Section: Chitosan-based Nanoformulationsmentioning

confidence: 99%

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

et al. 2021

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The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.

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“…Chitosan and its chemical derivates have been used as building blocks for drug delivery nanoformulations in light of their biocompatibility, biodegradability, and mucoadhesivity, presenting some advantages such as in situ gelling performance, mucoadhesive properties, and ability to prolong the release of low-molecular-weight compounds to macromolecular drugs [116]. Chitosan nanoparticles have proven to exhibit great antimicrobial activity against Candida infections [1].…”

Section: Antifungal Potential Of Nanoparticlesmentioning

confidence: 99%

Current Insights on Antifungal Therapy: Novel Nanotechnology Approaches for Drug Delivery Systems and New Drugs from Natural Sources

et al. 2020

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The high incidence of fungal infections has become a worrisome public health issue, having been aggravated by an increase in host predisposition factors. Despite all the drugs available on the market to treat these diseases, their efficiency is questionable, and their side effects cannot be neglected. Bearing that in mind, it is of upmost importance to synthetize new and innovative carriers for these medicines not only to fight emerging fungal infections but also to avert the increase in drug-resistant strains. Although it has revealed to be a difficult job, new nano-based drug delivery systems and even new cellular targets and compounds with antifungal potential are now being investigated. This article will provide a summary of the state-of-the-art strategies that have been studied in order to improve antifungal therapy and reduce adverse effects of conventional drugs. The bidirectional relationship between Mycology and Nanotechnology will be also explained. Furthermore, the article will focus on new compounds from the marine environment which have a proven antifungal potential and may act as platforms to discover drug-like characteristics, highlighting the challenges of the translation of these natural compounds into the clinical pipeline.

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Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents

Cited by 31 publications

References 49 publications

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Current Insights on Antifungal Therapy: Novel Nanotechnology Approaches for Drug Delivery Systems and New Drugs from Natural Sources

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