Design and characterization of biofunctional magnetic porous silicon flakes

Noval, Álvaro Muñoz; García, R. Guadalupe; Casas, Diego Ruiz; Bayo, D. Losada; Vaquero, Vanessa Sánchez; Costa, Vicente Torres; Martín-Palma, Raúl J.; García, M. A.; Ruiz, Josefa Predestinación García; Olmedo, José Javier Serrano; Negrete, J.F. Muñoz; Guerrero, Francisco del Pozo; Manso‐Silván, Miguel

doi:10.1016/j.actbio.2012.12.008

Cited by 14 publications

(5 citation statements)

References 29 publications

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“…Although this self-reporting property has been demonstrated in vitro , prior to this study it had not been demonstrated in the living eye. However it should be noted that the in vivo sensing aspects of porous Si have been demonstrated in live animal eyes in the form of ocular pressure actuators [45]. The current study was designed to test the feasibility of the self-reporting drug delivery aspect of the porous Si system.…”

Section: Discussionmentioning

confidence: 99%

A sustained intravitreal drug delivery system with remote real time monitoring capability

et al. 2015

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Many chorioretinal diseases are chronic and need sustained drug delivery systems to keep therapeutic drug level at the disease site. Many intravitreal drug delivery systems under developing do not have mechanism incorporated for a non-invasive monitoring of drug release. Current study prepared rugate porous silicon (pSi) particles by electrochemical etching with the currents frequency (K value) of 2.17 and 2.45. Two model drugs (Rapmycin and Dexamethasone) and two drug-loading strategies were tested for the feasibility to monitor drug release from the pSi particles through a color fundus camera. The pSi particles (k=2.45) with infiltration loading of rapamycin demonstrated progressively more violet color reflection which was negatively associated with the rapamycin released into the vitreous (r=−0.4, p<0.001, pairwise). In contrast, pSi with K value of 2.17 demonstrated progressive color change towards green and a weak association between rapmycin released into vitreous and green color abundance was identified (r=−0.23, p=0.002, pairwise). Dexamethasone was covalently loaded on to the fully oxidized pSi particles that appeared in vitreous as yellow color and fading over time. The yellow color decrease over time was strongly associated with the dexamethasone detected from the vitreous samples (r=0.7, p<0.0001, pairwise). These results suggest that engineered porous silicon particles may be used as a self-reporting drug delivery system for a non-invasive real time remote monitoring.

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Section: Discussionmentioning

confidence: 99%

A sustained intravitreal drug delivery system with remote real time monitoring capability

et al. 2015

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“…As another example of the potential of hybrid nanostructured systems, our group has fabricated magnetic porous silicon flakes from engineered nanoPS layers loaded with Fe oxide-based magnetic nanoparticles [79], following a technique previously used for the fabrication of hybrid luminescent/magnetic nanoPS particles. The special shape and magnetic configuration of the resulting particles confer very specific dynamic properties.…”

Section: Successful Application: Intraocular Diseasesmentioning

confidence: 99%

Nanostructured porous silicon-mediated drug delivery

Martín-Palma

Hernández‐Montelongo

Torres-Costa

et al. 2014

Expert Opinion on Drug Delivery

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“…A number of materials have been selected as scaffolds or supports for fabricating functional composites, including carbon materials (activated carbon, carbon nanotubes, graphite, graphene, etc. ), silica-based materials (molecular sieves and mesoporous silicon oxide), − ceramics, , and celluloses. , Using these scaffolds, a large variety of functional and well-designed architectures have been successfully developed through employing specific approaches. These assembled composites present some particular physical, chemical, electronical, or biological properties compared to the free nanomaterial counterparts and hold great promise for various applications.…”

Section: Introductionmentioning

confidence: 99%

Cellulose as a Scaffold for Self-Assembly: From Basic Research to Real Applications

Tian

2016

Langmuir

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Cellulose has received a tremendous amount of attention both in academia and industry owing to its unique structural features, impressive physical-chemical properties, and wide applications. This natural polymer is originally used for packaging, paper, lightweight composites, and so forth and is now being developed for various new areas, such as antibacterial treatment, catalysis, water purification and separation, and biological and environmental analysis. In the current article, we summarize the recent developments in the self-assembly of cellulose with various species including metal ions and metal and metal oxide nanoparticles. Then we highlight several key application areas of cellulose-based composites by reviewing the recent representative literature in each area. A significant part of this review demonstrates some exciting innovations for a wide range of practical applications of cellulose-based composites. Some challenges are also discussed with a view toward future developments.

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Design and characterization of biofunctional magnetic porous silicon flakes

Cited by 14 publications

References 29 publications

A sustained intravitreal drug delivery system with remote real time monitoring capability

A sustained intravitreal drug delivery system with remote real time monitoring capability

Nanostructured porous silicon-mediated drug delivery

Cellulose as a Scaffold for Self-Assembly: From Basic Research to Real Applications

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