Design and characterization of a passive, disposable wireless AC-electroosmotic lab-on-a-film for particle and fluid manipulation

Mirzajani, Hadi; Cheng, Cheng; Cheng, Cheng; Ivanoff, Chris S.; Aghdam, Esmaeil Najafi; Ghavifekr, Habib Badri

doi:10.1016/j.snb.2016.05.073

Cited by 54 publications

(23 citation statements)

References 51 publications

(68 reference statements)

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“…Mirzajani et al. used a double‐sided flexible copper‐clad polyimide film to design a passive, disposable wireless ACEO lab‐on‐a‐film. Hwang et al.…”

Section: Discussionmentioning

confidence: 99%

Biofluid pumping and mixing by an AC electrothermal micropump embedded with a spiral microelectrode pair in a cylindrical microchannel

Gao

2018

Electrophoresis

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In this paper, we numerically investigated a multifunctional AC electrothermal (ACET) micropump embedded with an asymmetric spiral microelectrode pair in a cylindrical microchannel for simultaneous pumping and mixing in high‐conductivity fluids, which makes the pump useful for biofluid applications. When an AC signal was applied to the asymmetric spiral electrode pair, the vortices induced on the electrode surfaces with centerlines along the corresponding spiral electrode length exhibit a spiral distribution, and the net flow in the cylindrical microchannel is generated by the ACET effect. The vorticity field distribution can explain the mechanism of simultaneous pumping and mixing. Because the vorticity field is inclined against the microchannel direction, vortices on top of the spiral electrodes can affect the ACET flow in the following two aspects at the same time: one is pumping the flow in the microchannel direction, and the other is mixing the samples by stirring the flow. We also determined that the geometric ratios of the electrode width to the gap or slant angle of the spiral electrodes can feasibly be used to control the relative strength of the pumping and mixing capabilities, and we achieved an optimal design that gives both desirable pumping and mixing efficiencies. This study shows that the spiral ACET micropump design can rapidly drive the high‐conductivity fluids and efficiently mix samples simultaneously. The numerical simulation of the spiral ACET micropump is of significant importance for practical, chemical and biological applications, and feasible fabrication techiniques should be experimentally investigated in future studies.

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“…Mirzajani et al. used a double‐sided flexible copper‐clad polyimide film to design a passive, disposable wireless ACEO lab‐on‐a‐film. Hwang et al.…”

Section: Discussionmentioning

confidence: 99%

Biofluid pumping and mixing by an AC electrothermal micropump embedded with a spiral microelectrode pair in a cylindrical microchannel

Gao

2018

Electrophoresis

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“…Our prior work on the ACEK capacitive sensing of bioparticles demonstrated that C int can effectively detect molecular deposition on the electrodes’ surfaces with low LOD and high specificity . The high specificity of this method can be illustrated by taking a closer look at the equivalent circuit of a fluidic sensor cell.…”

Section: Figurementioning

confidence: 99%

Unamplified RNA Sensor for On‐Site Screening of Zika Virus Disease in a Limited Resource Setting

Cheng

Fikrig

et al. 2017

ChemElectroChem

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Recent outbreaks of Zika virus have been declared a public health emergency of international concern. The diagnosis of Zika infection is based on a person's recent travel history, symptoms, and laboratory test results. However, the diagnosis of Zika infection may be delayed because symptoms are often mild and nondescript, and confirmatory laboratory tests are relatively time‐consuming and expensive. Given the lack of an effective vaccine against Zika virus, and a relatively short period of viremia, developing a rapid and sensitive means of detecting the Zika virus in serum is a public health priority. This work presents a novel RNA sensor, based on a sequence‐specific probe and AC electrokinetics‐enhanced capacitive sensing technology to directly capture and detect Zika virus RNA. This method allows detection and quantification of Zika virus RNA in only 30 seconds, with a low limit of detection (LOD) reaching 158.1 copies/μL. The sensor is also tested for its specificity, showing no false‐positive signals from other viruses. In addition, the biosensor is portable, inexpensive, and simple to use, without the need of signal amplification, which makes it ideal for field applications.

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“…ACEO is an effective technique for the manipulation of fluids and particles in microscale systems [1][2][3][4][5]. ACEO is defined as the flow generation in a microchannel at the surface of electrodes where low AC voltage is applied.…”

Section: Introductionmentioning

confidence: 99%

Optimization and parametric study of AC electroosmotic micropumping by response surface method

Farzanehnia

Taheri

2019

SN Appl. Sci.

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Alternative current electroosmotic micropumps (ACEO) have gained a great interest in microfluidics research due to their low operating potential. In this paper, a parametric study is performed on various geometrical parameters of an ACEO micropump design. The problem is modeled and solved numerically using COMSOL Multiphysics. This micropump relies on the grouping of a periodic electrode array in terms of the applied voltage to create asymmetries in the electrode configuration. The pumping velocity is obtained and investigated for various geometry designs. In addition, the optimal parameters are obtained by employing the response surface methodology (RSM). The RSM could predict the effects of different factors affecting the performance of the system and their interactions. The most important parameters affecting the pumping velocity are identified. It is shown that the pumping velocity is controllable. Three various micropump designs with different cost to benefit ratios are presented. These designs are different due to their fabrication cost and the pumping velocity.

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Design and characterization of a passive, disposable wireless AC-electroosmotic lab-on-a-film for particle and fluid manipulation

Cited by 54 publications

References 51 publications

Biofluid pumping and mixing by an AC electrothermal micropump embedded with a spiral microelectrode pair in a cylindrical microchannel

Biofluid pumping and mixing by an AC electrothermal micropump embedded with a spiral microelectrode pair in a cylindrical microchannel

Unamplified RNA Sensor for On‐Site Screening of Zika Virus Disease in a Limited Resource Setting

Optimization and parametric study of AC electroosmotic micropumping by response surface method

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