Design and assessment of a scintigraphy-guided biplane localization technique for breast tumours

Mena, Francisco; Mena, Iván X.; Diggles, L.; Khalkhali, Iraj

doi:10.1097/00006231-199608000-00013

Cited by 3 publications

(2 citation statements)

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“…Previous studies have examined the use of combined stereotactic biopsy devices using gamma cameras and a radioactive localization needle 17,18 or combined with x-ray mammography to perform a biopsy. 19,20 Coover et al also reported on the use of a biopsy technique for dedicated breast imaging employing radioactive markers.…”

Section: Discussionmentioning

confidence: 99%

Quantification of lesion size, depth, and uptake using a dual‐head molecular breast imaging system

Hruska

O’Connor

2008

Medical Physics

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A method to perform quantitative lesion analysis in molecular breast imaging (MBI) was developed using the opposing views from a novel dual-head dedicated gamma camera. Monte Carlo simulations and phantom models were used to simulate MBI images with known lesion parameters. A relationship between the full widths at 25%, 35%, and 50% of the maximum of intensity profiles through lesions and the true lesion diameter as a function of compressed breast thickness was developed in order to measure lesion diameter. Using knowledge of compressed breast thickness and the attenuation of gamma rays in soft tissue, a method was developed to measure the depth of the lesion to the collimator face. Using the measured lesion diameter and measurements of counts in the lesion and background breast region, relative radiotracer uptake or tumor to background ratio (T/B ratio) was calculated. Validation of the methods showed that the size, depth, and T/B ratio can be accurately measured for a range of small breast lesions with T/B ratios between 10:1 and 40:1 in breasts with compressed thicknesses between 4 and 10 cm. Future applications of this work include providing information about lesion location in patients for performing a biopsy of site and the development of a threshold for the T/B ratio that can distinguish benign from malignant disease.

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Section: Discussionmentioning

confidence: 99%

Quantification of lesion size, depth, and uptake using a dual‐head molecular breast imaging system

Hruska

O’Connor

2008

Medical Physics

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“…Mena et al [38] developed a scintigraphy-guided biopsy device on a breast phantom with a 90% rate of successful localization. Our group reported the first use of stereotactic scintigraphy localization in three patients with nonpalpable breast masses identified only by SMM at Harbor-UCLA Medical Center in Torrance, CA [39•].…”

Section: The Role Of Mibi Scintimammographymentioning

confidence: 99%

The role of nuclear medicine in breast cancer detection: A focus on technetium-99 sestamibi scintimammography

Romero

Khalkhali²,

Vargas

2003

Curr Oncol Rep

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Screening mammography in women aged over 50 years reduces breast cancer death by 30%. However, because mammography cannot accurately differentiate benign from malignant lesions, many mammography-directed breast biopsies are benign. In the past decade, methods of "functional breast imaging," including magnetic resonance imaging, scintimammography using single photon emission tomography, and positron emission tomography, have improved the sensitivity and specificity rates of conventional mammography for the detection of breast cancer. The higher specificity of scintimammography is feeding current enthusiasm for the study of its role in early breast cancer detection, as a complement to mammography in the evaluation of indeterminate lesions, and for use in noninvasive axillary staging. This article reviews the applications of radionuclide technology in breast cancer diagnosis and surveillance.

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Nuclear Medicine Advances in Breast Cancer Imaging

Bombardieri

Crippa

Baio

et al. 2001

Tumori

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Primary breast cancer imaging can be done by various means. Mammography is the most widely used technique because of its excellent diagnostic performance, patient compliance, and cost-effectiveness ratio. Other radiological techniques (such as ultrasonography) are indicated in particular circumstances, while some (such as digital mammography and magnetic resonance imaging) seem very promising but are still under evaluation. The recent technological progress in nuclear medicine has resulted in the availability of two diagnostic procedures that have been validated by extensive international clinical experience: scintimammography with Sesta-MIBI and positron emission tomography (PET) with fluorodeoxyglucose (FDG). The general advantage of nuclear medicine imaging is that tumor-seeking radiopharmaceuticals accumulate in cancer lesions, which makes scintimammography and PET fundamentally different from the radiological techniques that image the tumor mainly on the basis of morphological alterations. Scintimammography is indicated for the study of breast lesions in patients in whom mammography is non-diagnostic or difficult to interpret; it may be useful also to assess and even predict the response to primary chemotherapy. FDG-PET is increasingly used in oncology and is particularly useful in breast cancer as it gives more accurate information than scintimammography in the evaluation of patients with ambiguous mammographies and in discriminating between viable tumor, fibrotic scar or necrosis following surgery, chemo- or radiotherapy. The FDG uptake in the tumor correlates with the histological grade and potential aggressiveness of breast cancer, which may have prognostic implications. In addition to its usefulness in the study of breast lesions, FDG-PET shows great efficacy in detecting lymph node involvement prior to surgery. Whole-body PET provides information on soft tissue and bone metastases in a single scanning session, and has an important clinical role in detecting recurrent metastatic disease. On the basis of the above-mentioned evidence, nuclear medicine techniques, integrated with radiological techniques, offer an interesting opportunity to improve the diagnostic imaging yield in breast cancer, which will eventually lead to better patient management. This paper reports on the latest developments in this field.

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Design and assessment of a scintigraphy-guided biplane localization technique for breast tumours

Cited by 3 publications

References 0 publications

Quantification of lesion size, depth, and uptake using a dual‐head molecular breast imaging system

Quantification of lesion size, depth, and uptake using a dual‐head molecular breast imaging system

The role of nuclear medicine in breast cancer detection: A focus on technetium-99 sestamibi scintimammography

Nuclear Medicine Advances in Breast Cancer Imaging

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