Design and applications of carbon dots-based ratiometric fluorescent probes: A review

Chen, Binbin; Liu, Mengli; Gao, Yating; Chang, Shuai; Qian, Ruo‐Can; Li, Dawei

doi:10.1007/s12274-022-4840-2

Cited by 65 publications

(31 citation statements)

References 177 publications

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“…In addition, this technique enables real-time observation and has become an effective means of distinguishing lesion sites from normal tissues. − In the clinic, various fluorescent probes have been approved for use, such as fluorescein, , indocyanine green (ICG), and methylene blue (MB) . However, currently, almost all Food and Drug Administration (FDA) approved fluorescent probes are predominantly used for cell and mouse imaging. , Consequently, fluorescence-guided imaging technology can enable rapid and noninvasive detection of dental plaque, which plays a significant role in the early diagnosis of caries.…”

Section: Introductionmentioning

confidence: 99%

Peptide-Functionalized ZnSe:Mn Quantum Dots as Fluorescent Probes for Accurate Localization of Hidden Dental Lesion Sites

Xue

Dong

et al. 2023

ACS Appl. Nano Mater.

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Streptococcus mutans (S. mutans) is considered the primary bacteria responsible for dental caries, and specific recognition and fluorescence labeling can achieve accurate detection and early diagnosis of oral diseases such as dental caries. However, due to the weak stability of traditional imaging probes in solution and a lack of specific recognition functions, there are still significant challenges in fluorescent imaging detection of dental caries lesions. Herein, we report a peptide-QDs composite fluorescent probe that can achieve highperformance imaging of S. mutans and enable early diagnosis of the susceptible sites and hidden early carious lesions of dental caries. This fluorescent probe has high fluorescence stability, good biocompatibility, and low biotoxicity in physiological environments. It can specifically recognize and fluorescently label S. mutans, responsible for early dental caries, accurately locating dental lesion sites. Combined with visible fluorescence analysis, it is more convenient to screen for hidden dental lesions that might otherwise be ignored. Due to its low synthesis cost, stable storage, and simple imaging method, the peptide-QDs composite fluorescent probe can be widely used in routine dental examinations for accurate screening of dental diseases.

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Section: Introductionmentioning

confidence: 99%

Peptide-Functionalized ZnSe:Mn Quantum Dots as Fluorescent Probes for Accurate Localization of Hidden Dental Lesion Sites

Xue

Dong

et al. 2023

ACS Appl. Nano Mater.

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“…Generally, the fluorescence-based methods require applying dyes or modified luminescent and quenched groups to the probe and corresponding instruments [ 4 , 5 ]. Reaction conditions, such as temperature, solvent, acidity, and fluorescence quenchers, affect the intensity of fluorescent signals [ 6 ]. The lateral flow strip method is simple and rapid; however, it suffers from shortcomings, such as low throughput and high cost, and its accuracy is directly related to the specificity of the capture agent [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Tobacco Bacterial Wilt Caused by Ralstonia solanacearum by Combining Polymerase Chain Reaction with an α-Hemolysin Nanopore

Wang

Zhou

et al. 2023

Nanomaterials

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Tobacco bacterial wilt is a serious disease caused by the soil-borne bacterium Ralstonia solanacearum (R. solanacearum). Herein, a rapid and purification-free α-hemolysin (α-HL) nanopore-sensing strategy based on polymerase chain reaction (PCR) and lambda exonuclease digestion was established to detect R. solanacearum. A 198-nucleotide-long single-stranded DNA was obtained via asymmetric PCR or the lambda exonuclease-mediated digestion of the PCR product. The DNA fragment produced unique long-lived, current-blocking signals when it passed through the α-HL nanopore. This sensing approach can allow for the determination of R. solanacearum in tobacco samples and can be conveniently extended to other DNA monitoring because of the extremely wide range of PCR applications.

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“…The key to ratiometric fluorescent probe analysis has always been the design and preparation of dual emission fluorescent probes. [8] However, the prepared C-dot materials tend to have lower fluorescence properties and are more disorganized due to different synthesis processes and complex types of precursor materials, which greatly hinder the development and application of C-dots based on luminescent nanomaterials. [9] Doping carbon dots with heteroatoms is not only an effective way to enhance their photoluminescence properties [10] by tuning their surface/local chemical and electronic properties, [11] but also helps to advance theoretical research [12] and provide directions for practical applications.…”

Section: Introductionmentioning

confidence: 99%

“…The key to ratiometric fluorescent probe analysis has always been the design and preparation of dual emission fluorescent probes [8] . However, the prepared C‐dot materials tend to have lower fluorescence properties and are more disorganized due to different synthesis processes and complex types of precursor materials, which greatly hinder the development and application of C‐dots based on luminescent nanomaterials [9] .…”

Section: Introductionmentioning

confidence: 99%

A Facile Dual‐Emission Ratiometric Carbon‐Dot Fluorescent Probe and Its Application in Portable Chemical Sensors and Water Quality Analysis

Mao

et al. 2023

ChemistrySelect

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Based on the dual signal of double‐emitting carbon quantum dots (G‐CDs), a ratiometric fluorescence sensor is established to realize the analysis and detection of Fe3+ in real samples. When the excitation wavelength is 360 nm and 480 nm, the double emission fluorescence peaks are located at the wavelengths of 477 nm and 523 nm. The former is the fluorescence response signal, and the latter is the fluorescence background signal. The semi‐quantitative analysis of Fe3+ was achieved based on the linear relationship between the ratio F477/F523 of the two signals and the Fe3+ concentration. The linear range of this method is 0.015–120 μM, and the limit of detection (LOD, S/N=3) is 5 nM. Meanwhile, the naked‐eye visual detection of Fe3+ can be realized according to the fluorescence color of the probe. The probe exhibits excellent anti‐interference, selectivity and repeatability, and this method can be applied to the detection of Fe3+ in actual samples.

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Design and applications of carbon dots-based ratiometric fluorescent probes: A review

Cited by 65 publications

References 177 publications

Peptide-Functionalized ZnSe:Mn Quantum Dots as Fluorescent Probes for Accurate Localization of Hidden Dental Lesion Sites

Peptide-Functionalized ZnSe:Mn Quantum Dots as Fluorescent Probes for Accurate Localization of Hidden Dental Lesion Sites

Detection of Tobacco Bacterial Wilt Caused by Ralstonia solanacearum by Combining Polymerase Chain Reaction with an α-Hemolysin Nanopore

A Facile Dual‐Emission Ratiometric Carbon‐Dot Fluorescent Probe and Its Application in Portable Chemical Sensors and Water Quality Analysis

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