Design and analysis of MEMS based piezoelectric micro pump integrated with micro needle

Rao, K. Srinivasa; Sateesh, Jasti; Guha, Koushik; Baishnab, Krishna Lal; Ashok, P.; Sravani, K. Girija

doi:10.1007/s00542-018-3807-4

Cited by 23 publications

(14 citation statements)

References 33 publications

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“…Based on their actuation mechanisms and their construction, these devices can be divided into two groups: micropump-based and multireservoir systems. Micropump-based systems are generally embedded in microfluidic networks to control the drug release by various actuation mechanisms such as piezoelectrical pumping [59][60][61] and battery-free magnetic pumping [62][63][64] mechanisms. Multireservoir systems embedded in microchips are able to simultaneously deliver multiple drugs with differential release rates (e.g., pulsatile release) and work based on the electrochemical, electrothermal, and infrared irradiation actuation mechanisms that are applied to reservoir capping polymeric membranes.…”

Section: Microfabrication Techniquesmentioning

confidence: 99%

Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment

Geraili

Xing

Mequanint

2021

VIEW

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Section: Microfabrication Techniquesmentioning

confidence: 99%

Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment

Geraili

Xing

Mequanint

2021

VIEW

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“…Although this design offers flexibility and controllability for drug delivery platforms ( Khare and Singh, 2014 ), even reducing component dimensions, low pumping rates were achievable with either turbulent or laminar flow regimes when using this single piezoelectric element. A variation of this design in which the device is integrated with a micro-needle to deliver the pumped drug into the patient’s body was analyzed and simulated ( Rao et al, 2018 ). Reliability, biocompatibility and required fabrication procedures were considered in the election of silicon as micro-needle material.…”

Section: Implantable Mems Drug Delivery Devicesmentioning

confidence: 99%

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Mendoza

Scilletta

Bellino

et al. 2020

Front. Bioeng. Biotechnol.

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In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness and the greatest possible automation. Some of the factors that challenge conventional drug release include longterm treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile active substance administration. In this sense, the emergence of micro-devices that combine mechanical and electrical components, so called micro-electro-mechanical systems (MEMS) can offer solutions to these drawbacks. These devices can be fabricated using biocompatible materials, with great uniformity and reproducibility, similar to integrated circuits. They can be aseptically manufactured and hermetically sealed, while having mobile components that enable physical or analytical functions together with electrical components. In this review we present recent advances in the generation of MEMS drug delivery devices, in which various micro and nanometric structures such as contacts, connections, channels, reservoirs, pumps, valves, needles, and/or membranes can be included in their design and manufacture. Implantable single and multiple reservoir-based and transdermalbased MEMS devices are discussed in terms of fundamental mechanisms, fabrication, performance, and drug release applications.

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“…Piezoelectric materials have been in development for 140 years [1]. These materials are widely used in electromechanical devices because they can convert mechanical energy to electrical energy under pressure or generate mechanical motion by electricity [2,3]. The use of piezoelectric materials for the preparation of micro-electromechanical devices makes it possible to develop miniature resonators [4][5][6][7][8], frequency meters [9] and micro energy supply chips [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Composites, Fabrication and Application of Polyvinylidene Fluoride for Flexible Electromechanical Devices: A Review

Guo

Duan

Xie

et al. 2020

Preprint

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The technological development of piezoelectric materials is crucial for developing wearable and flexible electromechanical devices. There are many inorganic materials with piezoelectric effects, such as piezoelectric ceramics, aluminum nitride, and zinc oxide. They all have very high piezoelectric coefficients and large piezoelectric response ranges. The characteristics of high hardness and low tenacity make inorganic piezoelectric materials unsuitable for flexible devices that require frequent bending. Polyvinylidene fluoride (PVDF) and its derivatives are the most popular materials used in flexible electromechanical devices in recent years and have high flexibility, high sensitivity, high ductility, and a certain piezoelectric coefficient. Owing to increasing the piezoelectric coefficient of PVDF, researchers are committed to optimizing PVDF materials and enhancing their polarity by a series of means to further improve their mechanical–electrical conversion efficiency. This paper reviews the latest PVDF-related optimization materials, related processing and polarization methods, and the applications of these materials such as those in wearable functional devices, chemical sensors, biosensors, and flexible actuator devices for flexible micro-electromechanical devices. We also discuss the challenges of wearable devices based on flexible piezoelectric polymer, consider where further practical applications could be.

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Design and analysis of MEMS based piezoelectric micro pump integrated with micro needle

Cited by 23 publications

References 33 publications

Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment

Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Composites, Fabrication and Application of Polyvinylidene Fluoride for Flexible Electromechanical Devices: A Review

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