Desiccated Stomach in the Treatment of Pernicious Anemia

Sturgis, Cyrus C.

doi:10.1001/jama.1929.02710100009004

Cited by 91 publications

(7 citation statements)

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“…Site Sturgis and Isaacs (1929) in America and Wilkinson (1930) in England showed that desiccated stomach also was effective in the treatment of pernicious anaemia. Sturgis and Isaacs used fresh whole hog stomach which was desiccated so that 30 g. of the dried substance was equivalent to 190 g. of the fresh tissue.…”

Section: Prementioning

confidence: 99%

Some Aspects of the Pathology of Anaemia

Lj¹

1961

BMJ

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Section: Prementioning

confidence: 99%

Some Aspects of the Pathology of Anaemia

Lj¹

1961

BMJ

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“…Subjective symptoms, such as glossitis, paraesthesiae, and gastro-intestinal disturbances, were much more rapidly and satisfactorily relieved without the aid of the mixture of hydrochloric acid and pepsin so often necessary in liver therapy. In 1929 Sturgis, Isaacs, and Sharp,2 working independently along similar lines, reported remission in three cases, using a desiccated preparation. More recently they have made observations upon thirtynine cases of pernicious anaemia for periods up to ten eeks.3 These results have been confirm'ed by workers in other countries, but the number of cases reported has been few, while the periods of observation have not been sufficiently long to indicate the real value of this form of therapy.…”

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confidence: 93%

Treatment of Pernicious Anaemia With Hog's Stomach: Report of 108 Cases

Wilkinson¹

1931

BMJ

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“…The features of the classical, clinical and hematological response to the administration of liver (1) and of stomach (2) preparations, and recently of synthetic L. casei factor (3,4) in patients with untreated pernicious anemnia, are well known. The action of these therapeutic agents is, however, sometimes rather carelessly regarded as one of direct stimulation of blood production.…”

mentioning

confidence: 99%

Comparison of the Effects of Massive Blood Transfusions and of Liver Extract in Pernicious Anemia 1

Cs¹,

Jc²,

Rj³

et al. 1946

J. Clin. Invest.

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The features of the classical, clinical and hematological response to the administration of liver (1) and of stomach (2) preparations, and recently of synthetic L. casei factor (3, 4) in patients with untreated pernicious anemnia, are well known. The action of these therapeutic agents is, however, sometimes rather carelessly regarded as one of direct stimulation of blood production. It is perhaps more accurate to consider that liver extract acts by the replacement of a nutritional deficiency and so, in one way or another, permits effective response of the bone marrow to the stimulus of the anoxia common to all anemias. Moreover, despite an obvious analogy with the effects of iron administration in patients with hypochromic (iron deficiency) anemia, the concept that liver extract therapy in pernicious anemia also acts by abolishing a maturation arrest leading to decreased blood production has recently been challenged (5 to 7). This represents a return to the older viewpoint that the anemia is based on excessive blood destruction, manifest especially by the increased output of bile pigments in the feces. Under this hypothesis, the nutritional deficiency is assumed in some way to permit the advent of a hemolytic process (7), and the absence of elevated reticulocyte counts in the peripheral blood is explained on the hypothesis that these cells are destroyed selectively before they leave the bone marrow (5). The megaloblastic hyperplasia of that organ is thus interpreted as an unusually severe degree of the erythroid cell immaturity seen in the bone marrows of severe hemolytic anemias in animals (8) and in man (9, 10). It appeared to be desirable to secure, if possible, additional information on some of these points of view, and to attempt to distinguish between the direct effects of liver extract therapy and those due to elevations 1 The expenses of this investigation were defrayed in part by grants from the J. K. Lilly Gift to the Harvard Medical School.in hemoglobin levels following its use. Accordingly, observations were made of the comparative hematological and clinical effects of rapidly repeated transfusions, and of the administration of liver extract in pernicious anemia. METHODSFive patients with classical Addisonian pernicious anemia in relapse were selected, and were given daily transfusions of whole blood or red cell concentrates until, in 2, the red cell counts reached 3 million per cu. mm., and in 3, the red cell counts reached 5 million per cm. mm. Liver extract was then administered to the 2 patients with red cell counts of 3 million per cu. mm., and to 2 of the 3 patients with 5 million red cells per cu, mm. The remaining patient with a normal red cell value was given no further therapy for 46 days, when his red cell count had fallen to 3 million per cu. mm. Liver extract was then administered. Both during the period of transfusion, and after liver extract administration, the changes in clinical condition were observed, as well as changes in red cell count, hemoglobin concentration, corpuscular indic...

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Desiccated Stomach in the Treatment of Pernicious Anemia

Cited by 91 publications

References 4 publications

Some Aspects of the Pathology of Anaemia

Some Aspects of the Pathology of Anaemia

Treatment of Pernicious Anaemia With Hog's Stomach: Report of 108 Cases

Comparison of the Effects of Massive Blood Transfusions and of Liver Extract in Pernicious Anemia 1

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