Desgning optical waveguides for clinical diagnostics in layered tissues: Monte Carlo simulations

Designing optical waveguides for clinical diagnostics in layered tissues: experimental testing with tissue phantoms

“…Physical mechanisms responsible for the increased decay time include the increased optical path [5] and the preferential sampling of the bottom layer, which had a longer intrinsic fluorophore lifetime than the top layer. This trend was consistent with Monte-Carlo simulations [7]. Fig.…”

“…2B plots the fractional number of photons emanating from each layer as a function of p. The data were obtained by integrating the spectral contributions attributed to each fluorescent species (the emission spectra of POPOP and Rhodamine 6G were spectrally separated by � lOOnm) relative to the total integrated emission spectrum measured at each source-detector location. These data also indicated that increasing the source-detector separation p increased the fractional number of photons reaching the detector from the bottom layer, a trend consistent with Monte-Carlo simulations [7]. Importantly, these data revealed the greatest variation for clinically-relevant p values, i.e.…”