Desflurane inhibits platelet function in vitro similar to halothane

Abstract

By impairing platelet aggregation while not affecting alpha-degranulation desflurane has a differential effect on various aspects of platelet activation similar to halothane. Our results are compatible with the hypothesis of an impairment of platelet thromboxane receptor signalling by halothane. We suggest a similar mechanism for desflurane.

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“…Among the inhaled anesthetics, halothane has been known to have a property that inhibits platelet aggregation and increases bleeding time. However, desflurane also inhibits platelet function similar to halothane in an in vitro study [11]. Propofol has an effect on inhibiting human platelet aggregation and intracellular calcium increases induced by proinflammatory lipid mediators [12].…”

Comparison of the effects of desflurane and sevoflurane on the expression of platelet surface glycoproteins in unstimulated and adenosine diphosphate-induced platelets in vitro⋆

“…Huang et al [2] suggested that, because sevoflurane inhibited P-selectin expression, it might be beneficial in patients with thrombotic diseases. In considering desflurane, Berlet et al [3] showed no significant effect on the surface expression of P-selectin. Although sevoflurane did not change the expression of Pselectin, it statistically significantly decreased the expression of CD63 in unstimulated platelets.…”

“…It is usually considered that at least 80% inhibition of platelet aggregation is necessary to cause a prolongation of bleeding time [13]. Berlet at al [3] established that desflurane has an inhibitory effect on platelet aggregation. There are no data concerning the effects of desflurane on the expression of GPIIb/IIIa.…”

“…Several investigations have shown that volatile anesthetics modify aspects of platelet functions, such as in vivo bleeding time and in vitro hemostatic tests [1][2][3][4][5]. The effects on platelet function of drugs used to maintain general anesthesia are important clinical considerations [6].…”

“…The effects on platelet function of drugs used to maintain general anesthesia are important clinical considerations [6]. The effect of sevoflurane on the expression of platelet surface glycoproteins is controversial [1,3,[7][8][9][10][11][12]. Also, studies on the effect of desflurane on the expression of platelet surface glycoproteins are limited in the literature.…”