Desflurane inhibits endothelium-dependent vasodilation more than sevoflurane with inhibition of endothelial nitric oxide synthase by different mechanisms

Kazuma, Satoshi; Tokinaga, Yasuyuki; Takada, Y.; Azumaguchi, Ryu; Kimizuka, Motonobu; Hayashi, S; Yamakage, Michiaki

doi:10.1016/j.bbrc.2017.11.017

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…According to previous studies, decreases in coronary and mesenteric blood flow were observed in sevoflurane‐anesthetized animals [7, 8]. Also, impaired endothelium‐dependent vasodilation [6, 9] and marked increases in norepinephrine release [10] were found with isoflurane and sevoflurane. Moreover, the use of volatile anesthetics agents has been associated with oxidative stress and immunosuppressant and inflammatory effects [11–16].…”

Section: Introductionmentioning

confidence: 93%

“…Isoflurane and sevoflurane provide rapid induction and recovery due to low blood-gas partition coefficients but affect cardiovascular system under concentrations to induce general anesthesia [1][2][3][4][5]. Moreover, isoflurane and sevoflurane may directly affect endothelial and vascular smooth muscle function [3,6], but underlying mechanisms are unclear.…”

Section: Introductionmentioning

confidence: 99%

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Sevoflurane and isoflurane anesthesia induce redox imbalance, but only sevoflurane impairs vascular contraction

Rocha

Borges

Rodrigues

et al. 2023

Fundamemntal Clinical Pharma

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Volatile anesthetics may cause vascular dysfunction; however, underlying effects are unclear. The aim of the present study was to investigate whether sevoflurane and isoflurane affect vascular function, nitric oxide (NO) bioavailability, and biomarkers of oxidative stress and inflammation. Wistar rats were divided into three experimental groups: Not anesthetized (control group) or submitted to anesthesia with isoflurane (Iso group) or sevoflurane (Sevo group). Hemodynamic parameters were monitored during anesthesia, and blood gas values and biochemical determinants were analyzed. Isometric contractions were recorded in aortic rings. Vasoconstriction induced by potassium chloride (KCl) and phenylephrine (Phe) were measured. No differences in hemodynamic parameters and blood gasses variables were observed. Impaired KCl and Phe‐induced contractions were observed in endothelium‐intact aorta of Sevo compared to Iso and Control groups. Redox imbalance was found in Sevo and Iso groups. Reduced NO bioavailability and increased activity of matrix metalloproteinase 2 (MMP‐2) were observed in Sevo, but not in the Iso group. While reduced IL‐10 and IL‐1β were observed in Sevo, increases in IL‐1β in the Iso group were found. Sevoflurane, but not isoflurane, anesthesia impairs vasocontraction, and reduced NO and cytokines and increased MMP‐2 activity may be involved in vascular dysfunction after sevoflurane anesthesia.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Sevoflurane and isoflurane anesthesia induce redox imbalance, but only sevoflurane impairs vascular contraction

Rocha

Borges

Rodrigues

et al. 2023

Fundamemntal Clinical Pharma

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show abstract

“…Isoflurane has low solubility in blood and tissues, which results in rapid recovery of the mother and fetus [ 7 , 8 ], being less likely to cause fetal growth restriction. However, studies have been shown that isoflurane may induce cardiovascular changes including decreased cardiac contractility, altered arterial compliance [ 9 ] and interference with the vasomotor response [ 10 ]. Moreover, it has also been found that isoflurane induced nitric oxide formation [ 11 , 12 ], but the isoflurane anesthesia-induced effects are still unclear in pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Isoflurane increases the activity of the vascular matrix metalloproteinase-2 in non-pregnant rats and increases the nitric oxide metabolites in pregnancy

Souza,

Caetano,

Rodrigues

et al. 2024

Bioscience Reports

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Surgeries that require general anesthesia occur in 1.5-2% of gestations. Isoflurane is frequently used because of its lower possibility of affecting fetal growth. Therefore, we examined the isoflurane anesthesia-induced effects on maternal hemodynamic and vascular changes. We hypothesized that isoflurane would enhance endothelium-dependent vasodilation as a consequence of increased nitric oxide and decreased metalloproteinases (MMPs). Female rats (n = 28) were randomized into 4 groups (7 rats/group): conscious (non-anesthetized) non-pregnant group, non-pregnant anesthetized group, conscious pregnant group, and pregnant anesthetized group. Anesthesia was performed on the 20th pregnancy day, and hemodynamic parameters were monitored. Nitric oxide metabolites, gelatinolytic activity of MMP-2 and MMP-9, and the vascular function were assessed. Isoflurane caused no significant hemodynamic changes in pregnant compared with non-pregnant anesthetized group. Impaired acetylcholine-induced relaxations were observed only in conscious non-pregnant group (by approximately 62%) vs 81% for other groups. Phenylephrine-induced contractions were greater in endothelium-removed aorta segments of both pregnant groups (with or without isoflurane) compared with non-pregnant groups. Higher nitric oxide metabolites were observed in anesthetized pregnant in comparison with the other groups. Reductions in the 75 kDa activity and concomitant increases in 64 kDa MMP-2 isoforms were observed in aortas of pregnant anesthetized (or not) groups compared with conscious non-pregnant group. Isoflurane anesthesia shows stable effects on hemodynamic parameters and normal MMP-2 activation in pregnancy. Furthermore, there were increases in nitric oxide bioavailability, suggesting that isoflurane provides protective actions to the endothelium in pregnancy.

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Effects of anesthetics on microvascular reactivity measured by vascular occlusion tests during off-pump coronary artery bypass surgery: a randomized controlled trial

Cho

Yoo

Nam

et al. 2020

J Clin Monit Comput

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Desflurane inhibits endothelium-dependent vasodilation more than sevoflurane with inhibition of endothelial nitric oxide synthase by different mechanisms

Cited by 7 publications

References 21 publications

Sevoflurane and isoflurane anesthesia induce redox imbalance, but only sevoflurane impairs vascular contraction

Sevoflurane and isoflurane anesthesia induce redox imbalance, but only sevoflurane impairs vascular contraction

Isoflurane increases the activity of the vascular matrix metalloproteinase-2 in non-pregnant rats and increases the nitric oxide metabolites in pregnancy

Effects of anesthetics on microvascular reactivity measured by vascular occlusion tests during off-pump coronary artery bypass surgery: a randomized controlled trial

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