Desflurane and Sevoflurane in Cardiac Surgery: A Meta-Analysis of Randomized Clinical Trials

Anesthetic-induced myocardial protection in cardiac surgery: relevant mechanisms and clinical translation

“…The most recent meta-analysis [38] involved 3,966 patients from 38 trials, and reported a significant 50% reduction in mortality (1.3% vs. 2.6%) in the volatile anesthetic group versus the propofol group. Other metaanalyses have reported 47% reductions in myocardial infarction, 69% reductions in postoperative inotrope use [37], and 36.6% reductions in cardiac enzyme release [39].…”

Total Intravenous Anesthesia and Anesthetic Outcomes

“…A meta-analysis of 22 studies showed a significantly decreased rate of myocardial infarction and death in patients undergoing cardiac surgery with desflurane or sevoflurane when compared with TIVA. 29 The relative cardioprotective effect of propofol is controversial. Propofol has been reported to enhance the antioxidant capacity of erythrocytes and tissues and thereby provide dosedependent protection during ischemia and reperfusion.…”

Volatile anesthetics for lung protection: a bridge between operating rooms and intensive care units?

“…The best insights in this setting come from eight studies that showed a significant decrease in mortality when comparing IAs versus total intravenous anesthesia (TIVA) (2)(3)(4)(5)(6)(7)(8)(9).…”