"Desert Chemotypes": The Potential of Desert Plants-Derived Metabolome to Become a Sustainable Resource for Drug Leads

Ofir, Rivka

doi:10.18103/mra.v8i7.2169

Cited by 3 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that soil-and plant-associated microbiomes could function as biofertilizers and biocontrol agents to enhance soil hydraulic properties 11 , fertility, plant stress tolerance, and productivity [12][13][14][15] . Studies on desert metabolites focused on plant-and endophytes-derived metabolites, which are important for environmental adaptation and drug discovery 16,17 . However, fewer studies focused on the dynamics and functional role of soil microbiome during long-term desert ecosystem restoration.…”

Section: Introductionmentioning

confidence: 99%

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

Chen,

Yuan,

Jiang

et al. 2023

Preprint

View full text Add to dashboard Cite

SummaryEcological restoration of degraded lands is essential to human sustainability. Yet, an in-depth community, functional, and evolutionary microbial perspective of long-term restoration of damaged ecosystems is lacking. Herein, we comprehensively assessed the impact of long-term (up to 17 years) restoration of Tengger Desert, China, by multi-omic profiling of 1,910 topsoil samples. The soil biophysiochemical properties, especially soil hydraulics, microbiome stability, and functional diversity, significantly improved during restoration. The soil microbiome transitioned from an extreme oligotrophic and autotrophic community to a diverse copiotrophic ecosystem. The soil microbiota, including fungi, could mediate the soil physicochemical changes through metabolites. Importantly, the systematic rewiring of nutrient cycles featured the multi-domain preference of an efficient carbon fixation strategy in the extreme desert environment. Finally, the microbiome was evolving via positive selections of genes of biogeochemical cycles, resistance, and motility. In summary, we present a comprehensive community, functional, biogeochemical, and evolutionary landscape of the soil microbiome during the long-term restoration of desert environments. We highlight the crucial microbial role in restoration from soil hydraulic and biogeochemical perspectives, offering promising field applications.HighlightsThe desert soil microbiome transformed from simple oligotrophic to a diverse, stable, and nutrient-rich ecosystem with expanded functional diversity.Restoration led to systematically rewired biogeochemical cycles, which are highly efficient in carbon fixation in the desert environment.The microbiome was evolving via positive selections of genes involved in biogeochemical cycles and environmental adaptations.Microbes and metabolites could facilitate desert restoration from hydraulic and biogeochemical aspects, offering promising field applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

Chen,

Yuan,

Jiang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Analysis of herbal medicine among Bedouin of the Saint Catherine Protectorate (southern Sinai Peninsula) and its comparison to modern drug design

Ofir,

Lev,

Ron

et al. 2023

Sustainable Environment

View full text Add to dashboard Cite

Anticancer Activity of Secondary Metabolites Present in Plants of Hot Arid Region of India

Vashishth

Yadav

Bhardwaj

et al. 2023

NPJ

View full text Add to dashboard Cite

Cancer a death havoc is increasing at an alarming pace globally. There is a need to explore novel chemicals having anticancerous potential for its treatment with minimal side effects. Natural compounds obtained from plants have less toxic properties and can be proved as a better medication against this lethal disease. Thus, the secondary metabolites having anticancer properties found in plants, fruits, and vegetables are being persistently evaluated for research in cancer treatment like anticancer drugs- vinblastine, vincristine and taxol which are derived from plants. This review summarizes the anticancer properties of chemical repertoires of plants inhabiting the hot arid regions present in India against various cancer cell lines like HepG2, MCF7, PC3, HT116 etc. The mechanism of action of flavonoids in the induction of apoptosis through suppression/promotion of various factors including Ras-ERK and PI3K-Akt signaling pathways and genes mainly such as Bax, Bcl-2, p53 involved in the proliferation of cancer cells play emphatically in combating the extent of the disease by promoting apoptosis in cancer cells. The insight about the reported mechanisms will open further avenues of the anticancer potential of novel secondary metabolites.

show abstract

"Desert Chemotypes": The Potential of Desert Plants-Derived Metabolome to Become a Sustainable Resource for Drug Leads

Cited by 3 publications

References 14 publications

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

Analysis of herbal medicine among Bedouin of the Saint Catherine Protectorate (southern Sinai Peninsula) and its comparison to modern drug design

Anticancer Activity of Secondary Metabolites Present in Plants of Hot Arid Region of India

Contact Info

Product

Resources

About