Desenvolvimento pós-natal e potencial teratogênico da prole de ratos Wistar no estudo da toxicidade reprodutiva de duas preparações fitoterápicas contendo soja Glycine max (L.) Merr

Hollenbach, Clarissa Boemler; Bortolini, Carlos Eduardo; Batista, João M.; Hollenbach, Emanuel Boemler; Schuch, Tatiana Larissa; Pacheco, Maíra Haase; Mello, Fernanda Bastos de; Mello, João Roberto Braga de

doi:10.1590/s0102-09352010000400013

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Moreover, the histological analysis of the testes revealed that the pattern of organization of the seminiferous epithelium presented no obvious changes and that the overall morphology was maintained normal in the treated groups. The perinatal and postnatal development potential depends on the subjects and their ability to meet varied environmental conditions (Hollenbach et al, 2010). There is a need for longitudinal studies concerning the reproductive toxicology covering not only structural but also functional changes, such as the development of physical characteristics from the first days of life and even animal behavior (Hollenbach et al, 2010).…”

Section: Tablementioning

confidence: 99%

“…The perinatal and postnatal development potential depends on the subjects and their ability to meet varied environmental conditions (Hollenbach et al, 2010). There is a need for longitudinal studies concerning the reproductive toxicology covering not only structural but also functional changes, such as the development of physical characteristics from the first days of life and even animal behavior (Hollenbach et al, 2010). According to Peters and Guerra (1995), a normal postnatal development is generally observed when the percentage of surviving newborns and their growth are similar to those obtained in control animals.…”

Section: Tablementioning

confidence: 99%

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Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats

Gonçalves¹,

Silva²,

Gomes³

et al. 2014

Revista Brasileira de Farmacognosia

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Section: Tablementioning

confidence: 99%

Section: Tablementioning

confidence: 99%

Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats

Gonçalves¹,

Silva²,

Gomes³

et al. 2014

Revista Brasileira de Farmacognosia

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Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis

Silva¹,

Marinho

Silva³

et al. 2017

BioMed Research International

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Studies about toxicological potential of usnic acid are limited. This way, the vast majority of data available in the literature are related only to biological activities. This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis. Females rats were distributed in the control groups, treated I and II, at doses of 15 and 25 mg/kg, administered by gavage during the 6° to 15° days of pregnancy. After 20 days the fetuses were removed and analyzed. A reduction in weight gain during pregnancy, increased resorption, reduction in the number of viable fetuses, and their body weight were observed. Morphological changes in the litter were visualized as exposure of the eye and atrophy of the limbs at the dose of 25 mg/kg. Histological analysis of the liver of the fetus showed reduction in the number of megakaryocytes between experimental groups and increase in the number of hepatocytes in a dose of 25 mg/kg. The experimental model used in this study reveals teratogenic effect of usnic acid in the period of organogenesis. Since this achievement, the importance of evaluating the toxic effects of natural substances is imperative, in order to elucidate the care in their indication as drug.

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Desenvolvimento pós-natal e potencial teratogênico da prole de ratos Wistar no estudo da toxicidade reprodutiva de duas preparações fitoterápicas contendo soja Glycine max (L.) Merr

Cited by 2 publications

References 9 publications

Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats

Effects of the oral treatment with Copaifera multijuga oil on reproductive performance of male Wistar rats

Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis

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