Desenvolvimento de um método simples e rápido para determinação de bisfenol A em amostras de papéis por espectroscopia de fluorescência sincronizada

Abstract

Bisphenol A (BPA) is used in a variety of consumer products, including some paper products, particularly thermal receipt papers, for which it is used as a color developer. Nevertheless, little is known about the magnitude of BPA contamination or human exposure to BPA as a result of contact with papers. In this study, was develop and validate an methodology for determination of BPA by synchronous fluorescence spectroscopy. The developed and validated method was fast, easy, low cost, with a good sensibility and appropriate for application in paper samples. The method was linear on the range of to 25 a 450 µg.L -1 (r = 0,9993). The detection and quantification limits were 1,20 and 3,99 µg.L -1 respectively. Inter and intraday precision were between 3,21 to 8,54% and 0,29 to 3,92%, respectively. Accuracy was between 87,4 to 111%.The recovery was between 100 to 102 % (extracted samples). The validated methodology was applied in the BPA determination in 13 types pf paper products (n=444), including thermal receipt papers (n=341), lottery tickets (n=7), bus tickets (n=5), business cards (n=12), mailing envelopes (n=11), flyers (n=10), napkins (n=8), printing paper (n=3), food contact paper (n=20), kitchen rolls (n=4), toilet paper (n=8), newspaper (n=6), and magazines (n=9). BPA was found in 98% of thermal receipt papers (n = 341) at concentrations ranging from below the limit of quantitation (LOQ) to 27,7 mg.g -1 with a geometric mean of 14,6 mg.g -1 and a median of 17,7 mg.g -1 . The majority (96%) of other paper products (n = 103) contained BPA at concentrations ranging from below the LOQ to 379 µg.g -1 with a geometric mean of 14,7 µg.g -1 and a median of 17,3 µg.g -1 . Whereas thermal receipt papers contained the highest concentrations of BPA (milligram-per-gram), the others types of papers, especially those produced from recycled paper contain lower concentrations of BPA (microgramper-gram). Estimation of human exposure to BFA through manipulation of different paper types was calculated based on the measure of concentration and frequency of manipulation. The estimated daily intake for BFA adjusted body weight (calculated at median concentrations) through dermal absorption from handling of papers was 14.5and 1070 ng/day for the general population and occupationally exposed individuals, iv respectively.