Desenvolvimento de nanopartículas de poli (&lt;i&gt;n&lt;/i&gt;-butil-cianoacrilato) com zidovudina revestidas por ácido hialurônico para veiculação em gel de uso transdérmico

Guimarães, Marcelo

doi:10.11606/t.9.2016.tde-16032016-101157

Cited by 1 publication

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References 39 publications

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“…Several nanotechnological stratagies, such as polymeric nanoparticles, allow substances with different properties to be applied in the same formulation, making it possible to alter the properties and behaviour of a given substance in a biological environment (BON-IFÁCIO et al, 2014;GUTERRES, et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoparticles containing Tithonia diversifolia (hemsl) a. Gray flowers alcoholic extract and coated by hyaluronic acid_ development, synthesis, and characterization

Rezende¹,

Ruocco²,

Silva³

et al. 2020

Braz. J. Nat. Sci

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Nanoparticles are systems formed by biodegradable, synthetic or natural polymers, that have gained significant importance in different industry segments, as well as being the highlight of essential researches. These tiny particles present various promising characteristics, such as: site-specific and gradual drug release and improvement of active principle solubility and stability. The combination of nanotechnology with medicinal plants could be able to enhance the action of plant extracts, such so that many innovative drug carriers have emerged, including polymeric nanoparticles. The objective of this study was to synthesize and characterize polymeric nanoparticles coated with hyaluronic acid, containing Tithonia diversifolia (Hemsl) A. Gray flowers alcoholic extract, aiming to improve the nanoparticle’s stability, for possible future applications. The synthesis occurred through emulsion polymerization, where the monomer n-butyl-cyanoacrylate was incorporated with Dextran® into an aqueous HCl solution, with posterior addition of the alcoholic plant extract and neutralization reaction with NaOH. Stability parameters, such as hydrodynamic diameter, polydispersity index, zeta potential, spectroscopy (IV), Scanning Electron Microscopy (SEM), thermogravimetry (TG) and Differential Exploration Calorimetry (DSC) were analysed. The nanoparticle system was evaluated taking into consideration particle stability prior and posterior to the addition of the extract, as well as coated and uncoated particles. The results demonstrated the good reactivity of the monomers of cyanoacrylates, as well as effectiveness of hyaluronic acid in relation to the proposed objective, evidenced in the results obtained by Infrared Spectroscopy, by SEM, DSC and, also, TG. The study demonstrated that there are possible future applications for this method.

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Section: Introductionmentioning

confidence: 99%