Desenvolvimento de matrizes poliméricas biodegradáveis à base de quitosana e possíveis blendas como sistemas de liberação controlada de fármacos

Abstract

Dissertação apresentada como parte dos requisitos para obtenção do Grau de ABSTRACTAccording to the concept of drug delivery systems, this study has based on the use of biocompatible hydrophilic polymers hydrogels-forming for the development of matrices in the form of thin films. The polymers used for forming the matrices were chitosan from shrimp shells, modified maize starch and poly(N-vinyl-2-pyrrolidone) -PVP. The matrices were cross-linked using glutaraldehyde. The drug chosen to test the ability of the devices release was the non-steroidal anti-inflammatory drug (NSAID) sodium diclofenac. Mixtures between chitosan-starch and chitosan-PVP tested to obtain the matrices with suitable properties for this purpose. The devices after qualitative screening had evaluated for cytotoxicity, maximum swelling, gel fraction, kinetic parameters associated with absorbing water vapor and the release of diclofenac sodium able to in vitro. The formulations based on chitosan-PVP were the presents the best properties, in evidence formulation A3, with high percentage of delivery, good handing properties, few compounds/components reducing the allergenic potential and successful in vitro cell viability red uptake cytotoxicity assay, using cell culture mouse cells (NCTC).

Development of Gelatin/Misoprostol Compounds for Use in Pregnancy Failures

“…The degree of swelling of a material can be defined as the amount of solvent absorbed by it. This property is related to the structure of the network formed in the crosslinks in the polymerization and crosslinking process of the polymer, observed through the crosslinking density [ 17 ]. The expansion capacity of biomaterials is an important aspect to evaluate their properties when applied as controlled drug delivery systems [ 18 ].…”