Desenvolvimento de formulações cosméticas contendo pantenol e avaliação dos seus efeitos hidratantes na pele humana por bioengenharia cutânea

Junior, Camargo; de, Flavio Bueno

doi:10.11606/d.60.2006.tde-17012007-143439

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…The rheological characterization of the formulations and the evaluation of the viscosity, flow index, consistency index and thixotropy allow a better understanding of the physico-chemical nature of formulations in the development phase. In addition, it allows to control the quality of raw materials and finished products, to evaluate the effect of the consistency of the product on the release and skin penetration, besides contributing to the prediction of the shelf life of the product (31). The formulations did not show significant variation in the flow index during the study time, and presented flow index lower than 1, which indicates pseudoplastic behavior.…”

Section: Physical Stability-rheological Assessmentmentioning

confidence: 99%

Development of Topical Formulations Containing 20% of Coated and Uncoated Zinc Oxide Nanoparticles: Stability Assessment and Penetration Evaluation by Reflectance Confocal Laser Microscopy

Cuelho,

Assis,

Fonseca

et al. 2023

Preprint

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The introduction on Zinc oxide nanoparticles (ZnOn) in sunscreens solved the issue of poor spreadability of these formulations, which often left a white film on the skin. However, safety concerns have arisen regarding the topical application of ZnOn. Some studies employed commercial sunscreens to address the safety issues of the topical application of ZnOn; however, commercial formulations are often complex and contain a wide range of ingredients that could attenuate the potential damage caused by the ZnOn. Therefore, in this study we aimed to develop a simple stable formulation containing 20% of coated and uncoated ZnOn, characterize the formulations and the nanoparticles, and assess the skin penetration in Franz diffusion cell. The Feret's diameter for the uncoated and coated ZnOn was 137 nm and 134 nm, respectively. For the uncoated ZnOn the hydrodynamic size in water was 368 nm and for the coated ZnOn, the average hydrodynamic size in ethyl acetate was 135 nm. The incorporation of ZnOn led to formulations more consistent and easier to spread, as suggested by the lower work of shear and higher values of firmness, cohesiveness, consistency and index of viscosity compared with the vehicle. The stability assessment at 45ºC suggested that the formulations containing the ZnOn were stable for 30 days and the vehicle was stable for 90 days. The assessment off the skin penetration by reflectance confocal laser microscopy indicated that the formulations did not permeate into the deepest layers of the skin, but accumulated on the skin furrows, hair and hair follicle.

show abstract

Section: Physical Stability-rheological Assessmentmentioning

confidence: 99%

Development of Topical Formulations Containing 20% of Coated and Uncoated Zinc Oxide Nanoparticles: Stability Assessment and Penetration Evaluation by Reflectance Confocal Laser Microscopy

Cuelho,

Assis,

Fonseca

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The rheological characterization of the formulations and the evaluation of the viscosity, flow index, consistency index and thixotropy allow a better understanding of the physicochemical nature of the formulations in the development phase. In addition, it allows the control of the quality of raw materials and finished products, to evaluate the effect of the consistency of the product on the release and skin penetration, besides contributing to the prediction of the shelf life of the product [31]. The formulations did not show significant variations in the flow index during the study time, and presented a flow index lower than 1, which indicates pseudoplastic behavior.…”

Section: Physical Stability-rheological Assessmentmentioning

confidence: 99%

Development of Topical Formulations Containing 20% of Coated and Uncoated Zinc Oxide Nanoparticles: Stability Assessment and Penetration Evaluation by Reflectance Confocal Laser Microscopy

Assis Dias Alves,

Cuelho,

Fonseca

et al. 2023

Cosmetics

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The introduction of zinc oxide nanoparticles (ZnOn) in sunscreens solved the issue of poor spreadability of these formulations, which often left a white film on the skin. However, safety concerns have arisen regarding the topical application of ZnOn. Some studies employed commercial sunscreens to address the safety issues of the topical application of ZnOn; however, commercial formulations are often complex and contain a wide range of ingredients that could attenuate the potential damage caused by the ZnOn. Therefore, in this study we aimed to develop a simple stable formulation containing 20% of coated and uncoated ZnOn, characterize the formulations and the nanoparticles, and assess the skin penetration in a Franz diffusion cell. The Feret’s diameter for the uncoated and coated ZnOn was 137 nm and 134 nm, respectively. For the uncoated ZnOn the hydrodynamic size in water was 368 nm and for the coated ZnOn, the average hydrodynamic size in ethyl acetate was 135 nm. The incorporation of ZnOn led to formulations more consistent and easier to spread, as suggested by the lower work of shear and higher values of firmness, cohesiveness, consistency and index of viscosity compared with the vehicle. The stability assessment at 45 °C suggested that the formulations containing the ZnOn were stable for 30 days and the vehicle was stable for 90 days. The assessment of the skin penetration by reflectance confocal laser microscopy indicated that the ZnOn did not permeate into the deepest layers of the skin, but accumulated on the skin furrows, hair and hair follicles.

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“…Após calibração do eletrodo com solução tampão 4,0 e 7,0, a medida foi realizada em duplicada em potenciômetro digital utilizando-se amostras diluídas a 10% em água purificada (CAMARGO JUNIOR, 2006;BRASIL, 2008).…”

Section: Determinação De Phunclassified

Avaliação Da Atividade Antioxidante Da Espécie Capparis Flexuosa L. E O Seu Uso Em Gel

Monteiro¹,

Silva²,

Pitanga³

et al. 2020

Pesquisa, Produção E Difusão De Conhecimentos Nas Ciências Farmacêuticas 2

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Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação. A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Desenvolvimento de formulações cosméticas contendo pantenol e avaliação dos seus efeitos hidratantes na pele humana por bioengenharia cutânea

Cited by 5 publications

References 29 publications

Development of Topical Formulations Containing 20% of Coated and Uncoated Zinc Oxide Nanoparticles: Stability Assessment and Penetration Evaluation by Reflectance Confocal Laser Microscopy

Development of Topical Formulations Containing 20% of Coated and Uncoated Zinc Oxide Nanoparticles: Stability Assessment and Penetration Evaluation by Reflectance Confocal Laser Microscopy

Development of Topical Formulations Containing 20% of Coated and Uncoated Zinc Oxide Nanoparticles: Stability Assessment and Penetration Evaluation by Reflectance Confocal Laser Microscopy

Avaliação Da Atividade Antioxidante Da Espécie Capparis Flexuosa L. E O Seu Uso Em Gel

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