Desensitization to acetazolamide in a patient with previous antimicrobial sulfonamide allergy

There do not appear to be consistent genetic markers to reliably predict features of or the presence hypersensitivity reactions. Recent evidence continues to alleviate early concerns cross-reactivity between sulfonamide antibiotics and non-antibiotics. Sulfonamide drug allergy is frequently encountered by the practicing clinician. For sulfonamide antibiotics, delayed rash is the most common clinical manifestation. There is no current evidence to support avoidance of all non-antibiotic sulfonamides in those with a reported allergy to sulfonamide antibiotics, although certain scenarios require caution. Available evidence supports the cautious reintroduction of sulfonamide antibiotics via desensitization, which is usually well tolerated and should be considered in those with strong indications for trimethoprim-sulfamethoxazole and a reported sulfonamide allergy.

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Sulfonamide Drug Allergy

Dorn

Alpern

McNulty

et al. 2018

Curr Allergy Asthma Rep

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Acetazolamide

2017

Reactions Weekly

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Rapid oral desensitization protocol to abiraterone acetate

Verdú¹,

Torres-Degayon²,

Hassan-Bennis³

2018

Annals of Allergy, Asthma & Immunology

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Desensitization to acetazolamide in a patient with previous antimicrobial sulfonamide allergy

Cited by 5 publications

References 5 publications

Sulfonamide Drug Allergy

Sulfonamide Drug Allergy

Acetazolamide

Rapid oral desensitization protocol to abiraterone acetate

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