Descriptive Information of Topographic Parameters Computed at the Optic Nerve Head with the Heidelberg Retina Tomograph

Saruhan, Ayhan; Orgül, Selim; Koçak, İncí; Prünte, Christian; Flammer, Josef

doi:10.1097/00061198-199812000-00012

Cited by 39 publications

(16 citation statements)

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“…However, all absolute measurements of the RTA differ from those obtained by HRT, which is obvious for the optic disc size. Much higher values are obtained (mean 2.92 mm 2 ) as compared to HRT, which has a mean disc size of 1.81 mm 2 [26] . However, this does not question the accuracy of RTA measurements as it is well known that HRT measurements underestimate the size compared to photographic methods [27,28] .…”

Section: Discussionmentioning

confidence: 80%

Age Effect on Retina and Optic Disc Normal Values

Neubauer

Chryssafis²,

Thiel³

et al. 2005

Ophthalmic Res

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Purpose: To investigate retinal thickness and optic disc parameters by the Retinal Thickness Analyzer (RTA) glaucoma program in older normal subjects and to determine any age effect. Methods: Subjects over 40 years of age without any prior history of eye diseases were recruited. Only subjects completely normal on clinical ophthalmologic examination and on visual field testing by Humphrey Field Analyzer (HFA) using the SITA 24-2 program were included. A total of 74 eyes from 74 subjects with even age distribution over the decades were enrolled and underwent topographic measurements of the posterior pole and of the optic disc by RTA. The ‘glaucoma full’ program in software version 4.11B was applied. Results: Mean patient age was 59.9 ± 10.3 years with a range from 40 to 80 years. The only parameter intraocular pressure (IOP) correlated with was retinal posterior pole asymmetry (r = 0.27, p = 0.02). IOP itself increased significantly with age (r = 0.341, p = 0.003). Mean defect and pattern standard deviation of the HFA did not correlate with any of the retinal or optic disc measurements. Increasing age correlated significantly with some of the morphologic measurements of the RTA: decreasing perifoveal minimum thickness (r = –0.258, p = 0.026), increased cup-to-disc area ratio (r = 0.302, p = 0.016) and increased cup area (r = 0.338 p = 0.007). Conclusions: An age effect exists for some of the retina and optic disc measurements obtained by the RTA.

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Section: Discussionmentioning

confidence: 80%

Age Effect on Retina and Optic Disc Normal Values

Neubauer

Chryssafis²,

Thiel³

et al. 2005

Ophthalmic Res

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“…45 However, because of the principal of regression to the mean, limiting the number of acquired topographic images to one image per eye is Eye not expected to alter the results in a screening procedure such as the one described here. 46 During the imaging procedure, the subjects fixated on a distant target with the fellow (non-test) eye. For the topographic images, the optic disc margin was outlined along the inner margin of the scleral ring by an experienced investigator (DG).…”

Section: Ocular Perfusion Measurementsmentioning

confidence: 99%

First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study

Gherghel

Hosking

Cunliffe

et al. 2006

Eye

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Purpose To evaluate the effect of latanoprost 0.005% on the optic nerve head (ONH) and retinal circulation of newly diagnosed and previously untreated primary open-angle glaucoma (POAG) patients. Methods Twenty-two newly diagnosed and previously untreated POAG patients (mean age7SD: 68.38711.92 years) were included in this longitudinal open-label study. Patients were treated with latanoprost 0.005% once a day. Intraocular pressure (IOP), systemic blood pressure (BP), mean ocular perfusion pressure (MOPP), and ocular perfusion parameters 'volume', 'velocity', and 'flow' measured at the optic nerve head (ONH) and retina by means of Heidelberg Retina Flowmeter system were evaluated during a 6-month follow-up period. Results Treatment with latanoprost 0.005% resulted in a significant decrease in IOP (Po0.0001) and increase in MOPP (Po0.0001). After correcting for changes in MOPP, the blood velocity measured at the ONH level was significantly higher after 6 months of treatment than at baseline (P ¼ 0.0310). In addition, blood volume and flow measured at the peripapillary retina level improved after 3 and 6 months of treatment (P ¼ 0.0170; P ¼ 0.0260, and P ¼ 0.0170; P ¼ 0.0240 respectively).Conclusion Previously untreated POAG patients exhibit reduced IOP, increased MOPP and improved ocular perfusion at the ONH and retina levels when treated with Latanoprost 0.005%. These effects could be beneficial for glaucoma patients suffering from ocular vascular dysregulation.

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“…1,15 Although several studies have described the optic nerve head topography obtained with the HRT in normal white subjects, 15,16 little is known about the topographic characteristics of optic discs of normal Japanese subjects. Moreover, little is known regarding the factors contributing to the characteristics of the optic disc or the symmetry of the disc sectors in the Japanese population.…”

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confidence: 99%