Descriptive epidemiology of 13,038 newly diagnosed and histologically confirmed meningiomas in France: 2006–2010

To analyse the outcome of patients with WHO grade II meningioma and identify factors that may influence recurrence and survival. Between January 2007 and September 2015, a retrospective search identified 194 WHO grade II meningiomas at the National Hospital for Neurology and Neurosurgery, London. Survival methods were implemented. 31 patients (16 %) had a previous history of grade I meningioma. The patients underwent a total of 344 surgical resections and 43.3 % received radiotherapy. 55 patients (28.4 %) had been re-operated on for a WHO grade II meningioma relapse. Median follow-up was 4.4 years. At the end of the study, 75 patients (40.1 %) had no residual tumour on the last scan. Surgical recurrence free survival at 5 years was 71.6, 95 % CI [63.5, 80.8]. Secondary grade II meningioma (HR = 2.29, p = 0.010), and, Simpson resection grade 1, 2 and 3 vs. 4 and 5 (HR = 0.57, p = 0.050) were associated with the surgical recurrence-free survival. 32 died from meningioma (16.5 %). Overall survival probability at 5 years was 83.2, 95 % CI [76.6, 90.4]. Age at diagnosis (HR = 0.22, p < 0.001), WHO grade I meningioma progressing into grade II (HR = 3.2, p = 0.001), tumour location (HR = 0.19, p < 0.001), and mitosis count (HR = 0.36, p = 0.010) were independently associated with the overall survival. Patients who received radiotherapy demonstrated neither a reduced risk of recurrence nor a longer overall survival (p = 0.310). In our series shorter survival correlated with older age, increased mitoses, progression from grade I to II and location. We were not able to demonstrate a significant improvement in any of the clinical outcomes after radiotherapy.

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“…36 patients (18.6 %), mostly from overseas, were lost often in women and are associated with a relatively good outcome [3].…”

Section: Population Descriptionmentioning

confidence: 99%

WHO grade II meningioma: a retrospective study for outcome and prognostic factor assessment

et al. 2016

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“…The incidence of NBM varies between different races, genders and areas [5][6][7]. The introduction of the new WHO classification in 2000, and the newer classification in 2007, caused a shift in the epidemiology of benign meningioma as well as NBM [8,9]. The incidence of WHO Grade II meningioma increased, and that of WHO III meningioma did not significantly change [10].…”

Section: Introductionmentioning

confidence: 99%

Review of controversies in management of non-benign meningioma

Paldor

Awad

Sufaro

et al. 2016

Journal of Clinical Neuroscience

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“…Among these, metaplastic meningioma is among the rarest. In 2018, Zouaoui and colleagues [ 22 ] reported a nationwide descriptive epidemiology of meningioma. In their 15-year study in France, the incidence of metaplastic meningioma was 0.04% (62 of 13038 newly diagnosed and histologically confirmed meningioma).…”

Section: Discussionmentioning

confidence: 99%

“…During our 15-year study period, WHO grade I meningioma accounted for 1376 (75.9%) cases : 354 (19.5%) and 84 (4.6%) cases were WHO grades II and III, respectively. The two epidemiologic studies described above reported 89.2% and 91.9% WHO grade I, 9.3% and 5.2% WHO grade II, and 1.5% and 2.9% WHO grade III meningioma, respectively [ 20 , 22 ]. Thus, our incidence rates of WHO grades II and III meningiomas appear slightly higher than those reported previously.…”

Section: Discussionmentioning

confidence: 99%

Intracranial Metaplastic Meningioma : Clinical and Radiological Characteristics of 11 Cases

Kim¹,

Kim²,

Ji³

et al. 2020

J Korean Neurosurg Soc

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Objective Metaplastic meningioma is an extremely rare subtype of World Health Organization (WHO) grade I meningioma. It has distinctive histological subtypes according to its own mesenchymal components. Owing to its scarcity, clinical or radiological features of a metaplastic meningioma are poorly described. Methods Between 2004 and 2018, we analyzed total 1814 cases surgically proven meningioma for 15 years. Among them, metaplastic meningioma was diagnosed in 11 cases. Magnetic resonance images were taken for all patients, and computed tomography scan was taken for 10 patients. Results WHO grade I meningiomas were 1376 cases (75.9%), 354 cases (19.5%) in WHO grade II, and 84 cases (4.6%) in WHO grade III meningiomas. Metaplastic meningioma was 11 cases as 0.8% of WHO grade I meningioma and 0.6% of entire meningiomas for 15 years. Among the entire 11 metaplastic meningiomas, five tumors (45%) were diagnosed as a lipomatous subtype with rich fat components, four (36%) as an osseous subtype with extensive bone formation and two (18%) as a xanthomatous subtype. There was no cartilaginous subtype metaplastic meningioma in our study. Lipomatous and osseous metaplastic meningioma have peculiar radiological characteristics according to mesenchymal components. Conclusion We investigated a rare metaplastic meningioma subtype based on our 15-year surgical experience with meningiomas. Further investigation will be necessary for the clear clarification of tumor nature of this rare tumor.

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Descriptive epidemiology of 13,038 newly diagnosed and histologically confirmed meningiomas in France: 2006–2010

Cited by 68 publications

References 22 publications

WHO grade II meningioma: a retrospective study for outcome and prognostic factor assessment

WHO grade II meningioma: a retrospective study for outcome and prognostic factor assessment

Review of controversies in management of non-benign meningioma

Intracranial Metaplastic Meningioma : Clinical and Radiological Characteristics of 11 Cases

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