Descriptive anatomy of Heschl’s gyri in 430 healthy volunteers, including 198 left-handers

Marié, Damien; Jobard, Gaël; Crivello, Fabrice; Perchey, Guy; Petit, Laurent; Mellet, Emmanuel; Joliot, Marc; Zago, Laure; Mazoyer, Bernard; Tzourio‐Mazoyer, Nathalie

doi:10.1007/s00429-013-0680-x

Cited by 105 publications

(91 citation statements)

References 70 publications

(127 reference statements)

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“…A similar observation (i.e., of a greater frequency of H2 gyri) has been reported before in individuals with dyslexia, although not specifically in the right hemisphere [Leonard et al, ]. A few studies have shown that the morphology of Heschl's gyri is highly variable in the general population [Leonard et al, ; Marie et al, ; Penhune et al, ]. Additionally, it has been suggested that duplications in the left hemisphere might be related to better skills in phonetic learning and in the auditory processing of speech [Golestani et al, ].…”

Section: Discussionsupporting

confidence: 71%

Planum temporale asymmetry in developmental dyslexia: Revisiting an old question

et al. 2014

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Among the various asymmetrical structures of the human brain, the planum temporale, an anatomical region associated with a variety of auditory and language-related processes, has received particular attention. While its surface area has been shown to be greater in the left hemisphere compared to the right in about two-thirds of the general population, altered patterns of asymmetry were revealed by post mortem analyses in individuals with developmental dyslexia. These findings have been inconsistently replicated in magnetic resonance imaging studies of this disorder. In this report, we attempt to resolve past inconsistencies by analyzing the T1-weighted MR images of 81 children (mean age: 11 years, sd: 17 months), including 46 control (25 boys) and 35 dyslexic children (20 boys). We manually outlined Heschl's gyri, the planum temporale and the posterior rami of the Sylvian fissure on participants' brain images, using the same anatomical criteria as in post mortem studies. Results revealed an altered pattern of asymmetry of the planum temporale surface area in dyslexic boys only, with a greater proportion of rightward asymmetrical cases among dyslexic boys compared to control boys. Additionally, analyses of cortical thickness showed no asymmetry differences between groups for any of the regions of interest. Finally, a greater number of Heschl's gyrus full duplications emerged for the right hemisphere of dyslexic boys compared to controls. The present findings confirm and extend early post mortem observations. They also stress the importance of taking gender into account in studies of developmental dyslexia.

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Section: Discussionsupporting

confidence: 71%

Planum temporale asymmetry in developmental dyslexia: Revisiting an old question

et al. 2014

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“…Heschl’s gyrus may be a case in point here. This region demonstrated high variability across all 3 cortical metrics in the current study, and other research has documented strong individual variability within this region using various anatomical methods (e.g., Warrier et al, 2009; Marie et al, 2015). Heschl’s gyrus anatomical asymmetry is related to functional asymmetry of auditory processing (Tzourio-Mazoyer et al, 2015; Warrier et al, 2009), and anatomical variation of this region is associated with experiential differences in bilingual language exposure (Ressel et al, 2012), and musical training (Hyde et al, 2009).…”

Section: Discussionsupporting

confidence: 63%

Structural asymmetry of the human cerebral cortex: Regional and between-subject variability of surface area, cortical thickness, and local gyrification

et al. 2016

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Structural asymmetry varies across individuals, brain regions, and metrics of cortical organization. The current study investigated regional differences in asymmetry of cortical surface area, thickness, and local gyrification, and the extent of between-subject variability in these metrics, in a sample of healthy young adults (N = 200). Between-subject variability in cortical structure may provide a means to assess the extent of biological flexibility or constraint of brain regions, and we explored the potential influence of this variability on the phenotypic expression of structural asymmetry. The findings demonstrate that structural asymmetries are nearly ubiquitous across the cortex, with differing regional organization for the three cortical metrics. This implies that there are multiple, only partially overlapping, maps of structural asymmetry. The results further indicate that the degree of asymmetry of a brain region can be predicted by the extent of the region’s between-subject variability. These findings provide evidence that reduced biological constraint promotes the expression of strong structural asymmetry.

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“…In this approach, anatomical labels are assigned by combining local geometric information and atlas data acquired from a manually segmented training set (Desikan et al, 2006;Destrieux, Fischl, Dale, & Halgren, 2010;Fischl et al, 2004). The anterior transverse temporal gyrus (of Heschl) parcellation ("G_temp_sup-G_T_transv") as described in Destrieux et al (2010) (48) Note: Participants were instructed to respond quickly, within a response time limit of 3 s. high interindividual variability and frequent duplications of the transverse temporal gyrus (Leonard et al, 1998;Marie et al, 2015). It thus separates the most anterior gyrus which exclusively contains A1 (Shapleske et al, 1999).…”

Section: Region Of Interest Definitionmentioning

confidence: 99%

Primary auditory cortex representation of fear‐conditioned musical sounds

Staib

Abivardi

Bach

2019

Human Brain Mapping

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Auditory cortex is required for discriminative fear conditioning beyond the classical amygdala microcircuit, but its precise role is unknown. It has previously been suggested that Heschl's gyrus, which includes primary auditory cortex (A1), but also other auditory areas, encodes threat predictions during presentation of conditioned stimuli (CS) consisting of monophones, or frequency sweeps. The latter resemble natural prosody and contain discriminative spectro-temporal information. Here, we use functional magnetic resonance imaging (fMRI) in humans to address CS encoding in A1 for stimuli that contain only spectral but no temporal discriminative information.Two musical chords (complex) or two monophone tones (simple) were presented in a signaled reinforcement context (reinforced CS+ and nonreinforced CS−), or in a different context without reinforcement (neutral sounds, NS1 and NS2), with an incidental sound detection task. CS/US association encoding was quantified by the increased discriminability of BOLD patterns evoked by CS+/CS−, compared to NS pairs with similar physical stimulus differences and task demands. A1 was defined on a single-participant level and based on individual anatomy. We find that in A1, discriminability of CS+/CS− was higher than for NS1/NS2. This representation of unconditioned stimulus (US) prediction was of comparable magnitude for both types of sounds. We did not observe such encoding outside A1. Different from frequency sweeps investigated previously, musical chords did not share representations of US prediction with monophone sounds. To summarize, our findings suggest decodable representation of US predictions in A1, for various types of CS, including musical chords that contain no temporal discriminative information.associative learning, discriminative fear conditioning, emotional learning, multivariate pattern analysis, spectrotemporal information, threat conditioning, threat representation

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Descriptive anatomy of Heschl’s gyri in 430 healthy volunteers, including 198 left-handers

Cited by 105 publications

References 70 publications

Planum temporale asymmetry in developmental dyslexia: Revisiting an old question

Planum temporale asymmetry in developmental dyslexia: Revisiting an old question

Structural asymmetry of the human cerebral cortex: Regional and between-subject variability of surface area, cortical thickness, and local gyrification

Primary auditory cortex representation of fear‐conditioned musical sounds

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