Descriptive analysis of endoscopic findings in patients with a family history of colorectal cancer

Álvarez-Cuenllas, Begoña; Díez-Rodríguez, R.; Vaquero, Luis; Pisabarros, C.; Aparicio, Marta; Rodríguez-Martín, Laura; Muñoz, F.; Olcoz, J.L.; Jorquera, Francisco; Vivas, Santiago

doi:10.1016/j.rgmxen.2015.08.003

Cited by 2 publications

(2 citation statements)

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“…Álvarez-Cuenllas et al suggested that patients with family history might require different strategy of screening CRC because such individuals possessed elevated chances of enduring the same disease. (Álvarez-Cuenllas et al, 2015). They also inferred older age and male gender encompassed greater risk in alignment with other studies (Torre et al, 2015).…”

Section: Discussionsupporting

confidence: 78%

“…According to recent update by World Cancer Research Fund (WCRF)/American Institute of Cancer Research (AICR), alcohol intake increased 10% risk of CRC (Roswall and Weiderpass, 2015). Genetic variation ubiquitously predisposed its deteriorative effect worldwide (Vargas and Thompson, 2012;Bishehsari et al, 2014;Álvarez-Cuenllas et al, 2015;Simons et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Dietary Practices, Addictive Behavior and Bowel Habits and Risk of Early Onset Colorectal Cancer: a Case Control Study

Khan¹,

Hussain²,

Rahman³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The abrupt rise of colorectal cancer in developing countries is raising concern in healthcare settings. Studies on assessing relationships with modifiable and non-modifiable risk factors in the Pakistani population have been limited. The present investigation was designed to examine associations of dietary practices, addictive behavior and bowel habits in developing colorectal cancer (CRC) among patients in a low-resource setup. Materials and Methods: An age-gender matched case control study was conducted from October 2011 to July 2015 in Karachi, Pakistan. Cases were from the surgical oncology department of a public sector tertiary care hospital, while their two pair-matched controls were recruited from the general population. A structured questionnaire was used which included questions related to demographic characteristics, family history, dietary patterns, addictive behavior and bowel habits. Results: A family history of cancer was associated with a 2.2 fold higher chance of developing CRC. Weight loss reduced the likelihood 7.6 times. Refraining from a high fat diet and consuming more vegetables showed protective effects for CRC. The risk of CRC was more than twice among smokers and those who consumed Asian specific addictive products as compared to those who avoid using these addictions (ORsmoking: 2.12, 95% CI: 1.08 -4.17, ORpan: 2.92, 95% CI: 1.6 -5.33, ORgutka: 2.13, 95% CI: 1.14 -3.97). Use of NSAID attenuated risk of CRC up to 86% (OR: 0.14, 95% CI: 0.07 -0.31). Conclusions: Most of the findings showed concordance with the literature elucidating protective effects of consuming vegetables and low fat diet while documenting adverse associations with family history, weight loss, constipation and hematochezia. Moreover, this study highlighted Asian specific indigenous addictive products as important factors. Further studies are needed to validate the findings produced by this research.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%