Descriptive analysis and comparison of two French occupational exposure databases: COLCHIC and SCOLA

Mater, Gautier; Paris, Christophe; Lavoué, Jérôme

doi:10.1002/ajim.22569

Cited by 18 publications

(14 citation statements)

References 27 publications

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“…Companies with a common medical supervision and with available metrological data on the exposure of employees to free silica were selected. For this, the COLCHIC database from the “Institut National de Recherche et Sécurité” (15, 16) and files from the “Caisse d'Assurance Retraite et de la Santé au Travail” and the “Laboratoire Interrégional de Chimie de l'Ouest” were used. Free-silica exposure was ranked as “low,” “moderate” or “high” in respect to CS exposure and according to the metrological data from the COLCHIC database: sampling used an air sampler that captures the respirable (alveolar) fraction of airborne particles (European Standard CN 481).…”

Section: Methodsmentioning

confidence: 99%

T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

et al. 2019

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Background: Chronic silica exposure can lead to silicosis, complicated or not by autoimmune diseases (AID). The pathophysiology of silica-induced AID remains not fully understood, especially immune mechanisms that may develop in patients without yet established silicosis. We conducted a prospective clinical study to analyze the impact of crystalline silica (CS) on T cell phenotype and regulatory T cells (Tregs) frequency, as well as on auto-antibodies development in non-silicotic workers exposed to CS.Methods: Workers with moderate to high exposure level to CS and aged between 30 and 60 years-old were considered for inclusion. Peripheral blood mononuclear cells were analyzed by flow cytometry. Auto-antibodies were screened in serum by immunofluorescence. Blood from 42 and 45 healthy subjects (HC) was used as control for T cell phenotype and serum analyses, respectively.Results: Among the 63 included workers exposed to CS, 55 had full data available and were analyzed. Ten were exposed to CS for <5 years, 18 for 5–10 years and 27 for more than 10 years. The frequency of Tregs (CD4+CD25+CD127−FoxP3+) was significantly lower in CS exposed workers as compared to HC. We found an increased expression of the activation marker HLA-DR on T cells (CD3+, CD4+, and CD8+) of CS exposed workers as compared to HC. Tregs to activated T cells ratio was also lower in exposed subjects. In the latter, HLA-DR expression level and Tregs frequency were significantly associated with CS exposure duration. Serum autoantibody detection was significantly higher in CS exposed workers as compared to HC. Especially, among workers exposed more than 10 years, antinuclear antibodies and ANCA were detected in 44 and 22% among them, as compared to 5 and 2.5% in HC, respectively.Conclusion: This work shows that CS exposure is associated with a decrease of Tregs frequency, an increase of T cell activation status, and a tolerance breakdown against auto-antigens. These results show that alterations of the T cell compartment can be detected early over the course of CS exposure, preceding silicosis development or AID onset.

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Section: Methodsmentioning

confidence: 99%

T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

et al. 2019

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“…A comparison of the French COLCHIC database containing inspection measurements with the SCOLA database containing measurements focused on prevention found that the median concentrations were over three times higher in COLCHIC than in SCOLA; however, the differences were attenuated once sampling duration was taken into account [54]. In contrast, comparisons of the COLCHIC and US OSHA IMIS inspection databases provided similar multi-industry portraits of formaldehyde exposure despite a potential for very different occupational settings [7].…”

Section: Discussionmentioning

confidence: 99%

New Opportunities in Exposure Assessment of Occupational Epidemiology: Use of Measurements to Aid Exposure Reconstruction in Population-Based Studies

Dopart

Friesen

2017

Curr Envir Health Rpt

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Purpose of review Exposure assessment efforts in population-based studies are increasingly incorporating measurements. The published literature was reviewed to identify the measurement sources and the approaches used to incorporate measurements into these efforts. Recent findings The variety of occupations and industries in these studies made collecting participant-specific measurements impractical. Thus, the starting point was often the compilation of large databases of measurements from inspections, published literature, and other exposure surveys. These measurements usually represented multiple occupations, industries, and worksites, and spanned multiple decades. Measurements were used both qualitatively and quantitatively, dependent on the coverage and quality of the data. Increasingly, statistical models were used to derive job-, industry-, time period-, and other determinant-specific exposure concentrations. Summary Quantitative measurement-based approaches are increasingly replacing expert judgment, which facilitates the development of quantitative exposure-response associations. Evaluations of potential biases in these measurement sources, and their representativeness of typical exposure situations, warrant additional examination.

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“…Likewise, all atmospheric concentration measurements conducted by the interregional chemical laboratories of the French regional health insurance funds or by INRS laboratories as part of preventive programmes, prospection, or support for epidemiological studies, are archived in the COLCHIC database [10]. The COLCHIC and SCOLA databases share a common technical structure and comparisons of exposure levels between the two databases are therefore possible [11]. In addition, as the data are derived from different sources, there are no double-entries in the two databases.…”

Section: Methodsmentioning

confidence: 99%

Taking Multiple Exposure Into Account Can Improve Assessment of Chemical Risks

Clerc¹,

Bertrand²,

Rocca³

2017

Annals of Work Exposures and Health

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During work, operators may be exposed to several chemicals simultaneously. Most exposure assessment approaches only determine exposure levels for each substance individually. However, such individual-substance approaches may not correctly estimate the toxicity of 'cocktails' of chemicals, as the toxicity of a cocktail may differ from the toxicity of substances on their own. This study presents an approach that can better take into account multiple exposure when assessing chemical risks. Almost 30000 work situations, monitored between 2005 and 2014 and recorded in two French databases, were analysed using MiXie software. The algorithms employed in MiXie can identify toxicological classes associated with several substances, based on the additivity of the selected effects of each substance. The results of our retrospective analysis show that MiXie was able to identify almost 20% more potentially hazardous situations than identified using a single-substance approach. It therefore appears essential to review the ways in which multiple exposure is taken into account during risk assessment.

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Descriptive analysis and comparison of two French occupational exposure databases: COLCHIC and SCOLA

Abstract: COLCHIC and SCOLA represent a considerable source of information, but result from different purposes (prevention, regulatory). Potential differences due to strategies should evaluated when interpreting data from these databases.

Cited by 18 publications

References 27 publications

T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

New Opportunities in Exposure Assessment of Occupational Epidemiology: Use of Measurements to Aid Exposure Reconstruction in Population-Based Studies

Taking Multiple Exposure Into Account Can Improve Assessment of Chemical Risks

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