Descripción clínica y epidemiológica de pacientes con pancreatitis crónica en un hospital de alta complejidad en Cali, 2011 a 2017

Sepúlveda-Copete, Mauricio; Satizábal-Padridín, Natalia; Hidalgo-Cardona, Alejandra; Criollo-Gutiérrez, Brian D; Tobón-Guevara, Angélica; Llanos, Andres Mauricio Castro; Aguirre-Rojas, Marisol; Rojas-Rodríguez, C.A.

doi:10.22516/25007440.568

Cited by 3 publications

(4 citation statements)

References 50 publications

(96 reference statements)

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“…Chronic pancreatitis is a known risk factor for pancreatic malignancy and is accepted as a premalignant condition [4,29]; however, studies are lacking in this regard [19][20][21]; according to Kirkegård et al there is a 7.9-fold increased risk in the rst two years of follow-up, and through the years, this risk decreases [29]. For that reason, a long-term follow-up for patients with CP con rmed diagnosis is recommended, and in patients in the post-operative period of Frey's procedure [29,30].…”

Section: Discussionmentioning

confidence: 99%

“…It is an uncommon disease with a reported annual incidence of 4-14 cases per 100,000 individuals worldwide [3]. Epidemiological knowledge of CP in Latin America and particularly in Colombia remains scarce [4]. CP's most common clinical feature is epigastric abdominal pain [5], which radiates to the back, relieves when the patient bends forward, and exacerbates after eating [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Outcomes after Frey's procedure for chronic pancreatitis: A 8-year single-center experience in Colombia

González

Ayala

Caballero

et al. 2022

Preprint

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Background Chronic pancreatitis is an inflammatory disease characterized by irreversible morphological changes due to chronic pancreatic fibrosis. The treatment goals are to relieve pain, preserve function, and prevent further pathological consequences. Endoscopic treatment, surgery, or both are options for untreatable pain or suspected malignancy. Frey procedure is a reasonable surgical intervention because of its hybrid character, combining resection and drainage. Unfortunately, there is limited information about the outcomes of this procedure in Latin America, and few cases described in Colombia. This study aims to describe the experience of Colombia's population undergoing Frey's surgery for chronic pancreatitis in a high complexity center experience treating this disease. Methods A retrospective review of a prospectively collected database of patients who underwent a Frey procedure due to chronic pancreatitis between January 2014 to February 2022 in a high complexity center in Bogotá, Colombia, was made. A demographic, clinical and postoperative outcome description was performed. Logistic regression and t-test analysis was performed when appropriate between operative variables and long-term outcomes. Results Eighteen patients met the inclusion criteria. 55.5 % of patients were male. Chronic pancreatitis etiology in most cases (83.3% n=15) was idiopathic. The mean duration of symptoms and chronic pancreatitis diagnosis before surgery was 18.6 ± 26.9 months. Overall morbidity was 38.88%. One patient died at 30 days of follow-up. The median follow-up time was 42.5 (IQR 19;65 months). The mean pain reduction was 3.3 ± 1.02 points according to the visual analog score. Six patients were diagnosed with malignant conditions after surgery (mean 27.8 ± 7.5 months). A protective exposure is present in patients with duct diameter < 6 mm. (OR 0.6 CI 95% 0-0.9).ConclusionAccording to our data, Frey's procedure remains safe and feasible, with acceptable outcomes in terms of pain relief and pancreatic function. The study confirms the importance of a longstanding follow-up due to an inherent risk of pancreatic malignancy. Our data suggest that pancreatic duct size < 6 mm at the moment of the procedure was related to a lesser risk of pancreatic cancer; however, further prospective studies with a larger sample size would be helpful to confirm these results.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Outcomes after Frey's procedure for chronic pancreatitis: A 8-year single-center experience in Colombia

González

Ayala

Caballero

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Chronic pancreatitis is a known risk factor for pancreatic malignancy and is accepted as a premalignant condition [ 4 , 32 ]; however, studies are lacking in this regard [ 19 , 20 , 22 , 25 ]; according to Kirkegård et al there is a 7.9-fold increased risk in the first 2 years of follow-up, and through the years, this risk decreases [ 32 ]. For that reason, a long-term follow-up for patients with CP confirmed diagnosis is recommended, and in patients in the post-operative period of Frey’s procedure [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is an uncommon disease with a reported annual incidence of 4–14 cases per 100,000 individuals worldwide [ 3 ]. Epidemiological knowledge of CP in Latin America and particularly in Colombia remains scarce [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Outcomes after Frey’s procedure for chronic pancreatitis: a 8-year single-center experience in Colombia

et al. 2022

View full text Add to dashboard Cite

Background Chronic pancreatitis is an inflammatory disease characterized by irreversible morphological changes due to chronic pancreatic fibrosis. The treatment goals are to relieve pain, preserve function, and prevent further pathological consequences. Endoscopic treatment, surgery, or both are options for untreatable pain or suspected malignancy. Frey procedure is a reasonable surgical intervention because of its hybrid character, combining resection and drainage. Unfortunately, there is limited information about the outcomes of this procedure in Latin America, and few cases described in Colombia. This study aims to describe the experience of a pancreatic surgery reference center in the management of patients undergoing Frey’s surgery for chronic pancreatitis. Methods A retrospective review of a prospectively collected database of patients who underwent a Frey procedure due to chronic pancreatitis between January 2014 to February 2022 in a hospital in Bogotá, Colombia, was made. A demographic, clinical, and postoperative outcome description was performed. Mann–Whitney Willcoxon test was performed between operative variables and long-term outcomes. Results Eighteen patients met the inclusion criteria. 55.5% of patients were male. Chronic pancreatitis etiology in most cases (83.3% n = 15) was idiopathic. The median duration of symptoms and chronic pancreatitis diagnosis before surgery was 6.15 months (IQR 5;97). Overall morbidity was 38.88%. One patient died at 30 days of follow-up. The median follow-up time was 42.5 (IQR 19;65 months). The median pain reduction was 3 points according to the visual analog score. Six patients were diagnosed with malignant conditions after surgery (mean 27.8 ± 7.5 months). Wirsung’s duct size was statistically related with malignancy presentation after Frey’s procedure (Z = 2.54; P = 0.01). Conclusion According to our data, Frey’s procedure remains safe and feasible, with acceptable outcomes in terms of pain relief and pancreatic function. The study confirms the importance of a longstanding follow-up due to an inherent risk of pancreatic malignancy. Our data suggest that pancreatic duct size could be related with the malignancy diagnosis after Frey’s procedure; however, further prospective studies with a larger sample size would be helpful to confirm these results.

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Preliminary Investigation of Normal Pancreas Elasticity using Point Shear Wave Elastography

Almutairi

2023

CMIR

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Background Point shear wave elastography (pSWE) is used to provide quantitative information about the elasticity of the tissues. It has been used in many clinical applications to identify diseases early. This study aims to assess the suitability of pSWE to evaluate pancreas tissue stiffness and provide normal reference values for healthy pancreas tissues. Methods This study was conducted in the diagnostic department at a tertiary care hospital between October and December 2021. Sixteen healthy volunteers (eight men and eight women) participated. Pancreas elasticity measurements were obtained in different regions of interest (head, body, and tail). Scanning was performed by a certified sonographer using Philips EPIC7 ultrasound systems (Philips Ultrasound; Bothel, WA, USA). Results The mean velocity of the head of the pancreas was 1.3 ± 0.3 m/s (median: 1.2 m/s), the body was 1.4 ± 0.3 m/s (median: 1.4 m/s), and the tail was 1.4 ± 0.4 m/s (median: 1.2 m/s). The mean dimension was 17 ±3 mm, 14 ±4 mm, and 14 ±6 mm for the head, body, and tail. The correlation of pancreas velocity across different segments and dimensions shows no significant difference with p values of 0.39 and 0.11, respectively. Conclusion This study shows that assessing the elasticity of the pancreas using pSWE is possible. A combination of SWVs measurements and dimensions could provide an early evaluation of pancreas status. Further studies including pancreatic disease patients are recommended.

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Descripción clínica y epidemiológica de pacientes con pancreatitis crónica en un hospital de alta complejidad en Cali, 2011 a 2017

Cited by 3 publications

References 50 publications

Outcomes after Frey's procedure for chronic pancreatitis: A 8-year single-center experience in Colombia

Outcomes after Frey's procedure for chronic pancreatitis: A 8-year single-center experience in Colombia

Outcomes after Frey’s procedure for chronic pancreatitis: a 8-year single-center experience in Colombia

Preliminary Investigation of Normal Pancreas Elasticity using Point Shear Wave Elastography

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