Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats

Rossaneis, Ana C.; Genaro, Karina; Dias, Quintino Moura; Guethe, L. M.; Fais, Rafael Sobrano; Bel, Elaine Aparecida Del; Prado, Wiliam A.

doi:10.1002/ejp.638

Cited by 8 publications

(14 citation statements)

References 29 publications

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“…Although different, these intervals are all within the minimum of 2 days reported above as adequate to produce an irreversible neurotoxic effect . In addition, these results are similar to those recently shown in identical model following injection of lidocaine or NMDA into the entire APtN . Therefore, the difference in the WT among NMDA‐ and PBS‐treated rats present 4 days after the injection but absent 5 days later is unlikely to result from different intervals for the neurotoxic effect of NMDA.…”

Section: Discussionsupporting

confidence: 88%

“…The APtN exerts a tonic inhibitory influence against experimental neuropathic pain . In addition, we showed here that the vAPtN, but not the dAPtN controls mechanisms that initiate but do not maintain neuropathic pain.…”

Section: Discussionmentioning

confidence: 54%

“…The APtN stimulation activates non‐serotonergic descending mechanisms that excite nociceptive‐specific neurons in the superficial laminae and inhibit multireceptive neurons in lamina V in the spinal dorsal horn . More recently it was shown that the APtN is involved in the initial, but not maintenance phase of the tactile hypersensitivity following ligature of the sciatic nerve …”

Section: Discussionmentioning

confidence: 99%

“…The dorsal roots sectioning‐induced autotomy behaviour in rats occurred earlier and to a greater extent in rats with an APtN lesion . In addition, APtN cells control mechanisms that initiate, but not those that maintain, neuropathic pain …”

Section: Introductionmentioning

confidence: 98%

“…12 In addition, APtN cells control mechanisms that initiate, but not those that maintain, neuropathic pain. 13 The present study examines whether injection of N-methyl-Daspartate (NMDA) into the dAPtN or vAPtN changes the withdrawal threshold (WT) to mechanical stimulation of a rat hind paw in different phases of the tactile hypersensitivity induced by a chronic constriction injury (CCI) of the sciatic nerve. The number of Fos-immunoreactive (Fos-ir) neurons in dAPtN or vAPtN during the same phases was evaluated also.…”

Section: Introductionmentioning

confidence: 99%

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The ventral portion of the anterior pretectal nucleus controls descending mechanisms that initiate neuropathic pain in rats

Rossaneis

Prado

2015

Clin Exp Pharma Physio

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Stimulating the dorsal anterior pretectal nucleus (dAPtN) in rats is more effective than stimulating the ventral APtN (vAPtN) at reducing tail-flick latency, whereas stimulation of the vAPtN is more effective at reducing postoperative pain behaviour. This study examines whether a cell lesion caused by injecting N-methyl-D-aspartate into the dAPtN or vAPtN changes the withdrawal threshold of a rat hind paw during different phases of the tactile hypersensitivity induced by a chronic constriction injury (CCI) of the contralateral sciatic nerve. The number of Fos immunoreactive cells in the APtN was also evaluated. The rats whose vAPtN was lesioned 2 days before CCI had more intense tactile hypersensitivity 2 days after CCI than that of the control group, but the groups were not different 7 days after the CCI. The rats whose vAPtN was lesioned 5 days after CCI had withdrawal thresholds that did not differ significantly 7 days after the CCI. The tactile hypersensitivity of the rats whose dAPtN was lesioned 2 days before or 5 days after CCI was not different from that of the control on the second and seventh days after the CCI. The number of Fos immunoreactive cells in the vAPtN and dAPtN increased 2 days after CCI, but did not differ from that in the control 7 days after CCI. We conclude that vAPtN and dAPtN cells are activated by nerve injury; the vAPtN exerts inhibitory control of the initial phase of neuropathic pain whereas the dAPtN does not appear to exert an inhibitory effect in neuropathic processing.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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