Descemet Membrane Endothelial Keratoplasty Postoperative Year 1 Endothelial Cell Counts

Gorovoy, Ian R.; Gorovoy, Mark S.

doi:10.1016/j.ajo.2014.12.008

Cited by 37 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding the ECD loss, our results are consistent with data in the literature; the one‐year ECD loss rate varies between 19% and 40% (Quilendrino et al. ; Gorovoy & Gorovoy ; Reid et al. ).…”

Section: Discussionsupporting

confidence: 91%

“…Endothelial cell loss occurs during different phases of DMEK surgery: corneal harvesting, graft preparation, intraoperative manipulation and during the “natural” course of postoperative endothelial cell dropout (Gorovoy & Gorovoy ; Parekh et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…Endothelial cell loss occurs during different phases of DMEK surgery: corneal harvesting, graft preparation, intraoperative manipulation and during the "natural" course of postoperative endothelial cell dropout (Gorovoy & Gorovoy 2015;Parekh et al 2017). Furthermore, endothelial cell loss occurs also in immunological rejection episodes and after rebubbling.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of donor tissue diameter on postoperative central endothelial cell density in Descemet Membrane Endothelial Keratoplasty

Schrittenlocher

Bachmann

Cursiefen

2018

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose To assess the effect of donor tissue diameter in Descemet Membrane Endothelial Keratoplasty (DMEK) on postoperative endothelial cell density (ECD) mainly in Fuchs Endothelial Corneal Dystrophy (FECD) patients. Methods Retrospective review of 693 consecutive DMEK surgeries from the prospective Cologne DMEK database performed between 07/2011 and 07/2016 at the Department of Ophthalmology, University of Cologne. Eight‐ versus ten‐millimetre large donor DMEK grafts of two different surgeons using identical surgical techniques were compared. Results A total of 693 consecutive DMEK surgeries were included. Two groups (8 versus 10 mm DMEK graft diameter) were compared: 23% of eyes received 8‐mm grafts (group 1, n = 160) and 77% 10‐mm grafts (group 2, n = 533). Mean preoperative ECD (±SD) of donor tissue was 2736 ± 224 cells/mm2 in group 1 and 2714 ± 232 in group 2. Group 1 showed a mean ECD of 1740 ± 439 cells/mm2 (mean ± SD; n = 67) 12 months after DMEK compared to 1664 ± 404 cells/mm2 (mean ± SD; n = 344) in group 2. The difference between the 6‐ and 12‐month ECD of both groups was not significant (p = 0.675; p = 0.161). Total decrease in ECD 6‐ and 12‐months postoperatively was 38 ± 14 (n = 128) and 36 ± 16% in group 1 (n = 66) versus 37 ± 15% (n = 398) and 38 ± 15% in group 2 (n = 342; p = 0.414; p = 0.198, respectively). Conclusion Our data suggest that postoperative central endothelial cell density is not significantly associated with DMEK graft diameters in the range of 8–10 mm in cases with healthy peripheral host endothelium (such as FECD).

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of donor tissue diameter on postoperative central endothelial cell density in Descemet Membrane Endothelial Keratoplasty

Schrittenlocher

Bachmann

Cursiefen

2018

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…Longer term studies with a variable follow-up rate report EC loss of around 19–36% at 1 year 20 61 78 79. The longest term results report a median 5-year cell loss of 39% in DMEK (28 eyes), which compared favourably with prior reports of DSEK (53%) and PKP (70%) performed for similar indications 61.…”

Section: Outcomes: Visual Acuity and Ec Lossmentioning

confidence: 62%