Deromanticizing medical assistance in dying

Gallagher, Romayne; Passmore, Michael J.

doi:10.1503/cmaj.78845

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…The hereditary risk of prostate cancer contributes significantly to tumor development. It is believed that around 20% of individuals with prostate cancer have a family history of the disease, which may arise not only from shared genes but also from a similar pattern of exposure to specific environmental carcinogens and related lifestyle choices [9,10]. Several studies have found that inherited genetic background is linked to an elevated risk of prostate cancer, accounting for roughly 5% of disease risks [11,12].…”

Section: Introductionmentioning

confidence: 99%

Identification of Genetic Alterations in Prostate Cancer Using Gene Expression Profiling

Kucukakcali,

Cicek

2023

Cancer Sci Re

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Aim: In this study, an open-access dataset of mRNAs from primary prostate cancer samples and matched normal tissue samples was used to identify genetic alterations that play a role in the development of prostate cancer, the most common malignant tumor in men with increasing incidence. Material and Methods: The dataset used in the study consists of 10 primary prostate cancer samples and a sample of normal tissue. 20024 genes were sequenced from these tissues. Gene expression analysis was performed with the data set using the limma package in the R programming language. Enrichment analysis was performed with the clusterProfiler package. Results: 1028 of 20024 genes showed different up- or down-regulation in primary prostate cancer tissues compared to normal tissues. According to the results of the enrichment analysis with these genes, the processes that play a role in primary prostate cancer are protein binding, binding, cellular process, biological process, and response to stimulus. Conclusion: As a result, it can be said that the genetic structure of primary prostate cancer tissues changes compared to normal tissues, with the information obtained from gene expression analysis and enrichment analysis. It can be said that it is possible to increase the therapeutic effectiveness of the disease by analyzing the biomarkers with comprehensive and various methods.

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Section: Introductionmentioning

confidence: 99%

Identification of Genetic Alterations in Prostate Cancer Using Gene Expression Profiling

Kucukakcali,

Cicek

2023

Cancer Sci Re

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Canada’s Medical Assistance in Dying System can Enable Healthcare Serial Killing

Lyon

2024

HEC Forum

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The Canadian approach to assisted dying, Medical Assistance in Dying (MAiD), as of early 2024, is assessed for its ability to protect patients from criminal healthcare serial killing (HSK) to evaluate the strength of its safeguards. MAiD occurs through euthanasia or self-administered assisted suicide (EAS) and is legal or considered in many countries and jurisdictions. Clinicians involved in HSK typically target patients with the same clinical features as MAiD-eligible patients. They may draw on similar rationales, e.g., to end perceived patient suffering and provide pleasure for the clinician. HSK can remain undetected or unconfirmed for considerable periods owing to a lack of staff background checks, poor surveillance and oversight, and a failure by authorities to act on concerns from colleagues, patients, or witnesses. The Canadian MAiD system, effectively euthanasia-based, has similar features with added opportunities for killing afforded by clinicians’ exemption from criminal culpability for homicide and assisted suicide offences amid broad patient eligibility criteria. An assessment of the Canadian model offers insights for enhancing safeguards and detecting abuses in there and other jurisdictions with or considering legal EAS. Short of an unlikely recriminalization of EAS, better clinical safeguarding measures, standards, vetting and training of those involved in MAiD, and a radical restructuring of its oversight and delivery can help mitigate the possibility of abuses in a system mandated to accommodate homicidal clinicians.

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Quebec population highly supportive of extending Medical Aid in Dying to incapacitated persons and people suffering only from a mental illness: Content analysis of attitudes and representations

Plaisance

Mishara

Masella

et al. 2022

Ethics, Medicine and Public Health

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Deromanticizing medical assistance in dying

Cited by 4 publications

References 4 publications

Identification of Genetic Alterations in Prostate Cancer Using Gene Expression Profiling

Identification of Genetic Alterations in Prostate Cancer Using Gene Expression Profiling

Canada’s Medical Assistance in Dying System can Enable Healthcare Serial Killing

Quebec population highly supportive of extending Medical Aid in Dying to incapacitated persons and people suffering only from a mental illness: Content analysis of attitudes and representations

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