Dermoscopy of Facial Angiofibromas in Four Patients of Skin of Color with Tuberous Sclerosis Complex: A Case-Series

Jindal, Rashmi; Sethi, Sheenam; Chauhan, Payal

doi:10.5826/dpc.1103a36

Cited by 5 publications

(5 citation statements)

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“…To date, the dermoscopy findings of FAs associated to TSC, consisting of a reddish‐brown background, whitish globules, comma and/or hairpin vessels, gray‐brown dots and crypts, have been described only in patients with skin of color. 7 , 8 , 9 In our cases, we observed in all lesions the same dermoscopic features except for gray‐brown dots and crypts observed in the previous reports, probably related to the different phototype. Regarding the histopathological correlation, the whitish globules likely correspond to perifollicular fibrosis, and the reddish‐brown background to increased number of dermal vessels and melanocytic hyperplasia.…”

Section: Figuresupporting

confidence: 87%

“…Regarding the histopathological correlation, the whitish globules likely correspond to perifollicular fibrosis, and the reddish-brown background to increased number of dermal vessels and melanocytic hyperplasia. [7][8][9][10] In conclusion, we described for the first time the dermoscopic aspects of FAs in patients with skin phototype II-III affected by TSC.…”

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confidence: 72%

“…Regarding the histopathological correlation, the whitish globules likely correspond to perifollicular fibrosis, and the reddish‐brown background to increased number of dermal vessels and melanocytic hyperplasia. 7 , 8 , 9 , 10 …”

Section: Figurementioning

confidence: 99%

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Dermoscopy of facial angiofibromas in Fitzpatrick II‐III phototype subjects affected by tuberous sclerosis complex

Lacarrubba,

Verzì,

Magnani

et al. 2023

Skin Research and Technology

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Tuberous Sclerosis Complex (TSC) is an autosomal dominant multisystemic syndrome with a wide range of clinical features. [1][2][3] The diagnosis is generally easy and is usually based on the recognition during infancy of typical cutaneous and neurologic signs. However, skin lesions may show different age of onset and severity making the diagnosis more difficult. [1][2][3] In case of mild disease, TSC may remain unknown for years.Facial angiofibromas (FAs) are benign hamartomatous skin growths occurring in nearly 75% of patients with TSC. 4,5 They appear as reddish, fibrous, dome-shaped papules mainly involving the central area of the face (especially around nasolabial folds). The usual onset is between ages 2 and 5 years. 2,4 The identification of FAs is important as they may represent the sign of a TSC not yet diagnosed. Although one or two isolated sporadic lesions may be observed within the general population, F I G U R E 1 (A-D) Facial angiofibromas in four children affected by tuberous sclerosis complex: reddish, dome-shaped papules mainly involving the central area of the face.

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Section: Figuresupporting

confidence: 87%

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confidence: 72%

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Dermoscopy of facial angiofibromas in Fitzpatrick II‐III phototype subjects affected by tuberous sclerosis complex

Lacarrubba,

Verzì,

Magnani

et al. 2023

Skin Research and Technology

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“…A total of nine instances from three analyses (two case series and a single report) were assessed by dermoscopy [ 15 , 21 , 22 ]. The most common feature reported by all the studies included white/yellow-white dots [ 15 , 21 , 22 ]; other frequent findings were, brown/reddish-brown background, unfocused vessels, and brown dots [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Dermoscopy of Cutaneous Neoplasms in Skin of Color – A Systematic Review by the International Dermoscopy Society “Imaging in Skin of Color” Task Force

Enechukwu,

Behera,

Ding

et al. 2023

Dermatol Pract Concept

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Over the last few decades, dermoscopy has been showed to facilitate the non-invasive diagnosis of both benign and malignant skin tumors, yet literature data mainly comes from studies on light phototypes. However, there is growing evidence that skin neoplasms may benefit from dermoscopic assessment even for skin of color. This systematic literature review evaluated published data in dark-skinned patients (dermoscopic features, used setting, pathological correlation, and level of evidence of studies), also providing a standardized and homogeneous terminology for reported dermoscopic findings. A total of 20 articles describing 46 different tumors (four melanocytic neoplasms, eight keratinocytic tumors, 15 adnexal cutaneous neoplasms, seven vascular tumors, four connective tissue tumors, and eight cystic neoplasms/others) for a total of 1724 instances were included in the analysis. Most of them showed a level of evidence of V (12 single case reports and six case series), with only two studies featuring a level of evidence of IV (case-control analysis). Additionally, this review also underlined that some neoplasms and phototypes are underrepresented in published analyses as they included only small samples and mainly certain tones of “dark skin” spectrum (especially phototype IV). Therefore, further studies considering such limitations are required for a better characterization.

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“…The dermoscopic features are commonly present as multiple yellow-white dots over a pinkish-gray or reddish-brown background, and brown pigmentation dots and surface crypts are seen in partial angiofibromas. [ 2 3 ] Multiple yellow-white globules represent histopathologic follicular hyperkeratosis; brown pigment dots correspond to dermal melanophages; surface crypts represent pseudo-follicular openings; pinkish-gray or reddish-brown background associates with melanocytic hyperplasia and proliferating dermal blood vessels. [ 2 3 ] In our patient, the dermoscopic presentation of clustered, smooth, reddish-brown, hemispheric structures is newly described.…”

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confidence: 99%

New Dermoscopic Findings in the Facial Angiofibromas of Tuberous Sclerosis Complex

Zhang,

Wu,

2023

Indian Journal of Dermatology

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Dermoscopy of Facial Angiofibromas in Four Patients of Skin of Color with Tuberous Sclerosis Complex: A Case-Series

Cited by 5 publications

References 4 publications

Dermoscopy of facial angiofibromas in Fitzpatrick II‐III phototype subjects affected by tuberous sclerosis complex

Dermoscopy of facial angiofibromas in Fitzpatrick II‐III phototype subjects affected by tuberous sclerosis complex

Dermoscopy of Cutaneous Neoplasms in Skin of Color – A Systematic Review by the International Dermoscopy Society “Imaging in Skin of Color” Task Force

New Dermoscopic Findings in the Facial Angiofibromas of Tuberous Sclerosis Complex

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