Dermoscopy: a useful auxiliary tool in the diagnosis of type 1 segmental Darier’s disease

Abstract

Type 1 segmental Darier’s disease is a blaschkolinear variant of Darier’s disease resulting from a postzygotic mosaicism. Since it usually lacks diagnostic clues typical of the generalized form, including positive family history of the disease, nail and mucosal abnormalities, and/or acral involvement, its distinction from other acquired inflammatory blaschkolinear dermatoses may often be quite challenging, thus requiring histopathological examination to reach a definitive diagnosis. We report a case of type 1 segmental Darier’s disease with its dermoscopic findings in order to show the usefulness of dermoscopy in assisting the noninvasive identification of this condition.

Dermoscopic clues of palmoplantar hyperkeratotic eczema and palmoplantar psoriasis: A prospective, comparative study of 90 patients

“…Vascular distribution pattern is one of the properties that may be useful in the differential diagnosis of eczema and psoriasis in addition to vascular morphology. Dermoscopy of plaque psoriasis typically shows a characteristic pattern consisting of diffuse white scales and symmetrically and regularly distributed dotted vessels on a light or dull red background 8,13–16,19,22–29 . Lallas et al 14 .…”

Onychoscopy

“…Nail lichen planus • Chromonychia, nail fragmentation, splinter hemorrhages, onycholysis, subungual keratosis, and longitudinal streaks (Nakamura et al 2013) is an important disease to be differentiated from Darier's disease. Although both conditions show absent lunula, the alternating red and white bands on the nail plate are characteristic patterns in Darier's disease (Errichetti et al 2016).…”

“…Darier's Disease seborrheic areas such as scalp, face, and trunk. Characteristic nail changes include red or white longitudinal bands often ending in a pathognomonic notch at the free margin of the nail (Errichetti et al 2016) (Fig. 60).…”

“…• Prognosis and treatment: Topical corticosteroids and emollients are the mainstay of treatment. Generally, it has a good prognosis (Errichetti et al 2016). • Differential diagnosis: Nail lichen planus.…”

“…Definition: Darier's disease is a rare autosomal dominant genodermatosis characterized by suprabasilar acantholytic dyskeratosis. Red and white bands in an alternating fashion are the characteristic in onychoscopy of this disease(Errichetti et al 2016).• Clinical feature: The distinctive lesions are skin-colored, yellow-brown, or brown firm rough papules in the…”