Dermoscopic variability of basal cell carcinoma according to clinical type and anatomic location

Suppa, Mariano; Micantonio, Tamara; Stefani, Alessandro; Soyer, H. Peter; Chimenti, Sergio; Fargnoli, Maria Concetta; Peris, Ketty

doi:10.1111/jdv.12980

Cited by 54 publications

(70 citation statements)

References 51 publications

(120 reference statements)

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“…However, this number is likely to be underestimated because of the exclusion of many clinical and dermoscopic clear-cut superficial BCCs in which surgical excision/biopsy was not performed, due to them be- ing treated with topical and physical methods. Interestingly, only a minority of BCCs were clinically pigmented in our study sample, which is in accordance with previous reports showing that pigmented BCCs are mostly located on the trunk [11]. Furthermore, even though dermoscopy is known to increase the number of pigmented BCCs by detecting clinically undetectable pigmented criteria, only few of our lesions displayed those criteria, which were mostly classified as melanoma-looking lesions [17,18].…”

Section: Discussionsupporting

confidence: 79%

“…Contrasting data are reported according to the distribution by sex of patients with BCCs on lower limbs. In our study, the vast majority of patients enrolled were males (51/81 cases), which is in contrast with a previous report of 150 cases, in which females were predominant [15], but in agreement with further studies [10,11]. Our results also showed that the vast majority of BCCs of the lower extremities were superficial in histologic subtype, according to previous studies [10,16].…”

Section: Discussioncontrasting

confidence: 57%

“…In the literature, few studies have focused on the dermoscopicspecific aspect of BCCs located on the lower limbs. Pranteda et al [10] and Suppa et al [11] reported a prevalence of 7.0 and 7.9%, respectively, while, Wolner et al [12] found a higher (13.8%) prevalence. Contrasting data are reported according to the distribution by sex of patients with BCCs on lower limbs.…”

Section: Discussionmentioning

confidence: 96%

“…Wolner et al [12] recently found a higher frequency of polymorphous and thin serpentine vessels in BCCs of the lower extremities, which instead demonstrated the lower prevalence of arborizing vessels, compared to other anatomic sites. Suppa et al [11] investigated the distribution of dermoscopic BCC criteria according to the body site and showed that short fine telangiectasia, spoke wheel areas, and small erosions were independently associated with trunk location, arborizing telangiectasia with face location, and glomerular and polymorphous vessels with location on the legs.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, dermoscopy has also been proven to be useful in BCC subtype prediction, presurgical margin definition, and posttreatment assessment [7][8][9]. To date, only few reports have focused on dermoscopic features of BCC according to body site; in particular, there is a lack of data on BCC located on the lower limbs [10][11][12]. The aim of this retrospective study was to describe the dermoscopic features of BCC of the lower limbs, testing the hypothesis that this tumor frequently simulates other malignant or benign lesions.…”

Section: Introductionmentioning

confidence: 99%

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Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

et al. 2017

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Background:Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions. Objective: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benignor malignant-looking appearance. Methods: We conducted a retrospective study enrolling consecutive patients with histologically confirmed BCCs of the lower limbs. Lesions were classified in 7 categories according to the clinical and dermoscopic global appearance. Clear BCC, squamous cell carcinoma (SCC) or Bowen disease-like, Kaposi disease-like, melanoma-like, and aspecific pattern were considered malignant-looking lesions; however, seborrheic keratosis-like and dermatofibroma-like were considered benign-looking. To define which dermoscopic criteria were independently associated with benign-or malignant-looking appearance, we conducted a multivariate logistic regression analysis. Results:A total of 81 BCCs were enrolled: 18 (22%) were benign-looking lesions (of which 11 were seborrheic keratosis-like and 7 dermatofibroma-like) and 63 (78%) were malignant-looking BCCs (of which 24 were clear-cut BCCs, 23 SCC-like, 2 Kaposi disease-like, 9 melanoma-like, and 5 had aspecific pattern). Multivariate regression analysis showed that erosions/ulceration and vessels were independently associated with malignant-looking appearance. The most represented vessels were glomerular and polymorphic, which are more frequently encountered in SCC, together with ulceration. Conclusion: BCC of the lower legs frequently simulates other benign or malignant lesions, with SCC being the main differential diagnosis.

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Section: Discussionsupporting

confidence: 79%

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

et al. 2017

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Clinical and dermoscopic variation of basal cell carcinoma according to age of onset and anatomic location: a multicenter, retrospective study

et al. 2023

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Characteristics of Giant Nodular Melanomas in Special Locations: a Case Series and Review of the Literature

Kamińska‐Winciorek

Galwas

Suchorzepka

et al. 2022

Dermatol Ther (Heidelb)

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Introduction Nodular melanoma (NM) is a rare subtype of melanoma, responsible for more than 40% of melanoma deaths, characterized by rapid growth and high metastatic potential. Only a few case studies concerning the dermoscopic presentations of giant nodular melanoma have been reported so far. Objectives The aim of the study was to assess dermoscopic features of giant nodular melanomas in special locations, along with their clinical and histopathologic aspects. Methods Among 120 patients with histopathologically confirmed melanoma treated by the Skin Cancer and Melanoma Team between September 2020 and February 2021, we identified six patients with giant nodular melanoma in special locations. We retrospectively assessed the archived dermoscopic images to determine the dermoscopic features of these tumors. Results The group consisted of six cases of giant melanoma in special locations, including the scalp (4/6) and the heel (2/6). The giant tumors were large in size (at least 5 cm in diameter). The most common dermoscopic structures in polarized light included asymmetric distribution of dermoscopic structures, the presence of structureless, multicolored zones (showing three or more colors), and the presence of white perpendicular lines or small, pink globules. Conclusions It seems that there are no significant differences in dermoscopy between small and giant melanomas; however, further studies should be conducted on a larger scale.

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Dermoscopic variability of basal cell carcinoma according to clinical type and anatomic location

Cited by 54 publications

References 51 publications

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

Clinical and dermoscopic variation of basal cell carcinoma according to age of onset and anatomic location: a multicenter, retrospective study

Characteristics of Giant Nodular Melanomas in Special Locations: a Case Series and Review of the Literature

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