Dermoscopic predictors to discriminate between in situ and early invasive lentigo maligna melanoma: A retrospective observational study

Peruilh-Bagolini, Leonardo; Apalla, Zoe; González‐Cuevas, Rubén; Lallas, Konstantinos; Papageorgiou, Chryssoula; Bobos, Mattheos; Manoli, Sofia Magdalini; Gkentsidi, Theodosia; Spyridis, Ioannis; Lazaridou, Elizabeth; Sotiriou, Elena; Vakirlis, Efstratios; Ioannides, Dimitrios; Lallas, Aimilios

doi:10.1016/j.jaad.2020.03.030

Cited by 10 publications

(19 citation statements)

References 5 publications

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“…At the start of the procedure, the lesion was marked with a margin of 3 mm, marking stiches were placed and the lesion was excised under local anaesthesia. Prior to the procedure, the research physician and the dermatologist with oncologic experience used dermoscopy to mark 0–5 spots within the LM that were suspect for invasive growth using this criteria: homogenous areas, irregular blotches, black colour, obliterated hair follicles and milky red areas 7–9 . In the absence of suspect spots no needle was placed.…”

Section: Methodsmentioning

confidence: 99%

“…6 Dermoscopy may help differentiating between LM, LMM, other types of melanoma and solar lentigo. [7][8][9] Complete surgical (staged) excision is the best treatment of clinical and biopsy-proven LM 10 as it enables histological examination of the lesion. It allows differentiating between LM and LMM 11 and assesses whether the margins are free of lentigo maligna (melanoma).…”

Section: Introductionmentioning

confidence: 99%

“…The presentation of LM and LMM may be subtle and a diagnostic delay is common 6 . Dermoscopy may help differentiating between LM, LMM, other types of melanoma and solar lentigo 7–9 …”

Section: Introductionmentioning

confidence: 99%

“…It has therefore been advocated that dermatologists should indicate areas suspicious for invasive growth within a LM lesion for guided histological examination to increase the likelihood of LMM diagnosis. The following dermoscopic criteria are clues for LMM: homogenous areas, irregular blotches, black colour, obliterated hair follicles and milky red areas 7–9 . To our knowledge studies investigating this clinically guided investigation of LM lesions are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Clinical findings are not helpful in detecting lentigo maligna melanoma in patients with biopsy‐proven lentigo maligna

Zoutendijk

Koljenović

Wakkee

et al. 2022

Acad Dermatol Venereol

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Background Lentigo maligna (LM) based on biopsy material might be lentigo maligna melanoma (LMM) after excision.Objectives Investigate whether clinical and dermoscopic mapping increases the detection rate of LMM when investigating staged excision specimens of biopsy proven LM.Methods Patients with biopsy-proven LM planned for staged excision were included. Using clinical inspection and dermoscopy, spots suspicious for LMM were marked. After the excision, needles were placed at the marked spots. Histological examination using vertical sections was done at the needles followed by the standard amount of vertical sections. ResultsIn 28 of the 58 biopsy-proven LM, there was clinical suspicion of LMM, only 3 of these 28 cases were upgraded into LMM. These three cases showed LMM in other sections, whereas only 1 case showed LMM around the needle. Within the group without clinical suspicion of LMM, 2 cases were LMM. Biopsy-proven LM were in fact LMM in 8.6% of the cases and were found without the clinical guidance of the dermatologist.Conclusions 8.6% of the biopsy-proven LM were LMM after complete histological examination. In this study, the dermatologist was not able to increase the detection rate of LMM by using clinical and dermoscopic mapping.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The presentation of LM and LMM may be subtle and a diagnostic delay is common 6 . Dermoscopy may help differentiating between LM, LMM, other types of melanoma and solar lentigo 7–9 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical findings are not helpful in detecting lentigo maligna melanoma in patients with biopsy‐proven lentigo maligna

Zoutendijk

Koljenović

Wakkee

et al. 2022

Acad Dermatol Venereol

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“…Recently, Peruilh-Bagolini et al confirmed that gray circles/semicircles and angulated lines are negative predictors of invasive LM while obliterated follicles, irregular blotches, and black color positively predicted invasive LM. These findings are important when incisional biopsies on LM are performed: selecting the area to biopsy with dermoscopy allows to not underestimate the invasive component [86].…”

Section: Melanoma Occurring On Non-facial Chronically Sun Exposed Skinmentioning

confidence: 98%

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin

Massone

Hofman-Wellenhof

Chiodi

et al. 2021

Genes

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Dermoscopy is a non-invasive, in vivo technique that allows the visualization of subsurface skin structures in the epidermis, at the dermoepidermal junction, and in the upper dermis. Dermoscopy brought a new dimension in evaluating melanocytic skin neoplasms (MSN) also representing a link between clinical and pathologic examination of any MSN. However, histopathology remains the gold standard in diagnosing MSN. Dermoscopic–pathologic correlation enhances the level of quality of MSN diagnosis and increases the level of confidence of pathologists. Melanoma is one of the most genetically predisposed among all cancers in humans. The genetic landscape of melanoma has been described in the last years but is still a field in continuous evolution. Melanoma genetic markers play a role not only in melanoma susceptibility, initiation, and progression but also in prognosis and therapeutic decisions. Several studies described the dermoscopic specific criteria and predictors for melanoma and their histopathologic correlates, but only a few studies investigated the correlation among dermoscopy, pathology, and genetic of MSN. The aim of this work is to review the published data about dermoscopic features of melanoma, their histopathological correlates with regards also to genetic alterations. Particularly, this review will focus on low-CSD (cumulative sun damage) melanoma or superficial spreading melanoma, high-CSD melanoma, and nevus-associated melanoma.

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El lentigo maligno: actualización y claves en el diagnóstico y el tratamiento

Requena¹,

Manrique²,

Nagore³

2023

Actas Dermo-Sifiliográficas

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Dermoscopic predictors to discriminate between in situ and early invasive lentigo maligna melanoma: A retrospective observational study

Abstract: Funding sources: None. Conflicts of interest: None disclosed.IRB approval status: This project was a quality improvement initiative and thus was not formally supervised by our IRB per their policies.

Cited by 10 publications

References 5 publications

Clinical findings are not helpful in detecting lentigo maligna melanoma in patients with biopsy‐proven lentigo maligna

Clinical findings are not helpful in detecting lentigo maligna melanoma in patients with biopsy‐proven lentigo maligna

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin

El lentigo maligno: actualización y claves en el diagnóstico y el tratamiento

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