Dermoscopic phenotype of pseudoxanthoma elasticum skin lesions: a study of 16 patients

Berthin, C.; Phan, Alice; Navasiolava, Nastassia; Michalak, Sophie; Humeau, H.; Grimaux, Xavier; Martin, Ludovic

doi:10.1111/jdv.15534

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Altogether, 105 images were analyzed. Using the AF images, the PXE-affected areas were selected manually as regions of interest (ROI) based on their DS morphology according to patterns described earlier [15,17]. Adjacent to the affected areas, the uninvolved background skin served as the control group.…”

Section: Autofluorescence and Diffuse Reflectance Imaging With Narrowmentioning

confidence: 99%

“…The pattern of globules can present as dots, irregular broad or narrow mesh networks or parallel lines that coalesces to plaques. The vascular pattern appears as a fine reticular network or a pink background [15]. A previous study assumed that the dermal elastolysis results in the vascular realignment with a linear superficial vessel appearance [16].…”

Section: Introductionmentioning

confidence: 99%

“…Characteristic dermoscopic features of the affected skin sites of the pseudoxanthoma elasticum patients according to the nomenclature of Berthin et al[15] and Kawashima et al[17]. Cont.…”

mentioning

confidence: 99%

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Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum

et al. 2021

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Pseudoxanthoma elasticum (PXE) is a rare multisystemic autosomal recessive connective tissue disease. In most cases, skin manifestations of PXE are the first to develop, followed later by severe ocular and cardiovascular complications. In our present study, in addition to dermoscopy, we introduced novel techniques, autofluorescence (AF) and diffuse reflectance (DR) imaging for the assessment of affected skin sites of five PXE patients. PXE-affected skin areas in most skin sites showed a previously observed pattern upon dermoscopic examination. With the novel imaging, PXE-affected skin lesions displayed high AF intensity. During our measurements, significantly higher mean, minimum and maximum AF intensity values were found in areas of PXE-affected skin when compared to uninvolved skin. Conversely, images acquired with the use of 660 and 940 nm illumination showed no mentionable difference. Our results demonstrate that AF imaging may be used in the in vivo diagnostics and quantification of the severity of the skin lesions of PXE patients. In addition, it is a safe, fast and cost-effective diagnostic method. AF imaging may be also used to objectively monitor the efficacy of the possible novel therapeutic approaches of PXE in the future.

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Section: Autofluorescence and Diffuse Reflectance Imaging With Narrowmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum

et al. 2021

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“…LOFDE papules clinically strongly mimic pseudoxanthoma elasticum (PXE) as well as the fibrotic phase of guttate morphea. In dermatoscopy, PXE reveals yellow-to-white clods on a reddish or whitish background, along with linear, irregular vessels, 6,7 whereas in HFUS, oval, homogeneous, hypoechogenic areas in the Yes dermis due to fat lobules herniations into atrophic skin, in for example, dermal striae. 9 Histology with elastic tissue stain will emphasize the distinctive elastic fibers arrangement in LOFDE, since elastic fibers are normal and increased in amount, while in dermal striae elastic fibers are curled and clumped at the edge of the lesion and reduced in the deep dermis enabling fat tissue hernia formation.…”

mentioning

confidence: 99%

Late‐onset Focal Dermal Elastosis—dermatoscopic and ultrasonographic assessment of this rare entity and literature review

Korecka,

Czuwara,

Szymoniak‐Lipska

et al. 2023

Skin Research and Technology

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Late-onset Focal Dermal Elastosis-dermatoscopic and ultrasonographic assessment of this rare entity and literature reviewDear Editor, Late Onset Focal Dermal Elastosis (LOFDE) is a rare, acquired cutaneous entity. Clinically, it usually presents as multiple, small, flat, white to pale yellow papules located on the sides of the neck and flexural areas. [1][2] The lesions might be asymptomatic or pruritic and generally occur in the elderly skin. Mainly women are affected. 3 In several reports regarding LOFDE, only a single case was described in a male patient. 4 The histopathological hallmark of LOFDE is the accumulation of the structurally normal elastic tissue in the mid and deep reticular dermis forming conglomerates pushing up collagen bundles. 3 Although LOFDE might clinically resemble pseudoxanthoma elasticum (PXE), their histopathological features differ, and no systemic disorders have been found in this condition. Other differential diagnoses include elastofibroma, papillary dermal elastolysis, nevus elasticus and Buschke-Ollendorff syndrome. 1 The pathogenesis of this entity is not known; however, some theories have been proposed. Since there are no clues of solar elastosis in histopathology, ageing not related to sun damage might have an impact on the appearance of the skin lesions. 3F I G U R E 1 Clinical image of LOFDE: (A) multiple white papules on the right thigh, (B) multiple white papules located unilaterally on the right shin.

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Pseudoxanthome élastique

Roy¹,

Jegou²

2021

Annales de Dermatologie et de Vénéréologie - FMC

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Dermoscopic phenotype of pseudoxanthoma elasticum skin lesions: a study of 16 patients

Cited by 4 publications

References 8 publications

Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum

Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum

Late‐onset Focal Dermal Elastosis—dermatoscopic and ultrasonographic assessment of this rare entity and literature review

Pseudoxanthome élastique

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