Dermoscopic Pattern of Psoriatic Lesions on Specific Body Sites

Lallas, Aimilios; Apalla, Zoe; Argenziano, Giuseppe; Sotiriou, Eleni; Lernia, Vito Di; Moscarella, Elvira; Longo, Caterina; Sidiropoulos, Theodoros; Zalaudek, Iris

doi:10.1159/000357914

Cited by 44 publications

(96 citation statements)

References 15 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The dermoscopic pattern of psoriasis has been adequately investigated, with regularly distributed dotted vessels known to represent the dermoscopic hallmark of the disease [6,10]. Specifically, it has been demonstrated that all psoriatic plaques regularly display distributed dotted vessels, even when located on specific body sites such as the scalp, palms/soles and folds [10].…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, it has been demonstrated that all psoriatic plaques regularly display distributed dotted vessels, even when located on specific body sites such as the scalp, palms/soles and folds [10]. The universal presence of dotted vessels in psoriatic plaques has led to the suggestion that the absence of such a vascular pattern should exclude the diagnosis of psoriasis [9].…”

Section: Discussionmentioning

confidence: 99%

“…In case of disagreement, a third investigator was involved. The dermoscopic variables were selected on the basis of available literature on dermoscopy of psoriasis and our initial observation that hemorrhagic dots represent a common finding in psoriatic lesions under treatment with biologic agents [6, 10–12]. An example highlighting the difference between hemorrhagic dots and the typical red dots of psoriasis is shown in Figure 1 and several additional examples of hemorrhagic dots in Figure 2.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Dermoscopic hemorrhagic dots: an early predictor of response of psoriasis to biologic agents

Lallas

Argenziano²,

Zalaudek

et al. 2016

Dermatol Pract Concept

Self Cite

View full text Add to dashboard Cite

BackgroundBiologic agents are routinely used in the treatment of severe psoriasis. The evaluation of treatment response is mainly based on the physician’s global clinical assessment.ObjectiveTo investigate whether dermoscopy might enhance the assessment of response of psoriasis to treatment with biologic agents.MethodsPatients with severe psoriasis scheduled to receive a biologic agent were enrolled in the study. A target lesion from each patient was clinically and dermoscopically documented at baseline and after one, two and six months. The clinical response was evaluated by the recruiting clinicians at all visits, while dermoscopic images were evaluated by two independent investigators, blinded to the clinical information. Chi Square test was used for cross-tabulation comparisons, while odds ratios, 95% confidence intervals and p values were calculated using univariate logistic regression.ResultsOverall, there was a significant correlation between clinical response and vessel distribution at all time points: a regular vessel distribution correlated with no response, a clustered distribution with partial response, and the dermoscopic absence of vessels with complete response. The presence of dermoscopic hemorrhagic dots was a potent predictor of favorable clinical response at the subsequent visit at all time points. Among lesions initially clinically responding and later recurring, 87.5% displayed dermoscopic dotted vessels despite the macroscopic remission.ConclusionDermoscopy might be a useful additional tool for evaluating the response of psoriatic patients to biologic agents. Hemorrhagic dots represent an early predictor of clinical response, while the persistence or reappearance of dotted vessels might predict clinical persistence or recurrence, respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Dermoscopic hemorrhagic dots: an early predictor of response of psoriasis to biologic agents

Lallas

Argenziano²,

Zalaudek

et al. 2016

Dermatol Pract Concept

Self Cite

View full text Add to dashboard Cite

show abstract

“…5b) [23, 28, 85]. Dotted vessels, which are regularly distributed (and only rarely in rings or patchy-distributed), may also be visible quite commonly when using a fluid interface (which reduce the scaling) [23]; focal yellowish scales are an additional but very rare finding [23, 28]. …”

Section: Acquired Keratodermasmentioning

confidence: 99%

Dermoscopy in General Dermatology: A Practical Overview

Errichetti

Stinco

2016

Dermatol Ther (Heidelb)

296

360

View full text Add to dashboard Cite

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides and subacute cutaneous lupus erythematosus), papulosquamous/papulokeratotic dermatoses (lichen planus, pityriasis rosea, papulosquamous sarcoidosis, guttate psoriasis, pityriasis lichenoides chronica, classical pityriasis rubra pilaris, porokeratosis, lymphomatoid papulosis, papulosquamous chronic GVHD, parakeratosis variegata, Grover disease, Darier disease and BRAF-inhibitor-induced acantholytic dyskeratosis), facial inflammatory skin diseases (rosacea, seborrheic dermatitis, discoid lupus erythematosus, sarcoidosis, cutaneous leishmaniasis, lupus vulgaris, granuloma faciale and demodicidosis), acquired keratodermas (chronic hand eczema, palmar psoriasis, keratoderma due to mycosis fungoides, keratoderma resulting from pityriasis rubra pilaris, tinea manuum, palmar lichen planus and aquagenic palmar keratoderma), sclero-atrophic dermatoses (necrobiosis lipoidica, morphea and cutaneous lichen sclerosus), hypopigmented macular diseases (extragenital guttate lichen sclerosus, achromic pityriasis versicolor, guttate vitiligo, idiopathic guttate hypomelanosis, progressive macular hypomelanosis and postinflammatory hypopigmentations), hyperpigmented maculopapular diseases (pityriasis versicolor, lichen planus pigmentosus, Gougerot-Carteaud syndrome, Dowling-Degos disease, erythema ab igne, macular amyloidosis, lichen amyloidosus, friction melanosis, terra firma-forme dermatosis, urticaria pigmentosa and telangiectasia macularis eruptiva perstans), itchy papulonodular dermatoses (hypertrophic lichen planus, prurigo nodularis, nodular scabies and acquired perforating dermatosis), erythrodermas (due to psoriasis, atopic dermatitis, mycosis fungoides, pityriasis rubra pilaris and scabies), noninfectious balanitis (Zoon’s plasma cell balanitis, psoriatic balanitis, seborrheic dermatitis and non-specific balanitis) and erythroplasia of Queyrat, inflammatory cicatricial alopecias (scalp discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia and folliculitis decalvans), nonscarring alopecias (alopecia areata, trichotillomania, androgenetic alopecia and telogen effluvium) and scaling disorders of the scalp (tinea capitis, scalp psoriasis, seborrheic dermatitis and pityriasis amiantacea).

show abstract

“…[4] The majority of the available evidence is in the field of papulosquamous skin diseases, including dermatitis, psoriasis, lichen planus, pityriasis rosea, and several others. [5][6][7][8][9][10][11][12][13] The dermoscopic criteria of these entities have been analytically described, and the diagnostic accuracy of dermoscopy in differentiating clinically equivocal cases has been assessed as significantly superior to clinical examination alone. [5] Furthermore, dermoscopy has been shown to add valuable morphologic information for the differential diagnosis between chronic dermatitis and mycosis fungoides, which might be extremely troublesome even histopathologically.…”

mentioning

confidence: 99%