Dermoscopic insight into skin microcirculation – Burn depth assessment

Mihara, Kyomi; Nomiyama, Tomoko; Masuda, Koji; Shindo, Hajime; Yasumi, Maki; Sawada, Takahiro; Nagasaki, Kotaro; Katoh, Norito

doi:10.1016/j.burns.2015.08.032

Cited by 8 publications

(13 citation statements)

References 36 publications

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“…A study of 30 burns, which were assessed between 4–166 h after injury, demonstrated an accuracy of 96.7% at distinguishing between superficial and deep dermal burns. 19 A study comparing infrared thermography, spectrophotometric intra-cutaneous analysis and LDI in adult patients with burns demonstrated that both thermography and spectrophotometry were less expensive, easier to use and more acceptable to patients than LDI. 20 …”

Section: 0 State Of the Sciencementioning

confidence: 99%

Burn Wound Healing and Tissue Engineering

Singer

Boyce

2017

Journal of Burn Care & Research

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Section: 0 State Of the Sciencementioning

confidence: 99%

Burn Wound Healing and Tissue Engineering

Singer

Boyce

2017

Journal of Burn Care & Research

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“…С другой стороны, изменения претерпевает и микроциркуляторное русло, в котором также имеет место дисфункция, однако эти сдвиги изучены существенно менее подробно. Это обусловлено тем обстоятельством, что в настоящее время спектр методов, позволяющих полноцен-но изучать состояние кровотока в различных зонах, крайне узок и представлен дерматоскопией [8] и гистологическим исследованием, приемлемым преимушественно для экспериментальных исследований, но не для широкого клинического использования [9][10][11]. В связи с этим, на практике для определения глубины ожога, локализации и состояния пограничной зоны ожога применяется визуальный метод [8], несмотря на не всегда высокую сопоставимость результатов его применения с гистологическими данными [12].…”

Section: Introductionunclassified

“…Это обусловлено тем обстоятельством, что в настоящее время спектр методов, позволяющих полноцен-но изучать состояние кровотока в различных зонах, крайне узок и представлен дерматоскопией [8] и гистологическим исследованием, приемлемым преимушественно для экспериментальных исследований, но не для широкого клинического использования [9][10][11]. В связи с этим, на практике для определения глубины ожога, локализации и состояния пограничной зоны ожога применяется визуальный метод [8], несмотря на не всегда высокую сопоставимость результатов его применения с гистологическими данными [12]. Следовательно, необходимы иные инструменты для оценки и детального описания состояния раневой поверхности как в ближайшем посттравматическом периоде [2,4,5,10], так и в динамике восстановительного периода.…”

Section: Introductionunclassified

Assessment of the Nature of the Microcirculatory Response to Experimental Thermal Injury

Мартусевич¹,

Yepishkina²,

Dilenyan³

2020

Vestnik of Ulyanovsk SAA

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Burn disease affects the functioning of almost all functional systems, having a negative effect on them due to the development of endotoxicosis and vascular disorders. At the same time, the greatest attention is paid to the shifts that form in the systemic hemodynamics, primarily in the coronary and pulmonary blood flow, which can cause the development and progression of life-threatening conditions. At the same time, the microcirculatory system is also undergoing changes, but these changes have been studied in much less detail. The aim of this research was to study the state of skin microcirculation in healthy and burned rats. The experiment was carried out on 20 adult male Wistar rats divided into two equal groups. The first group of animals (n=10) was a control group (intact), with its representatives there were not any manipulations, except for a single study of the state of microcirculation. Rats of the second (main) group (n=10) were simulated contact thermal burn using their own patented method. The assessment of microcirculation parameters in the main group of animals was carried out by laser Doppler flowmetry on the device "LAKK-M" on the 1st day (2-3 hours after the injury), on the third and tenth days after the burn period. It was found that thermal injury has a negative impact on the microcirculation system, which is seen in a decrease in the intensity of blood flow through small-diameter vessels. This is achieved by reflex vasospasm, reducing the release of nitrogen oxide by endothelial cells and activating precapillary sphincters, and simultaneously activating the shunting ways of cardiac shunt from the arterial directly to the venous channel, bypassing the capillaries. Thus, in the post-thermal period, a compensatory "robbing phenomenon" is realized in the border zone of the burn, which requires pathogenetic correction.

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“…In the experimental mammalian‐model setting where burns can be created using controlled temperatures and contact times, the corresponding histology has been used to characterize changes to determine the depth of injury. Despite the use of H&E as the gold standard in evaluating burn depth in experimental settings, there are published burn assessment studies that do not use H&E for comparison and instead use clinical assessment and photographs …”

mentioning

confidence: 99%

“…Despite the use of H&E as the gold standard in evaluating burn depth in experimental settings, 4 there are published burn assessment studies that do not use H&E for comparison and instead use clinical assessment and photographs. 10,11 One technique under development that does require histological evaluation as a gold standard is multispectral imaging (MSI), which is a noninvasive technology, based on the analysis of absorption and remission properties of light. The optical properties of normal and diseased skin can be distinguished when there are alterations in hemoglobin, water, melanin and collagen, as these molecules interact with light.…”

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confidence: 99%

Reconsidering the H&E stain as the gold standard in assessing the depth of burn wounds

Rosenberg

2017

J Cutan Pathol

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While histological examination is considered by most as the gold standard for burn depth assessment, it has no practical use in the clinical setting. It has, however, been used in the research setting, as a mean for evaluating emerging techniques of depth measurement. Due to the limitations of the H&E stain, other stains have also been explored, such as lactate dehydrogenase (LDH), as presented in this issue, in "Improving the Histologic Characterization of Burn Depth." As the determination of burn depth is not a typical subject in dermatopathology, a summary of selected techniques and the possible role for the LDH stain in future research, is described herein.

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Dermoscopic insight into skin microcirculation – Burn depth assessment

Cited by 8 publications

References 36 publications

Burn Wound Healing and Tissue Engineering

Burn Wound Healing and Tissue Engineering

Assessment of the Nature of the Microcirculatory Response to Experimental Thermal Injury

Reconsidering the H&E stain as the gold standard in assessing the depth of burn wounds

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