Dermoscopic findings and histopathological correlation in large cell acanthoma

Abstract

Since large cell acanthoma (LCA) has many overlapping clinical and histopathological features with other epidermal pigmented tumours, an additional method to differentiate it would be of great clinical significance. A retrospective study was performed on 33 lesions (26 patients) to identify distinct dermoscopic findings of LCA and to describe dermoscopic‐histopathological correlations. The results revealed that dermoscopy significantly aids in the distinction of LCA from other epidermal tumours included in the differential diagnosis. Yellow opaque homogeneous background, brown dots, and moth‐eaten border are common findings, and prominent skin markings and short white streaks are additional distinguishing features. Several important findings that are common in other diseases are rare in LCA.

Human Papillomavirus-Associated Giant Clear Cell Acanthoma and Squamous Cell Carcinoma: A Rare Case Report and Literature Review

“…Conversely, Švajdler et al in 2016 examined the presence of α-HPV and β-HPV in extragenital/extraungual Bowen's disease, finding a considerable proportion of lesions positive for high-risk HPV types, which could imply the etiological role of HPV in these precancerous conditions [26]. The literature also discusses the potential benefits of HPV vaccination in preventing NMSC, with some evidence suggesting that a beta-HPV vaccine could serve as an adjuvant treatment measure for patients with recalcitrant NMSC [22,66,67]. The role of HPV proteins in cancer development was explored by Balaji et al in 2022, who reviewed the mechanisms through which HPV proteins, especially E6 and E7 oncoproteins, contribute to carcinogenesis [68].…”

What's your diagnosis? A rare cutaneous benign tumor

“…Clinically, LCA may be difficult to be differentiated from a solar lentigo, a pigmented actinic keratosis, or a flat seborrheic keratosis 3 . A recently published study performed on 33 lesions (26 patients) identified distinct dermoscopic findings of LCA 4 . The most frequent dermoscopic findings are a yellow opaque homogenous area, grey/brown dots and globules, a moth-eaten border, white streaks, and a pseudonetwork 2,4 , most of which were also present in this case.…”

“…A recently published study performed on 33 lesions (26 patients) identified distinct dermoscopic findings of LCA 4 . The most frequent dermoscopic findings are a yellow opaque homogenous area, grey/brown dots and globules, a moth-eaten border, white streaks, and a pseudonetwork 2,4 , most of which were also present in this case. Another study evaluated 13 patients and also identified these as the most frequent dermoscopic features and found that milia-like cysts and white to yellow surface scale were uncommon findings 5 .…”