Dermoscopic changes in melanocytic nevi in patients receiving immunosuppressive and biologic treatments: Results of a prospective case-control study

The Natural History of Common Melanocytic Nevi: A Systematic Review of Longitudinal Studies in the General Population

“…The second study (Koseoglu et al, 2015), conducted in Turkey, included 60 healthy control subjects as part of a study examining nevus growth in patients receiving immunosuppressive treatment. Control subjects were matched to the patients by age, sex, race, and Fitzpatrick skin type.…”

“…In the US study (Tindall, 1976), age, sex, and race distributions of the study population were not provided, and no exact nevus counts were given overall or within demographic strata. The authors of the Turkish study (Koseoglu et al, 2015) did not specify from where or how the 60 matched control subjects were recruited and how representative they were of the general population. Neither did they note if there was any loss to follow up.…”

“…Also, the significance of the decrease in median nevus size they report seems unlikely given the small difference and sample size. For both studies (Koseoglu et al, 2015;Tindall, 1976) no description was given of the examiners or the counting and size measurement procedure, and thus the accuracy of the data cannot be assessed. EI Plasmeijer et al…”

Dermoscopic Features of Melanomas in Organ Transplant Recipients

“…Interestingly, most of these new naevi had a presence of a peripheral rim of globules, while this feature was not observed in pre-existing naevi. Koseoglu et al (9) performed a case-control investigation comparing a cohort of patients with systemic immunosuppressive treatment (266 melanocytic naevi in 103 patients) with healthy controls (180 lesions in 60 patients). Interestingly, naevi among the immunosuppressed patients displayed statistically significant dermoscopic changes compared with controls.…”

Clinical and dermoscopic features of nevi in patients with psoriasis

“…Recent publication about development of new nevi in patients using immunosuppressive agents showed that therapy with biologics was associated with increased nevi counts and appearance of dermoscopy changes in nevi, but none of the changes and the subsequently excised nevi were malignant [19] .…”