Dermatosis Papulosa Nigra

Dermatosis Papulosa Nigra in a Young Child

“…The reported frequency of DPN among blacks is variable. Whereas earlier surveys showed a 10% frequency (2), later ones reported 35% and 77% (3,4). Females, especially adolescents, are more frequently affected than males.…”

“…The diagnosis can be confirmed by biopsy. Microscopically, DPN resembles an acanthotic seborrheic keratosis (4,5). Typical histologic features include acanthosis, parakeratosis, and surface invagination of the epidermis, with the basal layer markedly hyperpigmerited compared with adjacent epidermis.…”

“…Hair follicles appear dilated and hyper- keratotic, and keratin-filled cysts are occasionally found (6). Although DPN can exhibit thick interwoven tracts of epithelial cells, the proliferation of small basal cells, which is prominent in seborrheic keratoses, is not a common feature of DPN (4).…”

A Randomized, Double-Blind Comparison of Two Topical Anesthesic Formulations Prior to Electrodesiccation of Dermatosis Papulosa Nigra

“…The extent of anesthesia (whether in terms of reduction of pain or absence of any sensation) and the depth of anesthesia (in millimeters) induced by percutaneously administered anesthetics depend on the duration of the application. 4,[18][19][20][21] Since DPN histologically involve essentially only the epidermis, 22 it may be that the full dermal analgesia that is required for painfree insertion of intravenous catheters and some other dermatologic procedures is not necessary for electrodesiccation of DPN. In addition, consonant with regional variability in skin thickness and blood flow rates, there are regional differences in rates of absorption and time to onset of anesthetic effects with topical anesthetic preparations.…”

Controversies in Dermatopathology

“…Delayed‐Onset Epithelial Hamartoma. Most authorities classify seborrheic keratoses as epithelial neoplasms 33,34. They contain basaloid cells, keratinocytes, and may or may not have melanocytes (Fig.…”