Dermatosis in magnesium-deficient hairless rats: Effects of steroidal and non-steroidal anti-inflammatory drugs

Abstract

Dermatosis in magnesium-deficient hairless rats has been described as a reproducible model of skin inflammation. It was therefore felt of interest to search for the effects of various anti-inflammatory compounds on this model. Results showed that 1) Dexamethasone acetate completely abolished the rash, 2) Indomethacin, a Non-Steroidal Anti-Inflammatory Drug (NSAID), inhibitor of the cyclooxygenase pathway was quite inactive, 3) Benoxaprofen, a NSAID inhibitor of both cyclooxygenase and lipoxygenase pathways only slightly modified the development of the pathology. Activity of steroidal anti-inflammatory drugs on this model may be related to their immunosuppressive effects.

Superoxide Anion in Polymorphonuclear Leukocytes of Hairless Rats Suffering from Magnesium‐deficiency Dermatitis

“…There may be variance in the on compensative ability among the rat strains. In contrast to zinc deficiency dermatitis, which usually involves acral or peri-oral skin (12), magnesium-deficient rats developed the rash mainly on the trunk. Peri-orificial regions, including the eyelids, were the site involved in common involved in both dermatoses.…”

“…As the mechanism of this dermatitis is obscure, great efforts have been made to elucidate the question by employing pharmacological or therapeutic techniques (1,2,10,12). The results of these reports show that anti-HI mepyramine and anti-H, cimetidine alone or in combination do not modify this dermatitis (1).…”

“…Cyc1ooxygenase inhibitors (aspirin and indomethacin) also failed to suppress it. It is of interest to note that benoxaprofen, an non-steroidal antiinflammatory drug, was slightly effective (12) and that both dexamethazone and magnesium compounds were completely effective, while histamine and prostaglandins did not affect the skin manifestations. This suggests that considerable attention should be paid to the metabolites via the lipoxygenase pathway as the pathological cause (10,12).…”

“…It is of interest to note that benoxaprofen, an non-steroidal antiinflammatory drug, was slightly effective (12) and that both dexamethazone and magnesium compounds were completely effective, while histamine and prostaglandins did not affect the skin manifestations. This suggests that considerable attention should be paid to the metabolites via the lipoxygenase pathway as the pathological cause (10,12). Our results showing that flurbiprofen, a cydo-oxygenase inhibitor, was not effective and that E1YA, an inhibitor of both pathways, was moderately effective also support the above-described etiology.…”

Magnesium-deficient hairless rat: Spleen cells mitogenic responses and variations in hormonal status

“…Dermatosis was induced and followed as previously described [3]. Briefly, ninety male hairless rats (Iffa-Credo, France), weighing about 200-250 g were included in these assays.…”