Dermatophytoses in Monterrey, México

Welsh, Oliverio; Welsh, Esperanza; Ocampo‐Candiani, Jorge; Gómez, Minerva; Vera-Cabrera, Lucio

doi:10.1111/j.1439-0507.2006.01199.x

Cited by 53 publications

(43 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Correlating the species with the anatomical localisation revealed that T. tonsurans was the most frequent isolate in scalp lesions (73.9%), whereas T. rubrum was the main species involved in body lesions (72.8%).Mexico. Welsh et al have published data fromMonterrey involving 2397 cases of dermatophytosis from superficial cutaneous lesions between 1978 and 1990 69. Seven hundred and twenty-six (30.2%) cases of tinea pedis, 613 (25.6%) of tinea unguium, 441 (18.4%) of tinea capitis, 395 (16.4%) of tinea corporis and 222 (9.3%) of tinea cruris were observed.…”

mentioning

confidence: 85%

Epidemiological trends in skin mycoses worldwide

Havlíčková¹,

Czaika

Friedrich³

2008

Mycoses

1,075

874

View full text Add to dashboard Cite

Fungal infections of the skin and nails are a common global problem. The high prevalence of superficial mycotic infections shows that 20-25% of the world's population has skin mycoses, making these one of the most frequent forms of infection. Pathogens responsible for skin mycoses are primarily anthropophilic and zoophilic dermatophytes from the genera Trichophyton (T.), Microsporum (M.) and Epidermophyton (E.). There appears to be considerable inter- and intra-continental variability in the global incidence of these fungal infections. Trichophyton rubrum, T. interdigitale (mentagrophytes var. interdigitale), M. canis, M. audouinii, T. tonsurans and T. verrucosum are the most common, but the attack rates and incidence of specific mycoses can vary widely. Local socio-economic conditions and cultural practices can also influence the prevalence of a particular infection in a given area. For example, tinea pedis (athlete's foot) is more prevalent in developed countries than in emerging economies and is likely to be caused by the anthropophilic germ T. rubrum. In poorer countries, scalp infections (tinea capitis) caused by T. soudanense or M. audouinii are more prevalent. This review summarises current epidemiological trends for fungal infections and focuses on dermatomycosis of glabrous skin on different continents.

show abstract

mentioning

confidence: 85%

Epidemiological trends in skin mycoses worldwide

Havlíčková¹,

Czaika

Friedrich³

2008

Mycoses

1,075

874

View full text Add to dashboard Cite

show abstract

“…27 Existe uma predominância de T. rubrum como principal agente etiológico em várias regiões geográ-ficas do mundo, como Japão, Estados Unidos, México e Brasil. 28 No entanto, alguns estudos mostram o aparecimento de outros dermatófitos como principais agentes causadores de infecção, entre eles o T. mentagrophytes e o M. canis. 29,30 A efetividade do tratamento tópico de infecções fúngicas continua sendo um importante desafio em dermatologia.…”

Section: Resultsunclassified

Glicoalcaloides antifúngicos, flavonoides e outros constituintes químicos de Solanum asperum

Pinto¹,

Uchôa²,

Silveira³

et al. 2011

Quím. Nova

View full text Add to dashboard Cite

Recebido em 7/6/10; aceito em 11/8/10; publicado na web em 26/11/10 ANTIFUNGAL GLYCOALKALOIDS, FLAVONOIDS AND OTHER CHEMICAL CONSTITUENTS OF Solanum asperum Rich (Solanaceae). Two glycoalkaloids: solamargine and solasonine; three flavonoids: tiliroside, 7-O-α-L-ramnopyranosyl-kaempferol and, in addition to the tripeptide Leu-Ile-Val, the aminoacid proline and the eicosanoic acid were isolated from Solanum asperum (Solanaceae). The structures of all compounds were determined by interpretation of their spectra (IR, MS, 1 H and 13 C NMR) and comparison with the literature data. All compounds, except the glycoalkaloids, are being reported for the first time for S. asperum. Solasonine showed strong activity (MIC < 0.24 mg/mL) against four filamentous fungi species of the genera Microsporum and Trichophyton.Keywords: Solanum asperum; antifungal glycoalkaloids; flavonoids. INTRODUÇÃOA família Solanaceae é representada por aproximadamente 2000 espécies distribuídas em 95 gêneros, sendo o taxon Solanum o mais representativo, com aproximadamente 1500 espécies e 5000 epítetos. As plantas que representam este gênero estão distribuídas preferencialmente nas áreas tropicais e subtropicais do planeta, sendo a América do Sul, o centro de maior diversidade e distribuição. 1 Uma grande fração do total de espécies descritas pode ser encontrada no Brasil, particularmente, na região Nordeste, onde são catalogadas cerca de 350 espécies. 2 Várias plantas deste gênero são popularmente conhecidas como "jurubebas", muitas das quais são largamente utilizadas na medicina popular, especialmente no tratamento de doenças da pele ou doenças relacionadas ao fígado e baço. 3,4 As plantas do gênero Solanum destacam-se pela capacidade de biossintetizar esteroides e alcaloides, livres ou na forma de heterosídeos, metabólitos secundários estruturalmente diversificados e complexos. 5,6 Estes compostos, em geral, são de interesse terapêutico, visto que apresentam um grande leque de atividades, como citotóxica, 5 anticâncer, 7 anti-inflamatória, 8 antiulcerogênica 9 e moluscicida. 10 Além disso, são também responsáveis pela resistência natural das espécies em seu ecossistema. 11 Compostos fenólicos, principalmente flavonas e flavonóis, incluindo seus heterosídeos, são também identificados com frequência em espécies de Solanum. 1,12 Como parte de um estudo multidisciplinar, cujo objetivo é investigar plantas da família Solanaceae, na busca por compostos bioativos, especialmente com atividade anticâncer, já foram isoladas várias lactonas esteroidais. 13,14 Neste trabalho é relatado o resultado obtido com a prospecção química de Solanum asperum Rich, popularmente conhecido como "coça-coça" ou "russara". As plantas desta espécie apresentam porte arbustivo e todas as suas partes são pulverulentas, isto é, ricas em pelos urticantes que se desprendem facilmente e que, em contato com a pele, provocam intensa coceira, daí o nome popular. Concomitante ao estudo químico foi ainda investigado o potencial antifúngico de algumas das substâncias isoladas.

show abstract

“…Our study showed that in most of the tinea cases the male: female ratio was quite similar, except for Tinea pedis (Female > males) and in tinea versicolor (Males > females). Welsh et al [16] reported that most of the cases were equally distributed in both genders, except for Tinea cruris which was more prevalent in men (3.5: 1 ratio). In the present study, the clinical diagnosis of 53 patients showed that 26.6% of patients were suffering from T.corporis followed by 22.6% with both T.pedis and T.versicolor, 18.9% of patients with T.cruris and Tinea capitis in only (9.4%).…”

Section: Discussionmentioning

confidence: 99%

Effect of Dermatophytes on Neutrophils and Monocytes Chemotaxis

Nasser¹

2016

MOJI

View full text Add to dashboard Cite

Introduction: Dermatophytes are a specialized group of fungi which affect keratinous tissue of humans and other vertebrates, causing superficial infections. Objectives:The current study aimed at investigating the chemotactic activity of a group of dermatophyte fungi towards neutrophils and monocytes. Material and methods:Fifty-three patients with superficial fungal infections of glabrous skin i.e. Tinea cruris, T. capitis, T. corporis and T. pedis were investigated. They were 28 females and 25 males aged 3-66 years old (average 32.7±15.3). In the present work, 26.6% (14/53) of these patients were suffering from T. corporis followed by T.pedis in 22.6% (12/53), T.versicolor in 22.6% (12/53), T.cruris in 18.8% (10/53) and T.capitis in 9.4% (5/53) of them. Fungal examination of the scaly lesions showed the presence of the following dermatophytes: Microsporum canis, Trichophyton rubrum, T. verrocosum and T.mentagrophytes. Neutrophils and monocytes separated from apparently healthy donors were tested for their migrating abilities using the under agarose (Nelson) technique. Different concentrations of fungal mycelia with or without normal serum were used in parallel to negative (tissue culture medium) and positive (zymosan activated serum) chemo attractants. Cell migration was measured by the leukotactic index (LI); the ratio of migration towards test/migration towards control.Results: Most of the tested dermatophyte concentrations were stimulatory for either neutrophil or monocyte chemotaxis (LI>1.0). It seemed that T.verrocosum was the most stimulatory one. Neutrophils were more actively migrating than monocytes as the differences between LIs of these cells were more than LSD at 5% (least significant difference). A non proportional dose-effect relationship between fungal concentration and chemotactic activity was observed. Conclusion:These data stress on the important role of neutrophil and monocyte in host defense against dermatophyte infection. The data also indicate that neutrophil is a more active responder to fungal infection than monocyte. Keywords Material and Methods Study groupFifty-three patients with superficial fungal infections of glabrous skin attended the Dermatology and Venereology outpatient clinic of Al-Hussien University Hospital, were studied during a period from May 2000 to September 2001. They were 28 females their age ranged from 5-55 (25.3±14) years and 25 males their age ranged from 3-66 (30.2±16.6) years old. A full history was taken from all patients including age, job, site of infection, presence of predisposing factors and antifungal treatment. The duration of the disease in 51 patients varied from 112 weeks (recent infection). In the remaining two patients, the duration of infection was more than 12 months (chronic infection). The patients were suffering from superficial dermatophytosis; no other skin infections or systemic diseases were detected.Mycological examination was done for all patients. Antifungal sensitivity testing and chemotaxis assay were done for positive culture...

show abstract

Dermatophytoses in Monterrey, México

Cited by 53 publications

References 13 publications

Epidemiological trends in skin mycoses worldwide

Epidemiological trends in skin mycoses worldwide

Glicoalcaloides antifúngicos, flavonoides e outros constituintes químicos de Solanum asperum

Effect of Dermatophytes on Neutrophils and Monocytes Chemotaxis

Contact Info

Product

Resources

About