Dermatophytes and related keratinophilic fungi in soil of parks and agricultural fields of Uttar Pradesh, India

Singh, Itisha; Kushwaha, R. K. S.

doi:10.4103/0019-5154.70700

Cited by 12 publications

(4 citation statements)

References 2 publications

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“…M. gypseum is a geographically widespread geophilic fungus, it has a latent ability to infect animals as well as the keratinous tissues of humans,[ 7 ] It has been also to verified that by histopathologic examination of a skin biopsy from the lesion in our subject. Infection with this organism often results from direct contact with either soil or domestic pets.…”

Section: Discussionmentioning

confidence: 99%

Pseudomembranous-like tinea of the scrotum infected by Microsporum gypseum in a young man

Lan

Zhou

et al. 2015

Indian J Dermatol

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Section: Discussionmentioning

confidence: 99%

Pseudomembranous-like tinea of the scrotum infected by Microsporum gypseum in a young man

Lan

Zhou

et al. 2015

Indian J Dermatol

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“…Symptoms of infections in these animals can be observed only in certain host immune deficiency states, which are a major factor in subsequent treatment failures [32,95]. Moreover, more intensive contact of animals with soil may favour the easy acquisition of infectious elements of dermatophytes, for which soil is one of the most important reservoirs [75,[96][97][98].…”

Section: Discussionmentioning

confidence: 99%

Population differentiation, antifungal susceptibility, and host range of Trichophyton mentagrophytes isolates causing recalcitrant infections in humans and animals

Gnat

Łagowski

Nowakiewicz

et al. 2020

Eur J Clin Microbiol Infect Dis

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The major problems in determining the causative factors of the high prevalence of dermatophytoses include the lack of a well-standardized antifungal susceptibility testing method, the low consistency of in vitro and clinical minimal inhibitory concentration values, the high genomic diversity of the population, and the unclear mechanism of pathogenicity. These factors are of particular importance when the disease is recalcitrant and relapses. Herein, we identified and characterized Trichophyton mentagrophytes isolates obtained from therapy-resistant cases in humans and animals. We used genomic diversity analysis of 17 human and 27 animal clinical isolates with the MP-PCR technique, determined their phenotypic enzymatic activity and host range, and performed antifungal susceptibility testing to currently available antifungal drugs from various chemical groups. Genomic diversity values of 35.3% and 33.3% were obtained for clinical isolates from humans and animals, respectively, yet without any relationship to the host species or antifungal drug to which resistance in therapy was revealed. The highest activity of keratinase enzymes was recorded for fox, guinea pig, and human hairs. These hosts can be considered as the main species in the host range of these isolates. A phenyl morpholine derivative, i.e. amorolfine, exhibited superior activity against strains obtained from both humans and animals with the lowest MIC50. Interestingly, high compliance of terbinafine in vitro resistance with clinical problems in the treatment with this substance was shown as well. The high resistance of dermatophytes to drugs is the main cause of the recalcitrance of the infection, whereas the other features of the fungus are less important.

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“…Since the report of the degradable keratin of Onygena equina ( 9 ), new taxa of keratinophilic fungi and their applications have been reported. Keratinophilic fungi involve a large number of taxa belonging to several orders, families, and genera, including mainly dermatophytes and some saprophytic fungi, such as some species of Arthrodermataceae and Onygenaceae in the order Onygenales ( 10 ) and some members of the genera Geomyces and Pseudogymnoascus in the order Thelebolales ( 11 ). In addition, they contain a large number of common taxa, such as some species of the genera Aspergillus , Penicillium , and Trichoderma ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Culturable Fungi from Urban Soils in China I: Description of 10 New Taxa

Zhang

Shao

et al. 2021

Microbiol Spectr

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Dermatophytes and related keratinophilic fungi in soil of parks and agricultural fields of Uttar Pradesh, India

Cited by 12 publications

References 2 publications

Pseudomembranous-like tinea of the scrotum infected by Microsporum gypseum in a young man

Pseudomembranous-like tinea of the scrotum infected by Microsporum gypseum in a young man

Population differentiation, antifungal susceptibility, and host range of Trichophyton mentagrophytes isolates causing recalcitrant infections in humans and animals

Culturable Fungi from Urban Soils in China I: Description of 10 New Taxa

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