Abstract:Dermatophytes and other members of Onygenales are unique in their ability to degrade keratin, affecting hair and nails, and in case of human hosts cause infection of the skin. Subtillisins are essential proteases in keratin assimilation, and subtilisin-like protease 1 (SUB1) and SUB3–7 are specific for dermatophytes. eIF2α kinases are serine-threonine kinases that perform essential functions in response to infection, proteotoxicity, and nutrient scavenging. The relatively conserved nature of EIF2AK4 among fung… Show more
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