Dermatophyte infection caused by Nannizzia gypsea : A rare case report from Madagascar

Soankasina, Abel Hermann; Rakotozandrindrainy, Njariharinjakamampionona; Andrianteloasy, Solohery; Zafindraibe, Norosoa Julie; Rasamoelina, Tahinamandranto; Rafalimanana, Christian; Cornet, Muriel; Razanakolona, Lala Rasoamialy; Rasamindrakotroka, Andry; Andrianarivelo, Mala Rakoto

doi:10.1016/j.mmcr.2017.12.001

Cited by 11 publications

(5 citation statements)

References 14 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of infection rates is assessed at approximately 1% of all dermatophytoses, although in some regions it can reach up to 7% (Seebacher et al 2008;Jankowska-Konsur et al 2011;Vena et al 2012;Hubka et al 2015). This group of dermatophytes comprises a high and still rising number of species, which in part is related to the increasing use of molecular methods in species identification (Gnat et al 2019f, 2019e) Moreover, in the last few years, several presumed soil dermatophytes have been isolated from clinical material (Dolenc-Voljc and Gasparic 2017;Soankasina et al 2017;Gnat et al 2019a). Nonetheless, geophilic dermatophytes are regarded as rather opportunistic pathogens as well as keratinophilic fungi with ecological importance, since they are involved in keratin degradation (Ginter-Hanselmayer et al 2007;de Hoog et al 2017).…”

Section: Problems In Diagnosis and Treatment Of Dermatophytosesmentioning

confidence: 99%

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

2020

View full text Add to dashboard Cite

Dermatophytes are the aetiological factors of a majority of superficial fungal infections. What distinguishes them from other pathogenic filamentous fungi is their unique ability to degrade keratin. The remarkable ability of this group of fungi to survive in different ecosystems results from their morphological and ecological diversity as well as high adaptability to changing environmental conditions. Paradoxically, despite the progress in medicine, the prevalence of dermatophyte infections is increasing from year to year. At the beginning of the third millennium, practical diagnostic and therapeutic options are still very limited. This review focuses on understanding the major problems in this aspect of dermatophyte infections and indicates future strategies and perspectives for novel approaches to identification and drugs for elimination of dermatophytes. Particular importance is placed on development of a strategy for a diagnostic pathway and implementation of rapid and reliable diagnostics methods designed by international teams. Furthermore, among compounds that currently arouse great interest, representatives of terpenoids, alkaloids, saponins, flavonoids and essential oils deserve attention. Many of these compounds are undergoing clinical trials as potential antifungal agents, and future research should focus on attempts at determination of the applicability of tested substances. Finally, the advantages and disadvantages in implementation of new diagnostic paths and medicinal substances for routine use are indicated. Journal of Applied Microbiology

show abstract

Section: Problems In Diagnosis and Treatment Of Dermatophytosesmentioning

confidence: 99%

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

2020

View full text Add to dashboard Cite

show abstract

“…Soankasina and colleagues described an interesting case of dermatophytosis of the smooth skin (tinea corporis) in a 22-year-old woman from the Madagascar region. A detailed medical history revealed that she probably contracted the infection through contact with free-living cats [89]. Infection with N. gypsea by contact with an infected animal has also been observed in a 2-year-old boy from Italy with signs of infection on the scalp [90].…”

Section: Discussionmentioning

confidence: 97%

Diversity of Soil-Borne Fungi Isolated from Places Frequently Visited by People in the City of Wrocław (Poland)

Spychała,

Kłosińska,

Salwińska

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

In this study, we identified culturable microscopic fungi in soil from areas frequented by people (parks, allotments, and other green areas) in the city of Wrocław (Poland). In addition to general species analysis, attention was focused on keratin-degrading fungi. From 60 soil samples (12 study sites), we obtained 75 isolates of keratinophilic and keratinolytic fungi using the hair bait method, and 54 isolates of fungi were isolated on PDA (Potato Dextrose Agar) medium. Based on morphological and molecular analyses, a total of 37 strains were identified, classified into 2 phyla, 11 families, 17 genera, and 30 filamentous species. The mean values of the Shannon Diversity Index for both experimental variants ranged from 0.074 to 0.117. The most common species was the Penicillium genus, which accounted for 33.33% of all fungal species obtained in these studies. These fungi are common in both indoor and outdoor environments. However, particularly noteworthy in this study are the species belonging to the group of dermatophytes (Arthroderma uncinatum, Keratinophyton wagnerii, Nannizzia gypsea, and Paraphyton cookei), which may pose a real biological threat to humans and animals due to their well-known potential to cause dermatomycosis.

show abstract

“…Recently, an interesting case of Tinea incognito caused by N. gypsea was reported in a 22-year-old immunocompetent female from Madagascar with contact of cats and without any apparent contact with soil. The lesions were presented as solitary, round with circinate scaly plaques with well-defined erythematous lesions and peripheral active zone filled with small vesicles [ 19 ]. The present case also records a unique clinical presentation, which is in agreement with the previously described lesions caused by N. gypsea .…”

Section: Discussionmentioning

confidence: 99%

Naive tinea corporis et cruris in an Immunocompetent adult caused by a geophile Nannizzia gypsea susceptible to Terbinafine–Rarity in the current scenario of Dermatophytosis in India

Vanam

Mohanram

Reddy

et al. 2019

Access Microbiology

View full text Add to dashboard Cite

Introduction Dermatophytosis caused by Nannizzia gypsea formerly Microsporum gypse um is rare in occurrence due to its geophilic adaptation and weak pathogenic potential in establishing infection in humans. The taxonomical status of N. gypsea has been controversial over the years and has now reached a concordance among mycologists. Innumerable reports of N. gypsea causing widespread infection in human immunodeficiency virus patients trails them as an important agent of consideration in an immunocompromised host. There have been sporadic reports of N. gypsea causing glabrous skin tinea and onychomycosis in healthy patients and the prevalence reports gravitate around 1–6.5 %. A variety of non-anthropophilic dermatophytes including novel species have now been implicated in causing dermatophytosis reflecting the era of crux changes in the epidemiology. Case report We present a case of chronic dermatophytosis in a 22-year-old healthy Indian with a history of contact with a dog and soil and other factors favouring dermatophytosis. Conventional and molecular sequencing established the isolate as N. gypsea . Antifungal susceptibility test revealed a higher MIC of griseofulvin and lower MIC to azoles and terbinafine. The patient had complete clinical resolution following administration of oral terbinafine. Conclusion Amidst the hyper-endemic-like scenario of tinea in India, this case report stands as a unique example of a patient infected with N. gypsea showing complete clinical resolution using terbinafine. Studies implicating N. gypsea in an immunocompetent host are rare and there is a need for more studies on geophilic dermatophytes causing tinea in the man for laying down effective preventive measures.

show abstract

Dermatophyte infection caused by Nannizzia gypsea : A rare case report from Madagascar

Cited by 11 publications

References 14 publications

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

Major challenges and perspectives in the diagnostics and treatment of dermatophyte infections

Diversity of Soil-Borne Fungi Isolated from Places Frequently Visited by People in the City of Wrocław (Poland)

Naive tinea corporis et cruris in an Immunocompetent adult caused by a geophile Nannizzia gypsea susceptible to Terbinafine–Rarity in the current scenario of Dermatophytosis in India

Contact Info

Product

Resources

About