Dermatopathologic effects of taxane therapy

Taxanes‐induced cutaneous eruption: another histopathologic mimicker of malignancy

“…Other chemotherapeutic drugs may also cause histopathologic changes that may mimic malignancy. 2,[34][35][36][37][38] Microtubule-targeting drugs, such as vincristine, [38][39][40][41] podophyllin, [39][40][41] and its derivative etoposide, 37 colchicine, 42,43 maytansine 44 and bulsulfan 45 may produce histopathologic changes similar to taxanes, and should be included in the differential diagnosis. Condyloma acuminata treated with podophyllin may show atypical mitoses simulating squamous cell carcinoma.…”

“…The resulting figures of mitotic arrest and apoptosis have been observed histopathologically in several tissues, including the skin. 2,3 We present six cases of skin eruptions induced by taxanes with remarkable histopathological findings, which posed a diagnostic challenge.…”

Toxic erythema with eccrine squamous syringometaplasia induced by nanoparticle albumin‐bound paclitaxel

“…1 Increased mitoses of keratinocytes by taxane administration can result in eccrine squamous syringometaplasia (ESS) which simulates histopathological features of squamous cell carcinoma. 2 Here, we report a case of toxic erythema with ESS induced by nanoparticle albumin-bound paclitaxel (Nab-PTX; Abraxane â ; Taiho Pharmaceutical Co., Ltd., Tokyo, Japan), and also analyzed the expression of cell-cycle-related molecules, p53 and cycline D1 (CyD1).…”

Benign reactive lesion with atypical mitosis: New example of an old story

“…However, demonstrating atypical mitotic figures in a benign reactive lesion is not something new, but is rare finding in both experimental and surgical pathology related to inflammatory or regenerative processes [1][2][3][4][5][6][7][8]. One may argue that some of above mentioned chronic pathological processes, for example, long standing ulcerative colitis [4] and gastric intestinal metaplasia [5], are associated with malignant potential.…”

“…After over one century, a general consensus has been reached in the surgical pathology society, stating that an atypical mitotic figure may indicate a malignant process while it can also be seen in benign lesions. For example, atypical mitotic figures can be occasionally found in granulation tissue following ionizing-radiation exposur, ischemic colitis, long standing ulcerative colitis, gastric intestinal metaplasia, endometrium associated with chorionic tissue effect, benign cutaneous lesions induced by taxane therapy, and abnormal but non-neoplastic astrocytes [2][3][4][5][6][7][8]. Herein, a rare case of ischemic fasciitis, also named as atypical decubital fibroplasia, is reported, which shows typical clinical and histological features, except that atypical mitosis is evident.…”