Dermatoniyositis and polymyositis

Targoff, Ira N.

doi:10.1016/1040-0486(91)90010-2

Cited by 18 publications

(5 citation statements)

References 179 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibodies against an antigen called Jo-1 were found in 20 -30% of the sera of myositis patients (Mathews and Bernstein, 1983;Dang et al, 1985Targoff et al, 1988;Targoff and Arnett, 1990;Marguerie et al, 1990;Goldstein et al, 1990;Tsui and Siminovitch, 1991;Shi et al, 1991;Lopez et al, 1991;Targoff, 1991Targoff, , 1993Hirakata et al, 1992;Treher et al, 1993;Garlepp, 1993;O'Neill and Maddison, 1993;Mitra et al, 1994;O'Hanlon et al, 1994;Chmiel et al, 1995;Fischer et al, 1995;Gelpi et al, 1996;Vazquez-Abad and Rothfield, 1996a;Friedman et al, 1996;Rutjes et al, 1997;Kalenian and Zweiman, 1997;Miller et al, 1998). Immunoblot assays (Williams et al, 1986;Fonong et al, 1990) and ELISA tests were developed (Biswas et al, 1987b;Targoff and Reichlin, 1987) for detection of anti-Jo-1, which does not seem to correlate with cellular muscle damage (Suzuki et al, 1993).…”

Section: Histidyl-trna Synthetase In Autoimmune Diseasesmentioning

confidence: 99%

Histidyl-tRNA Synthetase

Freist¹,

Jf²,

Rühlmann³

et al. 1999

Biological Chemistry

View full text Add to dashboard Cite

Histidyl-tRNA synthetase (HisRS) is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. This amino acid has uniquely moderate basic properties and is an important group in many catalytic functions of enzymes.A compilation of currently known primary structures of HisRS shows that the subunits of these homodimeric enzymes consist of 420 -550 amino acid residues. This represents a relatively short chain length among aminoacyl-tRNA synthetases (aaRS), whose peptide chain sizes range from about 300 to 1100 amino acid residues.The crystal structures of HisRS from two organisms and their complexes with histidine, histidyl-adenylate and histidinol with ATP have been solved. HisRS from Escherichia coli and Thermus thermophilus are very similar dimeric enzymes consisting of three domains: the N-terminal catalytic domain containing the sixstranded antiparallel ␤-sheet and the three motifs characteristic of class II aaRS, a HisRS-specific helical domain inserted between motifs 2 and 3 that may contact the acceptor stem of the tRNA, and a C-terminal ␣/␤ domain that may be involved in the recognition of the anticodon stem and loop of tRNA His .The aminoacylation reaction follows the standard two-step mechanism. HisRS also belongs to the group of aaRS that can rapidly synthesize diadenosine tetraphosphate, a compound that is suspected to be involved in several regulatory mechanisms of cell metabolism. Many analogs of histidine have been tested for their properties as substrates or inhibitors of HisRS, leading to the elucidation of structure-activity relationships concerning configuration, importance of the carboxy and amino group, and the nature of the side chain.HisRS has been found to act as a particularly important antigen in autoimmune diseases such as rheumatic arthritis or myositis. Successful attempts have been made to identify epitopes responsible for the complexation with such auto-antibodies.

show abstract

Section: Histidyl-trna Synthetase In Autoimmune Diseasesmentioning

confidence: 99%

Histidyl-tRNA Synthetase

Freist¹,

Jf²,

Rühlmann³

et al. 1999

Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…Dermatomyositis (DM), as an idiopathic inflammatory myopathy, is associated with increased risk of malignant disease [ 1 ]. Non-Hodgkin’s lymphoma and ovarian, lung, gastric, colorectal, and pancreatic cancers are all commonly associated with DM [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Dermatomyositis in a Patient with Cholangiocarcinoma Detected by an [<sup>18</sup>F]-Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography Scan

et al. 2016

View full text Add to dashboard Cite

Cholangiocarcinoma with paraneoplastic dermatomyositis (DM) is extremely rare, and the whole body positron emission tomography-computed tomography (PET-CT) finding of paraneoplastic DM is rarely reported. We report a 66-year-old woman with metastatic cholangiocarcinoma, initially presented with bilateral proximal muscle uptake on PET-CT without clinical muscle symptoms. The initial interpretation of the high muscle uptake was metastasis to the muscles. However, while awaiting for chemotherapy, muscle weakness evolved and rapidly progressed. The level of creatine phosphokinase was significantly elevated. Electromyography revealed moderate myopathy, and a muscle biopsy showed degenerating myofibers with variable sizes. The diagnosis of paraneoplastic dermatomyositis was made. This case highlights that, although rare, paraneoplastic dermatomyositis can be present with cholangiocarcinoma. Also, muscle inflammation can precede the clinical muscle symptoms, and paraneoplastic DM should be considered as a possible differential diagnosis in the assessment of cancer patients who present with abnormal muscle tracer uptake in PET-CT scans.

show abstract

“…Inflammatory myopathies occur in children and adults, either as apparently primary events or associated with other systemic disorders, particularly defined connective tissue diseases such as systemic lupus erythematosus (SLE) (21). Studies by several groups have detected a variety of autoantibodies in the sera of patients with primary inflammatory myopathy (5,16,22).…”

mentioning

confidence: 99%

“…Primary inflammatory myopathies typically affect the proximal muscles more than the distal muscles, generally without atrophy or contractures (13,21). There is involvement of esophageal muscles with dysphagia in about 25% of cases, and cardiac myositis occurs in about 30% of cases, leading to arrhythmia and/or congestive heart failure.…”

mentioning

confidence: 99%