Dermatomyositis without muscle weakness. Long-term follow-up of 12 patients without systemic corticosteroids

Cosnes, A.

doi:10.1001/archderm.131.12.1381

Cited by 48 publications

(39 citation statements)

References 20 publications

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“…Compared with matched controls, three aDM patients selected from a previous study (Cosnes et al, 1995) had myofiber capillarization decreased by 45%, as previously reported (Emslie-Smith and Engel, 1990). Importantly a roughly proportionate decrease (53%) in the mean SC number per myofiber ( Figure 2H) was also observed.…”

Section: Muscle Capillary Loss Is Associated With Proportionate Sc Desupporting

confidence: 79%

“…We used aDM as a paradigm of pure capillary loss, typically observed in the absence of both myofiber damage and inflammation (Emslie-Smith and Engel, 1990;Cosnes et al, 1995). Compared with matched controls, three aDM patients selected from a previous study (Cosnes et al, 1995) had myofiber capillarization decreased by 45%, as previously reported (Emslie-Smith and Engel, 1990).…”

Section: Muscle Capillary Loss Is Associated With Proportionate Sc Dementioning

confidence: 97%

“…Muscle samples were also collected from deltoid muscle of 3 heavy-training athletes who had no significant myopathologic alterations (males aged from 32 to 39 y practicing intense daily push-up training), of 3 patients with amyopathic dermatomyositis (aDM) collected from a previous study (Cosnes et al, 1995; 2 females, 1 male aged from 32 to 39 y), and of 3 boys with Duchenne muscular dystrophy (DMD; males aged from 2 to 14 y). Muscle samples were frozen and kept at Ϫ80°C before processing.…”

Section: Muscle Samplesmentioning

confidence: 99%

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Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners

Christov

Chrétien

Abou-Khalil

et al. 2007

MBoC

568

601

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Genetically engineered mice (Myf5 nLacZ/؉ , Myf5GFP-P/؉ ) allowing direct muscle satellite cell (SC) visualization indicate that, in addition to being located beneath myofiber basal laminae, SCs are strikingly close to capillaries. After GFP ؉ bone marrow transplantation, blood-borne cells occupying SC niches previously depleted by irradiation were similarly detected near vessels, thereby corroborating the anatomical stability of juxtavascular SC niches. Bromodeoxyuridine pulse-chase experiments also localize quiescent and less quiescent SCs near vessels. SCs, and to a lesser extent myonuclei, were nonrandomly associated with capillaries in humans. Significantly, they were correlated with capillarization of myofibers, regardless to their type, in normal muscle. They also varied in paradigmatic physiological and pathological situations associated with variations of capillary density, including amyopathic dermatomyositis, a unique condition in which muscle capillary loss occurs without myofiber damage, and in athletes in whom capillaries increase in number. Endothelial cell (EC) cultures specifically enhanced SC growth, through IGF-1, HGF, bFGF, PDGF-BB, and VEGF, and, accordingly, cycling SCs remained mainly juxtavascular. Conversely, differentiating myogenic cells were both proangiogenic in vitro and spatiotemporally associated with neoangiogenesis in muscular dystrophy. Thus, SCs are largely juxtavascular and reciprocally interact with ECs during differentiation to support angio-myogenesis. INTRODUCTIONMuscle tissue repair is a complex biological process that crucially involves activation of stem cells. Skeletal muscle contains two different stem cell types: 1) myogenic stem cells, so-called satellite cells (SCs), that reside beneath the basal lamina of muscle fibers (Mauro, 1961) and express both NCAM/CD56 and early myogenic cell markers such as M-cadherin, Pax7, and Myf5 (Beauchamp et al., 2000;Seale et al., 2000;Hawke and Garry, 2001; Bischoff and FranziniArmstrong, 2004) and 2) interstitial multipotent stem cells, which are extralaminal, exhibit fibroblastic morphology and do not express myogenic markers (Asakura et al., 2001;Tamaki et al., 2002). SCs are primarily quiescent in skeletal muscle, can self-renew (Collins et al., 2005) and upon activation, proliferate and further differentiate to become fusioncompetent myoblasts and ensure muscle regeneration (Hawke and Garry, 2001;Bischoff and Franzini-Armstrong, 2004). Interstitial "muscle-derived" stem cells give rise to several lineages after transplantation and in this setting, contribute to synchronized reconstitution of blood vessels (pericytes, smooth muscle cells [SMCs], and endothelial cells), peripheral nerve (Schwann cells), and muscle cells (myofibers and SCs; Tamaki et al., 2005). However, participation of multipotent interstitial stem cells in physiological muscle repair appears to be limited. Instead, it is widely accepted that sublaminal SCs represent the pre-eminent muscle stem cell type used for muscle growth, repair and regeneration (Dhawan...

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Section: Muscle Capillary Loss Is Associated With Proportionate Sc Desupporting

confidence: 79%

Section: Muscle Capillary Loss Is Associated With Proportionate Sc Dementioning

confidence: 97%

Section: Muscle Samplesmentioning

confidence: 99%

See 1 more Smart Citation

Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners

Christov

Chrétien

Abou-Khalil

et al. 2007

MBoC

568

601

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“…Cosnes et al [29] reported positive ANA test results in eight of 12 patients (66%) without muscle weakness. These reports can be contrasted with the earlier report of Krain [4] in which ANA positivity was noted in only one of six patients (16%).…”

Section: Immunologic Featuresmentioning

confidence: 96%

Amyopathic dermatomyositis

Olsen¹,

Park²,

KingJr³

2001

Curr Rheumatol Rep

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Amyopathic dermatomyositis is a variant of dermatomyositis that is characterized by the typical skin rash but without the muscle abnormalities. It has been proposed that the amyopathic and myopathic forms of dermatomyositis exist on a continuum, a concept that is supported by family and genetic studies and the observation that a small proportion of amyopathic patients transform to a frankly myopathic state. The amyopathic state is defined by a lack of muscle weakness and through diagnostic tests, including serum muscle enzymes, electromyogram studies, and muscle biopsies, that are usually normal or show only minimal abnormalities. Despite the lack of weakness, many patients complain of debilitating fatigue. More sensitive measures of muscle function, such as P-31 magnetic resonance spectroscopy, suggest that muscle metabolism is abnormal in amyopathic patients. The amyopathic form is more commonly seen in adults than in children, although juvenile cases are reported. Some early series suggested no association with underlying malignancies, but recent reports indicate that malignancies occur. Determining whether a patient has amyopathic rather than myopathic disease may have prognostic implications.

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“…Review CME Vleugels & Callen Additional small studies demonstrated similar favorable results with hydroxychloroquine used for cutaneous disease in adult patients, including those with ADM, and in pediatric patients with DM [26][27][28][29]. In a pediatric study, however, three out of nine patients developed ocular side effects that mandated discontinuation of hydroxychloroquine [29].…”

Section: Antimalarialsmentioning

confidence: 99%