Dermatomyositis related to autoimmune thyroiditis

Wang, Han; Tao, Li-En; Li, H; Deng, Juelin

doi:10.1111/j.1468-3083.2010.03929.x

Cited by 9 publications

(9 citation statements)

References 48 publications

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“…The fatigue‐associated variables such as thyroid disease in ADM and female sex in SLE are consistent with past studies. Fatigue is a hallmark symptom in thyroid disease, and autoimmune thyroid dysfunction is particularly common in dermatomyositis . Fatigue has also been found to be more prevalent in women …”

Section: Discussionmentioning

confidence: 99%

Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

et al. 2019

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Summary Background Fatigue is a well‐established symptom in systemic lupus erythematosus (SLE), but has not been well characterized in other skin‐limited autoimmune diseases such as cutaneous lupus erythematosus (CLE), amyopathic dermatomyositis (ADM) or autoimmune blistering diseases (AIBD). Objectives In this retrospective study, we compared fatigue in controls (n = 84) with that in patients enrolled in prospective longitudinal databases with SLE (n = 165), CLE (n = 226), ADM (n = 136) and AIBD (n = 79). Methods We used the 36‐Item Short Form Survey (SF‐36) vitality scale to analyse median scores and the percentages of patients with clinically significant fatigue (defined as a score ≤ 35) between experimental groups and controls. Results Median and interquartile range (IQR) vitality scores demonstrated greater fatigue in the experimental groups (SLE 35, IQR 20–55; CLE 50, IQR 30–70; ADM 50, IQR 30–65; AIBD 55, IQR 35–70) than in controls (73, IQR 65–85) (P < 0·05 for each experimental group vs. control). The SLE group had worse fatigue than all of the other groups (P < 0·05 SLE vs. each group), but there was no difference between the CLE, ADM or AIBD groups (all P > 0·05). In addition, the experimental groups had more clinically significant fatigue (score ≤ 35) (SLE 44·2%, CLE 25·2%, ADM 31·6%, AIBD 24·1%) than controls (2%) (P < 0·01 for each experimental group vs. control). The SLE group had more clinically significant fatigue than the CLE group (P < 0·01); however, there was no difference in clinically significant fatigue between SLE and either ADM (P = 0·17) or AIBD (P = 0·055). Conclusions These findings demonstrate that patients with skin‐limited autoimmune disease experience more fatigue than controls. Fatigue is an important symptom that negatively affects quality of life for patients. It should be addressed by clinicians and measured in future clinical trials.

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Section: Discussionmentioning

confidence: 99%

Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

et al. 2019

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“…Given the known association of autoimmune thyroiditis with DM, the patient was likely genetically predisposed to DM development, and lacosamide may have acted as an environmental trigger. 6 Lacosamide, a third-generation antiepileptic drug (AED), acts on neuronal voltage-gated sodium channels and has only been previously described to cause cutaneous manifestations through hypersensitivity reactions. 7 The mechanism for drug-induced DM remains unclear; however, it has been proposed that certain drugs may inflict damage to endothelial cells leading to release of cellular antigens and epitope spreading, which causes an autoimmune reaction.…”

Section: Discussionmentioning

confidence: 99%

Drug-induced dermatomyositis after lacosamide: A case report

2018

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“…It is possible that our patient also had a history of autoimmune thyroiditis, given the elevated antithyroperoxidase antibody. Interestingly, several case reports have described an association between DM and autoimmune thyroiditis 11 12. Wang et al 12 identified 3 of 11 patients in their review of DM and autoimmune thyroiditis who had thyroidectomy for nodular goitres before a diagnosis of DM was made.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, several case reports have described an association between DM and autoimmune thyroiditis 11 12. Wang et al 12 identified 3 of 11 patients in their review of DM and autoimmune thyroiditis who had thyroidectomy for nodular goitres before a diagnosis of DM was made. One patient in this retrospective review had non-Hodgkin's lymphoma but it is unclear what nodal sites or organs were involved.…”

Section: Discussionmentioning

confidence: 99%

Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature

et al. 2016

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A 55-year-old woman presented with a 3-week history of weakness. On examination, she had a heliotrope rash, V-neck and shawl signs. There was symmetric proximal muscle weakness, and 2/5 strength in upper and lower extremities. Laboratory values showed CK 5836, CRP 14.9, erythrocyte sedimentation rate 49, lactate dehydrogenase 633, negative antinuclear antibodies and anti-Jo1 antibodies. Muscle biopsy and immunohistochemistry findings were consistent with dermatomyositis. Treatment with high-dose steroids, cyclophosphamide and intravenous immunoglobulin (IVIG) was started, without improvement of symptoms. She was found to have cold agglutinins with a cold screen titre of 1:256,256. Work up for malignancy ensued. Positron emission tomography-computed tomography (PET-CT) showed increased uptake in the thyroid. Fine-needle thyroid biopsy with flow cytometry studies revealed atypical lymphocytes consistent with diffuse large B-cell lymphoma. The patient underwent R-CHOP therapy, with remarkable improvement of her symptoms. Dermatomyositis associated with primary thyroid lymphoma has not been previously reported. This case reinforces the importance of cancer screening in dermatomyositis patients.

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Dermatomyositis related to autoimmune thyroiditis

Cited by 9 publications

References 48 publications

Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

Drug-induced dermatomyositis after lacosamide: A case report

Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature

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