Dermatomyositis in patients with autoimmune blistering diseases

Patsatsi, Aikaterini; Pearson, David R.; Werth, Victoria P.

doi:10.1016/j.ijwd.2019.05.009

Cited by 5 publications

(10 citation statements)

References 35 publications

(45 reference statements)

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“…DM with blister has been reported in different terms in the literature, including DM with vesicle formation, vesiculobullous DM, and bullous DM ( 3 ). Apart from this, as reported in this study, there were a total of 14 cases reported so far in the literature that DM patients with blisters turned out to be AIBD eventually ( Table 1 ) ( 4 – 16 ).…”

Section: Discussionsupporting

confidence: 55%

Case Report: Concurrence of Dermatomyositis and Autoimmune Blistering Diseases: Two Case Reports and a Literature Review

et al. 2022

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Dermatomyositis (DM) is an idiopathic inflammatory myopathy primarily involving skin and muscles. Clinically amyopathic dermatomyositis (CADM), a subset of DM, presents with characteristic cutaneous manifestations without clinical evidence of myositis. Although rare, vesiculobullous eruptions could develop in DM patients. Such “bullous DM” is commonly considered a sign of internal malignancy. However, some cases with similar presentations were diagnosed as autoimmune blistering disease eventually. Herein, we reported two cases of CADM with autoimmune blisters formed. Case 1 presented with vesicles and was diagnosed with CADM initially. However, this patient developed blisters again years later and was diagnosed with “pemphigus foliaceous” (PF) accordingly. Case 2, with a history of nasopharyngeal carcinoma and CADM, developed bullous pemphigoid several days after using a heat patch on her abdomen. The association between disease occurrence and local skin damage might provide more evidence to support the “epitope spreading” hypothesis. Moreover, we reviewed related literature and discussed the differences between the two disease entities in clinical presentations, pathogenesis, therapy, and the risk of complications.

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Section: Discussionsupporting

confidence: 55%

Case Report: Concurrence of Dermatomyositis and Autoimmune Blistering Diseases: Two Case Reports and a Literature Review

et al. 2022

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“…A particular aspects of skin involvement in dermatomyositis is the synchronous rash with muscle involvement as seen in this case (1,2,3,4). The causes of dermatomyositis are autoimmune or cancer-related but sometimes as in mentioned case they remain as "idiopathic" (1,2,3,4). In this particular situation we avoid the use of an osteoanabolic drug as teriparatide for complicate glucocorticoid osteoporosis since an active neoplasia was not entirely excluded (7,8).…”

Section: Discussionmentioning

confidence: 98%

“…Some skin conditions require high doses of glucocorticoids as dermatomyositis (1,2). This a coetaneous and muscle inflammatory disease of various causes with heterogeneous clinical and histological aspects (3,4).…”

Section: Introductionmentioning

confidence: 99%

From dermatomyositis to osteoporosis

Şandru¹,

Valea²,

Albu³

et al. 2019

Ro J Med Pract.

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Our aim is to describe a case of a menopausal woman who started with dermatomyositis and then became a patient at endocrinology because of complicated glucocorticoid osteoporosis. This is a 63-year old female who suddenly started to accuse intense muscle pain associated with redness of the skin. She was confirmed with dermatomyositis and offered high doses of oral metilprednisolone. The thyroid ultrasound showed micronodular background and a small nodule of 0.7 cm without clinical relevance with an increase of antibodies thyroperoxidase antibody and normal thyroid function. Bone turnover markers were within normal in addition to decrease of serum 25-hydroxyvitamin D of 20 ng/ml. DXA (Dual-Energy X-Ray Absorptiometry) showed ostepenia based on a minimum T-score of-2.4 SD. The patient was offered high doses of cholecalciferol 2,000 UI per day and 500 mg of calcium daily in addition to weekly alendronate due to the high risk of fracture because of the glucocorticoid doses. 6 months later she suffered and accidental fall and a hip fracture was confirmed and required surgery. Further on the therapy was switched to zolendronic acid one injection per year. The dermatological and muscle progressively improved thus the doses of corticoids were reduced. As particular observation the presence of autoimmune thyroid condition may increase the risk of a second autoimmune disease like dermatomyositis, also the specific antibodies panel was negative. A multidisciplinary team needs to be involved in associated therapy for dermatomyositis and complications of glucocorticoids use.

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Rheumatic diseases associated with autoimmune bullous dermatosesAutoimmune bullous dermatoses (AIBDs) are a group of cutaneous disorders resulting from the deposition of autoreactive antibodies against various intraepithelial and subepidermal components. 1

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mentioning

confidence: 99%

“…2 Despite the fact that an association between AIBDs and several rheumatic diseases has been raised in the literature with the potentially shared immune pathomechanism and inflammatory pathway, it may be underestimated due to the rarity of these diseases. S1 [1][2][3] ). The rheumatic diseases associated with AIBDs were summarized in Table 1.…”

mentioning

confidence: 99%