Dermatomyofibroma

Campagnolo, Orley Alvaro; Morais, Carlos Floriano de; Ughini, Marina Ochoa; Aoki, Camile Mayumi; Menegazzo, Marília

doi:10.1590/abd1806-4841.20175189

Cited by 9 publications

(8 citation statements)

References 10 publications

(28 reference statements)

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“…2,4 Dermatomyofibromas are spindle cell tumors with a higher prevalence in young women located mostly in the shoulder and axilla regions. 21 It has been reported in children and predominantly affects male children. 22 Histologically the lesion comprises fascicles of spindle cells in the dermis, which are arranged parallel to the epidermis.…”

Section: Discussionmentioning

confidence: 99%

Plaque-like Myofibroblastic Tumor: 2 Cases of This Unusual Dermal Tumor Which Occurs in Infancy and Early Childhood

et al. 2017

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Plaque-like myofibroblastic tumor (PLMT) is a rare dermal spindle cell tumor which occurs in infancy or childhood within the first 4 years of life. The tumor is often pruritic and mostly presents on the lower back. We describe 2 cases with characteristic clinical and histological features of this entity, thus adding to the 10 cases which have so far been reported. Histologically, the lesion resembles a dermatofibroma. However, diffuse and uniform immunohistochemical staining with smooth muscle actin favors a myofibroblastic lineage. PLMT should be considered in the differential diagnosis of a dermal spindle cell tumor in the pediatric age-group.

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Section: Discussionmentioning

confidence: 99%

Plaque-like Myofibroblastic Tumor: 2 Cases of This Unusual Dermal Tumor Which Occurs in Infancy and Early Childhood

et al. 2017

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“…e. Dermatomyofibroma: Dermatomyofibroma is a rare benign cutaneous neoplasm of fibroblasts and myofibroblasts that favors the shoulders in young women (Campagnolo et al, 2017). Histologically, dermatomyofibroma appears as a well-circumscribed plaque composed of long fascicles of spindle-shaped cells running parallel to the skin surface through the reticular dermis (Viglizzo et al, 2008).…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

Cells to Surgery Quiz: January 2021

Schlessinger

Erickson

2021

Journal of Investigative Dermatology

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Which of the following is true regarding trial design and outcomes in the study by Delyon et al. (2020)? a. Partial response was defined as a reduction of the largest diameter of the tumor by 50% at 12 months or at surgery, if performed before 12 months.b. The majority of patients with surgery eventually had complete resection with free margins.c. The most common cutaneous adverse effect was alopecia.d. In matched tumor samples at a 6-month status after treatment with pazopanib, VEGF receptor (VEGFR) mRNA VEGFR-2 expression was significantly greater in responders than in nonresponders.e. Participants were excluded if they had previously received imatinib or if their DFSP exhibited fibrosarcomatous transformation. 3. What finding was DFSP associated with in the phase II clinical trial Delyon et al. (2020) a. Elevated plasma levels of soluble VEGFR-2 b. Presence of the COL1A1-PDGFB fusion gene c. Preserved p16 expression d. Overexpression of the transcripts associated with the EFGR pathway e. Reduced PDGF receptor signaling See the following pages for detailed answers

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“…Surgical excision is the treatment of choice with a low relapse rate even after incomplete excision (Gill, Arlette, Shiau, & Abi Daoud, ; Hügel, ; Mentzel & Kutzner, ). Most common single lesions are observed by multiple lesions have been described in rare cases (Campagnolo et al, ; Cano Martínez, Fernández‐Antón Martínez, Barchino Ortiz, Lecona Echevarría, & Campos Domínguez, ; Gomez‐Moyano, Vera‐Casaño, Martinez‐Garcia, Sanz‐Trelles, & Crespo‐Erchiga, ; Guillen & Requena, ; Hügel, ; Ma, Wieland, & Tollefson, ; Macedo, Mann, Zimmerman, Alves Mde, & Daxbacher, ; Mentzel & Kutzner, ; Romaní, Leal, Sáez, & Luelmo, ; Tardío et al, ; Viglizzo, Occella, Calonje, Nozza, & Rongioletti, ).…”

Section: Discussionmentioning

confidence: 99%

“…Less than 100 cases of dermatomyofibroma have been reported worldwide (Campagnolo, Morais, Ughini, Aoki, & Menegazzo, ; Mentzel & Kutzner, ). We present another case of this rare entity, which was successfully been treated by complete excision.…”

Section: Introductionmentioning

confidence: 99%